| Human | RETN | 56729 | resistin | levels of resistin are upregulated locally in the salivary glands of patients with primary Sjogren's syndrome (pSS); the levels of resistin correspond to the intensity of lymphocytic inflammation in patients with pSS |
| Human | TNFSF13B | 10673 | tumor necrosis factor (ligand) superfamily, member 13b | susceptibility for Ro/La-positive primary Sjogren's syndrome (pSS) is increased with the CTAT haplotype, but not with high s-BAFF levels; elevated s-BAFF in pSS are associated with the TTTT haplotype & may be a secondary phenomenon in Ro/La-positive pSS The known effect of B cells in periodontitis would be partly mediated by salivary BAFF in patients with primary Sjogren's syndrome BAFF gene polymorphism is neither involved in genetic predisposition to primary Sjogren's syndrome nor associated with a specific pattern of antibody production |
| Human | ADIPOQ | 9370 | adiponectin, C1Q and collagen domain containing | The high constitutive expression of adiponectin by salivary gland epithelial cells from patients with primary Sjogren's syndrome is likely attributable to aberrant activation of these cells |
| Human | TNFRSF1B | 7133 | tumor necrosis factor receptor superfamily, member 1B | study failed to demonstrate an association of TNFR2 T676G polymorphism with primary Sjogren's syndrome |
| Human | TNF | 7124 | tumor necrosis factor | TNF -308 single nucleotide polymorphism (TNF2) does not exhibit a significant influence on the disease course or immunological response in systemic lupus erythematosus and primary Sjogren's syndrome |
| Human | STAT4 | 6775 | signal transducer and activator of transcription 4 | Single nucleotide polymorphisms in the STAT4 gene are associated with primary Sjogren's syndrome |
| Human | SSB | 6741 | Sjogren syndrome antigen B (autoantigen La) | Increased Ro/SSA 60 and La/SSB mRNA expression in minor salivary glands in primary Sjogren's syndrome (pSS) suggest that these these 2 autoantigens, but not Ro/SSA 52, are involved in the tissue-specific autoimmune response in pSS |
| Human | TROVE2 | 6738 | TROVE domain family, member 2 | Increased Ro/SSA 60 and La/SSB mRNA expression in minor salivary glands in primary Sjogren's syndrome (pSS) suggest that these 2 autoantigens, but not Ro/SSA 52, are involved in tissue-specific autoimmune response in pSS |
| Human | SPTAN1 | 6709 | spectrin, alpha, non-erythrocytic 1 | The in vivo role of alpha-fodrin autoantigen in primary Sjogren's syndrome was analyzed |
| Human | NOS3 | 4846 | nitric oxide synthase 3 (endothelial cell) | study found primary Sjogren's syndrome patients carrying the high NO producer allele T of the eNOS +894 had a history of salivary gland swelling more frequently than non-carriers & age at disease onset was lower in T allele carriers compared with others |
| Human | NFKBIA | 4792 | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | promoter polymorphisms is associated with susceptibility to primary Sjogren's syndrome in Taiwan |
| Human | ITPR3 | 3710 | inositol 1,4,5-trisphosphate receptor, type 3 | Anti-IP(3)R1 antibodies were present in 48.6% of primary Sjogren's syndrome and in 3.0% of normal healthy subjects |
| Human | IRF5 | 3663 | interferon regulatory factor 5 | Primary Sjogren's syndrome and systemic lupus erythematosus share IRF gene polymorphisms as a common genetic susceptibility factor |
| Human | IL18 | 3606 | interleukin 18 (interferon-gamma-inducing factor) | In primary Sjogren's syndrome, infiltration of the salivary gland by macrophages and dendritic cells and expression of IL-18 and IL-12 play active roles in infiltrative injuries and have a correlation with predictors of lymphoma development |
| Human | IL2RA | 3559 | interleukin 2 receptor, alpha | Suggest that CD4+CD25+bright T cells were likely to play anti-inflammatory and immunosuppressive roles in the pathogenesis of primary Sjogren's syndrome |
| Human | CTLA4 | 1493 | cytotoxic T-lymphocyte-associated protein 4 | a lack of association between CTLA-4 CT60 or +49A/G polymorphisms and primary Sjogren syndrome |
| Human | CHRM3 | 1131 | cholinergic receptor, muscarinic 3 | demonstration of the antigenicity of a novel peptide fragment of the human muscarinic acetylcholine receptor 3 in primary Sjogren's syndrome |
| Human | BAK1 | 578 | BCL2-antagonist/killer 1 | Bak protein and its gene polymorphism may participate in the pathology and susceptibility of primary Sjogren's syndrome |
| Human | AGER | 177 | advanced glycosylation end product-specific receptor | This preliminary study supports the hypothesis that the RAGE system might participate in the disease pathway of primary Sjogren's syndrome (SS), and that sRAGE may be a potential biomarker to aid in the diagnosis of primary SS |
