| Human | RETN | 56729 | resistin | levels of resistin are upregulated locally in the salivary glands of patients with primary Sjogren's syndrome (pSS); the levels of resistin correspond to the intensity of lymphocytic inflammation in patients with pSS |
| Human | TNFSF13B | 10673 | tumor necrosis factor (ligand) superfamily, member 13b | The known effect of B cells in periodontitis would be partly mediated by salivary BAFF in patients with primary Sjogren's syndrome susceptibility for Ro/La-positive primary Sjogren's syndrome (pSS) is increased with the CTAT haplotype, but not with high s-BAFF levels; elevated s-BAFF in pSS are associated with the TTTT haplotype & may be a secondary phenomenon in Ro/La-positive pSS BAFF gene polymorphism is neither involved in genetic predisposition to primary Sjogren's syndrome nor associated with a specific pattern of antibody production |
| Human | ADIPOQ | 9370 | adiponectin, C1Q and collagen domain containing | The high constitutive expression of adiponectin by salivary gland epithelial cells from patients with primary Sjogren's syndrome is likely attributable to aberrant activation of these cells |
| Human | TNFRSF1B | 7133 | tumor necrosis factor receptor superfamily, member 1B | study failed to demonstrate an association of TNFR2 T676G polymorphism with primary Sjogren's syndrome |
| Human | TNF | 7124 | tumor necrosis factor | TNF -308 single nucleotide polymorphism (TNF2) does not exhibit a significant influence on the disease course or immunological response in systemic lupus erythematosus and primary Sjogren's syndrome |
| Human | STAT4 | 6775 | signal transducer and activator of transcription 4 | Single nucleotide polymorphisms in the STAT4 gene are associated with primary Sjogren's syndrome |
| Human | SSB | 6741 | Sjogren syndrome antigen B (autoantigen La) | Increased Ro/SSA 60 and La/SSB mRNA expression in minor salivary glands in primary Sjogren's syndrome (pSS) suggest that these these 2 autoantigens, but not Ro/SSA 52, are involved in the tissue-specific autoimmune response in pSS |
| Human | TROVE2 | 6738 | TROVE domain family, member 2 | Increased Ro/SSA 60 and La/SSB mRNA expression in minor salivary glands in primary Sjogren's syndrome (pSS) suggest that these 2 autoantigens, but not Ro/SSA 52, are involved in tissue-specific autoimmune response in pSS |
| Human | SPTAN1 | 6709 | spectrin, alpha, non-erythrocytic 1 | The in vivo role of alpha-fodrin autoantigen in primary Sjogren's syndrome was analyzed |
| Human | NOS3 | 4846 | nitric oxide synthase 3 (endothelial cell) | study found primary Sjogren's syndrome patients carrying the high NO producer allele T of the eNOS +894 had a history of salivary gland swelling more frequently than non-carriers & age at disease onset was lower in T allele carriers compared with others |
| Human | NFKBIA | 4792 | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | promoter polymorphisms is associated with susceptibility to primary Sjogren's syndrome in Taiwan |
| Human | ITPR3 | 3710 | inositol 1,4,5-trisphosphate receptor, type 3 | Anti-IP(3)R1 antibodies were present in 48.6% of primary Sjogren's syndrome and in 3.0% of normal healthy subjects |
| Human | IRF5 | 3663 | interferon regulatory factor 5 | Primary Sjogren's syndrome and systemic lupus erythematosus share IRF gene polymorphisms as a common genetic susceptibility factor |
| Human | IL18 | 3606 | interleukin 18 (interferon-gamma-inducing factor) | In primary Sjogren's syndrome, infiltration of the salivary gland by macrophages and dendritic cells and expression of IL-18 and IL-12 play active roles in infiltrative injuries and have a correlation with predictors of lymphoma development |
| Human | IL2RA | 3559 | interleukin 2 receptor, alpha | Suggest that CD4+CD25+bright T cells were likely to play anti-inflammatory and immunosuppressive roles in the pathogenesis of primary Sjogren's syndrome |
| Human | CTLA4 | 1493 | cytotoxic T-lymphocyte-associated protein 4 | a lack of association between CTLA-4 CT60 or +49A/G polymorphisms and primary Sjogren syndrome |
| Human | CHRM3 | 1131 | cholinergic receptor, muscarinic 3 | demonstration of the antigenicity of a novel peptide fragment of the human muscarinic acetylcholine receptor 3 in primary Sjogren's syndrome |
| Human | BAK1 | 578 | BCL2-antagonist/killer 1 | Bak protein and its gene polymorphism may participate in the pathology and susceptibility of primary Sjogren's syndrome |
| Human | AGER | 177 | advanced glycosylation end product-specific receptor | This preliminary study supports the hypothesis that the RAGE system might participate in the disease pathway of primary Sjogren's syndrome (SS), and that sRAGE may be a potential biomarker to aid in the diagnosis of primary SS |
