Human | GBP5 | 115362 | guanylate binding protein 5 | 3 genes were upregulated in patients with chronic EBV infection: guanylate binding protein 1, tumor necrosis factor-induced protein 6, and guanylate binding protein 5; they may be associated with the inflammatory reaction or with cell proliferation |
Human | TLR7 | 51284 | toll-like receptor 7 | The c.1-120G TLR7 allele offers protection from the development of inflammation and fibrosis in male patients with chronic HCV-infection This study reports the association of TLR7 variants with chronic HCV-infection and with the response to interferon-alpha therapy in patients with chronic HCV-infection |
Human | MASP2 | 10747 | mannan-binding lectin serine peptidase 2 | Concentrations and genotypes of MASP-2 and mannan-binding lectin in 109 cystic fibrosis patients were correlated to lung function and chronic infections |
Human | CXCR4 | 7852 | chemokine (C-X-C motif) receptor 4 | Chronic human papillomavirus (HPV) infection |
Human | TP53 | 7157 | tumor protein p53 | p53 single-nucleotide polymorphism is associated with the early development of hepatocellular carcinoma in Korean patients with chronic HBV infection |
Human | TNF | 7124 | tumor necrosis factor | in patients with chronic hepatatitis B infection, the TNF-alpha -863 A allele was significantly increased in the hepatocellular carcinoma group compared to healthy controls |
Human | PDCD1 | 5133 | programmed cell death 1 | Study demonstrates that the inhibitory molecule PD-1 is significantly upregulated on total and HCV-specific CD8(+) cytotoxic T cells in the peripheral blood and livers of patients with chronic infection |
Human | MX1 | 4599 | myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) | SNP of the MxA gene is one of the important host factors that independently influences the response to IFN in patients with chronic HCV infection, especially those with a low viral load |
Human | MTHFR | 4524 | methylenetetrahydrofolate reductase (NAD(P)H) | The methylenetetrahydrofolate reductase 677 T allele seems to protect against chronic HBV infection in young African adults |
Human | MT1A | 4489 | metallothionein 1A | MT-II mRNA expression may be involved in cell proliferation in the livers of patients with chronic HCV infection |
Human | MDM2 | 4193 | MDM2 oncogene, E3 ubiquitin protein ligase | MDM2 single-nucleotide polymorphism is associated with the early development of hepatocellular carcinoma in Korean patients with chronic HBV infection |
Human | LEP | 3952 | leptin | HCV infection interferes with fat and lipid metabolism in patients with chronic HCV infection and leptin may play a role in hepatosteatosis |
Human | IL17A | 3605 | interleukin 17A | Il-17 producing T cells are important in mucosal host defense, in the setting of retained antigenic stimulation, such as in asthma, chronic infection, and cystic fibrosis, or in the setting of autoimmunity, these cells can mediate immunopathology [review] |
Human | IL10 | 3586 | interleukin 10 | Increased IL10 production mediated by IL10-ht2 suggests that up-regulated IL10 accelerates progression of chronic HBV infection, especially to HCC development HCV-specific IL-10 Tr1 responses may play a dual role in HCV infection, dampening effector T-cells to promote viral persistence in acute infection but also protecting against progressive fibrosis in chronic infection IL-10 gene promoter polymorphisms significantly influence the mode and sequel of HBeAg seroconversion in patients with chronic HBV infection |
Human | IL4 | 3565 | interleukin 4 | Blocking of IL-4-induced activation of epithelial Stat6 by Helicobacter pylori in vitro may represent an evolutionarily conserved strategy to disrupt a Th2 response and evade the host immune system, allowing for successful chronic infection |
Human | IL1B | 3553 | interleukin 1, beta | IL-1beta-31 genotype T/T or the IL-1beta-511/-31 haplotype C-T is associated with the presence of HCC in Japanese patients with chronic HCV infection |
Human | HLA-DRB1 | 3123 | | HLA-DRB1*03 and HLA-DRB1*07 are related to susceptibility to chronic HBV infection, and DRB1*15 is negatively related to persistence to chronic HBV infection among people in northwestern China |
Human | HLA-DQB1 | 3119 | | These results indicate that different subtypes of HLA-DQA1 and DQB1 are associated with development of chronic HBV infection and LC, respectively, in Han Chinese population |
Human | FCAR | 2204 | Fc fragment of IgA, receptor for | FCAR promoter SNPs may be related to chronic HCV infection and disease progression in Japanese chronic hepatitis C |
Human | CTLA4 | 1493 | cytotoxic T-lymphocyte-associated protein 4 | The association of the CTLA4 -318C>T variation with chronic HBV infection and cryptogenic cirrhosis is described but find no association of the +49G>A variation with autoimmune liver disease |
Human | CCR5 | 1234 | chemokine (C-C motif) receptor 5 (gene/pseudogene) | article shows an association between chronic Mycoplasma pneumoniae infection and physician-diagnosed asthma and between the defective chemokine receptor CCR5 variant CCR5Delta32 and chronic Mycoplasma pneumoniae infection |
Human | CFTR | 1080 | cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) | In chronic P.aeruginosa lung infection, the transcription of four NF-kappaB-regulated cytokine genes is maximal in the presence of WT CFTR: the interleukin-8 (IL-8), IL-6, CXCL1, and intracellular adhesion molecule 1 (ICAM-1) genes |
Human | CD27 | 939 | CD27 molecule | CD27(-) effector CD8(+) T cells might be required for adequate control of chronic viral infection and prevention of disease development |
Human | CD2 | 914 | CD2 molecule | results showed that the expression of CD2 significantly increased with the severity of chronic HBV infection, which suggested that CD2 might contribute to the hepatocyte damage in chronic HBV infection |
Human | C5 | 727 | complement component 5 | There is no evidence that these C5 single nucleotide polymorphisms are genetic risk factors for the development of advanced fibrosis in chronic HCV infection or other chronic liver diseases |