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human : 15
mouse : 2
|Mouse||TFF1||7031||trefoil factor 1|
TFF1 knockout mice developed multiple gastric adenomas and carcinomas, suggesting that TFF1 is a gastric-specific tumor-suppressor gene.
|Mouse||IL6ST||3572||interleukin 6 signal transducer (gp130, oncostatin M receptor)|
Compared to gp130 (Y757F/Y757F) mice, reduced Stat3 activation in gp130 (Y757F/Y757F) Stat3(+/-) mice increased their lifespan, prevented splenomegaly, normalized exaggerated hepatic acute-phase response and lymphocyte trafficking, and suppressed the growth of spontaneously arising gastric adenomas in young mice.
|Human||PTPRVP||148713||protein tyrosine phosphatase, receptor type, V, pseudogene|
PATIENTS AND METHODS: Between November 1994 and June 1999, 118 gastric adenomas diagnosed on the basis of endoscopy and histological examinations of the forceps biopsy specimens obtained were treated by ESP or EMR at our department.
|Human||HIST4H4||121504||histone cluster 4, H4|
In immunohistochemistry, acetylated histone H4 was clearly detected in the nuclei of both non-neoplastic epithelial and stromal cells, whereas the levels of acetylated histone H4 were heterogeneous or reduced in 66% (38/57) of gastric carcinomas and 46% (6/13) of gastric adenomas.
Acetylated histone H4 is reduced in human gastric adenomas and carcinomas.
|Human||CKAP2||26586||cytoskeleton associated protein 2|
CKAP2 protein-expressing cells were also found in gastric adenomas.
|Human||EBAG9||9166||estrogen receptor binding site associated, antigen, 9|
In cases of normal gastric mucosae, gastric ulcers and gastric adenomas, RCAS1 was localized only in the perinuclear region of the mucosal epithelial cells (PN pattern), while, in most of gastric cancers (83.9%), it was detected diffusely in the cytoplasm and cell membranes of the tumor cells (DC pattern).
|Human||TFF1||7031||trefoil factor 1|
Tumours of patients with gastric cancer usually have reduced TFF1 levels and disruption of the TFF1 gene causes animals to develop gastric adenomas and carcinomas.
The stronger Shh expression in intestinal metaplasia and gastric adenoma indicates that hedgehog protein is involved at an early phase of gastric carcinogenesis
|Human||PTGS2||5743||prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)|
COX-2 may play a key role in the development and progression of gastric adenoma
|Human||FABP1||2168||fatty acid binding protein 1, liver|
METHODS: L-FABP expression was examined immunohistochemically in 667 gastric cancers, 60 gastric adenomas, and non-neoplastic epithelium contiguous with cancer tissue including normal foveolae, intestinal metaplasia, regenerative epithelium, and gastric glands.
|Human||ETS1||2113||v-ets avian erythroblastosis virus E26 oncogene homolog 1|
To elucidate the involvement of Ets-1 in human gastric carcinomas, we examined 11 cases of gastric adenoma and 110 cases of gastric carcinoma by immunohistochemistry and compared the degree of Ets-1 expression with the depth of carcinoma invasion.
Ets-1 was not expressed either in the normal gastric epithelium or in gastric adenomas.
|Human||E2F4||1874||E2F transcription factor 4, p107/p130-binding|
To characterize the genetic events during gastric carcinogenesis, we analyzed DNA from 56 gastric adenomas and 167 gastric carcinomas for MSI using five microsatellite markers and for frameshift mutations at coding nucleotide repeats of the type II transforming growth factor beta receptor, BAX, hMSH3, hMSH6, IGF II receptor, and E2F-4 genes.
In conclusion, the expressions of p53, p21/waf1, p27/kip1, and cyclin E were considered to be of great value for estimating the dysplastic progression of gastric adenomas.
Expression of cyclin E in human gastric adenomas and adenocarcinomas: correlation with proliferative activity and p53 status.
The expression of cyclin E in human gastric adenomas and adenocarcinomas was examined immunohistochemically to elucidate the role of cyclin E in stomach carcinogenesis.
|Human||CA9||768||carbonic anhydrase IX|
The variations observed in the CA IX levels support the concept that gastric adenomas and carcinomas are distinct entities and do not represent progressive steps of a single pathway
Over-expression of bcl-xL gene in human gastric adenomas and carcinomas.
|Human||BCL2A1||597||BCL2-related protein A1|
The expression of Bfl-1 gene, a novel Bcl-2 related gene, was determined by Northern blot analysis using a radiolabeled cDNA specific for Bfl-1 gene in 82 surgically resected tissue specimens of 28 gastric cancers, 15 colon cancers, nine breast cancers, eight bone and soft tissue sarcomas, five ovarian cancers, nine colon adenomas and eight gastric adenomas.
Bfl-1 gene was expressed in three (33%) out of nine adenomas of the colon, while it was not detected in all eight gastric adenomas, We also examined the RNA expression of Bfl-1 gene in 22 human cancer cell lines consisting of five stomach cancer, four squamous cell carcinoma, three lung cancer, three cervical cancer, two colon cancer, two brain cancer, two leukemia and one osteosarcoma cell lines.
|Human||APC||324||adenomatous polyposis coli|
somatic mutation of the APC gene plays an important role in the pathogenesis of gastric adenoma and dysplasia
Analyzed the phenotype, DNA ploidy patterns, and microsatellite regions linked to APC gene on chromosome 5q of low-grade gastric adenomas/dysplasias, Vienna Category 3, to investigate whether these lesions have the potential to become adenocarcinomas