Genes (37)
Species: human : 37 | |
Human | CRISP3 | 10321 | cysteine-rich secretory protein 3 | high levels of CRISP-3 in acinar cells dedifferentiating into small proliferating ductal cells in chronic pancreatitis suggests a role of this molecule in the pathophysiology of chronic pancreatitis | Human | ADIPOQ | 9370 | adiponectin, C1Q and collagen domain containing | Chronic pancreatitis in humans does not affect serum adiponectin levels | Human | TNFRSF10A | 8797 | tumor necrosis factor receptor superfamily, member 10a | likely to be involved in chronic pancreatitis; pancreatic stellate cells may directly contribute to acinar regression by inducing apoptosis of parenchymal cells in a TRAIL-dependent manner | Human | TNFRSF10B | 8795 | tumor necrosis factor receptor superfamily, member 10b | likely to be involved in chronic pancreatitis; pancreatic stellate cells may directly contribute to acinar regression by inducing apoptosis of parenchymal cells in a TRAIL-dependent manner | Human | TNFRSF10C | 8794 | tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain | likely to be involved in chronic pancreatitis; pancreatic stellate cells may directly contribute to acinar regression by inducing apoptosis of parenchymal cells in a TRAIL-dependent manner | Human | TNFRSF10D | 8793 | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | likely to be involved in chronic pancreatitis; pancreatic stellate cells may directly contribute to acinar regression by inducing apoptosis of parenchymal cells in a TRAIL-dependent manner | Human | TNFSF10 | 8743 | tumor necrosis factor (ligand) superfamily, member 10 | likely to be involved in chronic pancreatitis; pancreatic stellate cells may directly contribute to acinar regression by inducing apoptosis of parenchymal cells in a TRAIL-dependent manner | Human | TNF | 7124 | tumor necrosis factor | functional polymorphisms in the tumor necrosis factor-alpha gene promoter at positions -308 and -238 do not play a dominant role in alcoholic chronic pancreatitis high TNF secreting haplotypes, a2b3c1d1e3 and a2b5c2d4e3 were under-represented in chronic pancreatitis compared to healthy controls; a reduced capacity to produce TNF may be responsible for the induction of chronic pancreatitis | Human | TGFB1 | 7040 | transforming growth factor, beta 1 | TGF-beta 1 polymorphisms at positions -509, +869 (codon 10), and +915 (codon 25) do not play a dominant role in alcoholic chronic pancreatitis Functionally relevant genetic variants of the TGF-beta1 gene are not associated with nonalcoholic chronic pancreatitis | Human | SPP1 | 6696 | secreted phosphoprotein 1 | Increase in osteopontin is associated with pancreatic cancers and chronic pancreatitis Results provide the first evidence that osteopontin may play an important role in stone formation in chronic pancreatitis | Human | SPINK1 | 6690 | serine peptidase inhibitor, Kazal type 1 | Identification of SPINK1 mutations patients with adult alcoholic and idiopathic chronic pancreatitis suggests an important role for SPINK1 as a predisposing factor in adult chronic pancreatitis in most patients with SPINKI-associated chronic pancreatitis, this genetic variant acts as disease modifier or within a polygenic model with other yet unidentified genes or environmental co-factors SPINK1 gene mutation is associated with another base substitution in chronic pancreatitis patients Title:Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis|Association:Y|Conclusion: mutations/variants of SPINK1 gene with or without cystic fibrosis transmembrane conductance regulator gene may confer a high risk for recurrent pancreatitis Co-inheritance of a novel deletion of the entire SPINK1 gene with a CFTR missense mutation (L997F) is associated with chronic pancreatitis Variants of this alcohol-metabolizing enzyme appeared in the relation to alcoholic chronic pancreatitis SPINK1 mutations were associated with idiopathic and familial chronic pancreatitis, whereas the contribution was less evident in alcoholic chronic pancreatitis the SPINK1 N34S haplotype may have a role in chronic pancreatitis splicing mutation might represent a mechanism for SPINK1-associated chronic pancreatitis, but the N34S mutation is not associated with alternative splicing The results identify intracellular folding defects as a novel mechanism of SPINK1 deficiency associated with chronic pancreatitis | Human | SOD2 | 6648 | superoxide dismutase 2, mitochondrial | Polymorphisms of MnSOD and GSTP1 are not associated with chronic alcoholic pancreatitis | Human | CCL2 | 6347 | chemokine (C-C motif) ligand 2 | MCP-1 -2518 G allele does not significantly alter susceptibility to chronic pancreatitis MCP-1 polymorphism does not play a major role in the development of alcoholic chronic pancreatitis but may be associated with disease severity in Koreans | Human | RELA | 5970 | v-rel avian reticuloendotheliosis viral oncogene homolog A | RelA was decreased in PBMC from patients with chronic pancreatitis | Human | PTGS2 | 5743 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | COX-2 may be involved in inflammatory responses in chronic pancreatitis and in the progression of this chronic inflammatory disease | Human | PRSS3 | 5646 | protease, serine, 3 | The results classify E32del mesotrypsinogen as a frequent polymorphic variant, which is not associated with chronic alcoholic pancreatitis Absence of mesotrypsinogen gene (PRSS3) copy number variations in patients with chronic pancreatitis | Human | PRSS2 | 5645 | protease, serine, 2 (trypsin 2) | gene conversion between PRSS1 and PRSS2 trypsinogen genes can occur and cause genetically determined chronic pancreatitis A loss of function polymorphism (G191R) of anionic trypsinogen (PRSS2) confers protection against chronic pancreatitis G191R variant of PRSS2 mitigates intrapancreatic trypsin activity and thereby protects against chronic pancreatitis | Human | PRSS1 | 5644 | protease, serine, 1 (trypsin 1) | the mutation of PRSS1 gene, may not confer a high risk for recurrent pancreatitis Novel mutation and polymorphism of PRSS1 gene in the Chinese patients with hereditary pancreatitis and chronic pancreatitis Title:A signal peptide cleavage site mutation in the cationic trypsinogen gene is strongly associated with chronic pancreatitis.|Association:Y|Conclusion:Heterozygosity for the A16V mutation is strongly associated with CP. These results indicate that a significant percentage of patients with idiopathic CP may have a genetic basis for their disorder; therefore, genetic testing should be included in the diagnostic evaluation of these patients. gene conversion between PRSS1 and PRSS2 trypsinogen genes can occur and cause genetically determined chronic pancreatitis | Human | PNLIPRP2 | 5408 | pancreatic lipase-related protein 2 | Patients with chronic calcifying pancreatitis (CCP) had significantly lower levels of both pancreatic lipase and PLRP2 than the controls subjects | Human | MTHFR | 4524 | methylenetetrahydrofolate reductase (NAD(P)H) | The MTHFR C677T polymorphism could act as a possible risk factor for chronic pancreatitis and a possible protective factor in pancreatic adenocarcinoma | Human | MET | 4233 | met proto-oncogene | Overexpression of c-met occurs during the early stage of pancreatic carcinogenesis, and a single alteration of c-met expression is not sufficient for progression of chronic pancreatitis-affected epithelial cells to pancreatic cancer cells | Human | LEP | 3952 | leptin | Chronic pancreatitis in humans is associated with decreases in serum leptin and insulin concentrations | Human | KRAS | 3845 | Kirsten rat sarcoma viral oncogene homolog | Quantification of mutant KRAS2 in pancreatic juice differentiates pancreatic adenocarcinoma from chronic pancreatitis, and may be a useful early detection tool for pancreatic cancer Simultaneous measurement of K-ras and p16 mutations provides an additional tool in differential diagnosis of chronic pancreatitis and pancreatic adenocarcinoma | Human | CXCL10 | 3627 | chemokine (C-X-C motif) ligand 10 | The existence of CXCL10 and CXCR3 with other CXC/CC chemokine signature in chronic pancreatitis is suggestive of their vital role in the progression of chronic inflammation | Human | IL10 | 3586 | interleukin 10 | IL-10 gene promoter polymorphism at position -1082 does not play a dominant role in alcoholic chronic pancreatitis |
|