Human | MUC5B | 727897 | mucin 5B, oligomeric mucus/gel-forming | MUC5B mucin gene product secretion is significantly increased in chronic sinusitis compared with control subjects Thus gene is up-regulated in sinus mucosa of chronic rhinosinusitis and nasal polyposis |
Human | IL22RA1 | 58985 | interleukin 22 receptor, alpha 1 | study demonstrated IL-22R1 mRNA and protein expression on nasal epithelial cells; failure of medical and surgical therapy in chronic rhinosinusitis with nasal polyps is associated with significantly decreased expression of IL-22R1 |
Human | DNAI1 | 27019 | dynein, axonemal, intermediate chain 1 | |
Human | GPR44 | 11251 | prostaglandin D2 receptor 2 | These results suggest that expression of DP and CRTH2 is associated with the pathophysiology of chronic rhinosinusitis, and the expression of these receptors may be regulated by h-PGDS and PGD |
Human | TNFSF13B | 10673 | tumor necrosis factor (ligand) superfamily, member 13b | Overproduction of BAFF in nasal polyps may contribute to the pathogenesis of chronic rhinosinusitis with nasal polyps |
Human | VCAM1 | 7412 | vascular cell adhesion molecule 1 | This study aimed to assess which cytokines regulate the expression of the adhesion molecule E-cadherin and the multi-functional protein beta-catenin, which plays a key role in cadherin-mediated anchoring in eosinophilic chronic rhinosinusitis |
Human | TGFB1 | 7040 | transforming growth factor, beta 1 | TGF-beta may modulate the expression of chloride channel protein CLC-2 and CLC-3 in chronic rhinosinusitis without nasal polyps |
Human | TAPBP | 6892 | TAP binding protein (tapasin) | |
Human | TAP2 | 6891 | transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) | |
Human | TAP1 | 6890 | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | |
Human | MUC8 | 4590 | mucin 8 | MUC8 may play an important role in the pathogenesis of sinus hypersecretion in chronic rhinosinusitis |
Human | MMP9 | 4318 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | Alterations of MMP-2 and -9 expression may play a role in eosinophilic chronic rhinosinusitis, but the association with IL-5 and IL-13 remains unclear |
Human | MMP8 | 4317 | matrix metallopeptidase 8 (neutrophil collagenase) | significantly elevated sinus mucus levels associated with elevated IL-8 levels in chronic rhinosinusitis with nasal polyposis (CRSwNP); IL-8 and MMP-8 seemingly form an inductive cytokine-proteinase cascade in CRSwNP pathogenesis |
Human | MMP2 | 4313 | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | Alterations of MMP-2 and -9 expression may play a role in eosinophilic chronic rhinosinusitis, but the association with IL-5 and IL-13 remains unclear |
Human | MGP | 4256 | matrix Gla protein | |
Human | LTC4S | 4056 | leukotriene C4 synthase | C-to-A promoter polymorphism was associated with the increased presence of chronic hyperplastic eosinophilic sinusitis and the expression of cysteinyl leukotrienes |
Human | IL13 | 3596 | interleukin 13 | Alterations of MMP-2 and -9 expression may play a role in eosinophilic chronic rhinosinusitis, but the association with IL-5 and IL-13 remains unclear |
Human | IL12B | 3593 | interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) | possible role of IL-12 and tissue antioxidants in development and progression of chronic sinusitis |
Human | IL12A | 3592 | interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) | possible role of IL-12 and tissue antioxidants in development and progression of chronic sinusitis |
Human | IL8 | 3576 | interleukin 8 | significantly elevated levels of MMP-8 and IL-8 but not TNF-alpha were found in chronic rhinosinusitis with nasal polyposis (CRSwNP)patients; IL-8 and MMP-8 seemingly form an inductive cytokine-proteinase cascade in CRSwNP pathogenesis |
Human | IL5 | 3567 | interleukin 5 (colony-stimulating factor, eosinophil) | Alterations of MMP-2 and -9 expression may play a role in eosinophilic chronic rhinosinusitis, but the association with IL-5 and IL-13 remains unclear |
Human | IL4 | 3565 | interleukin 4 | Interleukin-4 may modulate the expression of chloride channel protein CLC-2 and CLC-3 in chronic rhinosinusitis without nasal polyps |
Human | CLCN3 | 1182 | chloride channel, voltage-sensitive 3 | CLC-3 is upregulated in ethmoid mucosa and may affect the development of chronic rhinosinusitis without nasal polyps |
Human | CLCN2 | 1181 | chloride channel, voltage-sensitive 2 | CLC-2 is upregulated in ethmoid mucosa and may affect the development of chronic rhinosinusitis without nasal polyps |
Human | CFTR | 1080 | cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) | The frequency of cystic fibrosis mutations has been reported to be higher in patients with chronic rhinosinusitis than in unaffected controls |