Genes (114)
Species: human : 113 mouse : 1 | |
Mouse | JUN | 3725 | jun proto-oncogene | Not only was sequence-specific AP-1 DNA binding constitutively active in malignant versus benign tumor cells, but so was transactivation of a unique AP-1-responsive chloramphenicol acetyltransferase reporter construct, pTiCTaK. | Human | GGT2 | 728441 | gamma-glutamyltransferase 2 | Six percent of all papillomas produced by two-stage carcinogenesis were GGT positive, whereas 14% of benign tumors produced by complete carcinogenesis exhibited GGT-positive areas. | Human | FLCN | 201163 | folliculin | Mutations lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg-Dube syndrome | Human | KISS1R | 84634 | KISS1 receptor | METHOD: The expression and their clinical significance of KiSS-1 and GPR54 were evaluated by RT-PCR in 37 patients with epithelial ovarian cancer, 15 patients with borderline epithelial ovarian tumors, 15 patients with epithelial benign tumors and 11 patients with normal ovarian tissues. | Human | WNT5B | 81029 | wingless-type MMTV integration site family, member 5B | Overexpression of the wnt5b gene in leiomyoma cells: implications for a role of the wnt signaling pathway in the uterine benign tumor. | Human | VTCN1 | 79679 | V-set domain containing T cell activation inhibitor 1 | B7-H4 expression was low in normal ovaries and in benign tumors while half of early stage and two-thirds of late stage cancers over-expressed B7-H4 | Human | KLK15 | 55554 | kallikrein-related peptidase 15 | RESULTS: KLK15 expression levels were significantly higher in cancerous tissues compared with benign tumors. | Human | XAF1 | 54739 | XIAP associated factor 1 | Although the XAF1 expression in circulation of those with CRC was also lower than in those with benign tumors, there was no statistical significance (P > 0.05). | Human | PDCD4 | 27250 | programmed cell death 4 (neoplastic transformation inhibitor) | These results extend to an in vivo model the observations that Pdcd4 inhibits both translation initiation and AP-1 activation while decreasing benign tumor development and malignant progression. | Human | GNL3 | 26354 | guanine nucleotide binding protein-like 3 (nucleolar) | All detected malignant tumor tissues, benign tumor tissues, and benign hyperplastic tissues had high levels of nucleostemin expression. Eighteen kinds of malignant tumor tissues including gastric adenocarcinoma and liver cancer tissues, 3 kinds of benign tumor tissues, 3 kinds of benign hyperplastic tissues and normal tissues were employed to examine nucleostemin gene expression by RT-PCR, Slot blot, Northern blot and in situ hybridization. | Human | PSIP1 | 11168 | PC4 and SFRS1 interacting protein 1 | Using enzyme-linked immunoabsorbent assays for the soluble tumor necrosis factor (TNF) receptors type I (p55) and type II (p75) and IL-2 receptor we determined their levels in the plasma of 378 patients with various solid carcinomas, 56 patients with benign tumors, and 241 healthy controls. | Human | COPS5 | 10987 | COP9 signalosome subunit 5 | RESULTS: Jab1 overexpression was detected in 68.1% (32 of 47) of malignant tumors and 33.3% (11 of 33) of benign tumors. | Human | IGF2BP1 | 10642 | insulin-like growth factor 2 mRNA binding protein 1 | CRD-BP expression has also been detected in benign tumors such as breast fibroadenomas, meningiomas and other benign mesenchymal tumors, implying a role for this gene in abnormal cell proliferation. | Human | MVP | 9961 | major vault protein | RESULTS: In normal ovary, benign tumor and ovarian cancer, the positive expression of MDR1 was 0.0%, 0.0% and 29.3%, the positive of MRP was 16.7%, 12.0% and 53.7%, the positive of LRP was 25.0%, 52.0% and 87.8%, the positive of GST-pi was 8.3%, 12.0% and 51.2% respectively. | Human | SART3 | 9733 | squamous cell carcinoma antigen recognized by T cells 3 | The SART3 antigen was detected in all of the oral cancer cell lines tested, 24 of 31 (77%) oral cancer tissue samples, 0 of 3 oral benign tumors and 0 of 3 normal oral tissues. | Human | LRAT | 9227 | lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) | Of the 10 tumors that stained 3+ for LRAT in the study, 9 were either benign tumors or tumors with low malignant potential. | Human | EBAG9 | 9166 | estrogen receptor binding site associated, antigen, 9 | RCAS1 was present in all neoplastic, placental and trophoblast tissue samples and its level in malignant samples was statistically significantly higher than in benign neoplasms. | Human | P2RX6 | 9127 | purinergic receptor P2X, ligand-gated ion channel, 6 | Among the 47 sarcomas examined by reverse transcription polymerase chain reaction, 12 had lost expression of this gene and 22 revealed altered splicing patterns; among the nine benign tumours, four showed no expression of P2XM and three revealed aberrant splicing patterns involving transmembrane domains M1 and/or M2. We investigated expression of a human p53-inducible gene, P2XM, a member of the P2X-receptor family of ATP-gated ion channels, in 56 human primary soft-tissue tumours including 47 sarcomas and nine benign tumors. | Human | MBD2 | 8932 | methyl-CpG binding domain protein 2 | In pathological tissues samples MBD2 mRNA levels are significantly higher (P=0.001) in benign tumors compared with normal breast tissues, whereas MeCP2 expression is not modified in these specimens. The amounts of MBD2 and MeCP2 transcripts vary greatly between samples in cancer cells compared to normal breast tissues or benign tumors, and in invasive ductal carcinomas the amount of MBD2 mRNA is significantly (P=0.03) associated with the tumor size. | Human | TNFRSF10D | 8793 | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | Reverse transcriptase polymerase chain reaction (RT-PCR) was applied to assay mRNA expression of TRAIl(the TNF related apoptosis inducing ligand) receptors (DR5, DcR1, and DcR2) in 3 cases of normal ovarian tissues, 6 cases of ovarian benign tumors, and 16 cases of ovarian cancers. Positive expression of the DcR2 was only found in normal ovaries and benign tumors. [Expression of different receptors of the apoptosis inducing gene TRAIL in human ovarian tumors] Reverse transcriptase polymerase chain reaction (RT-PCR) was applied to assay mRNA expression of TRAIl(the TNF related apoptosis inducing ligand) receptors (DR5, DcR1, and DcR2) in 3 cases of normal ovarian tissues, 6 cases of ovarian benign tumors, and 16 cases of ovarian cancers. Positive expression of the DcR2 was only found in normal ovaries and benign tumors. | Human | ADAM9 | 8754 | ADAM metallopeptidase domain 9 | In vivo, the steady-state of both ADAM9 and ADAM12 mRNA levels was nearly undetectable in both normal livers and benign tumors and increased in hepatocellular carcinomas (up to 3- and 6-fold, respectively) and liver metastases from colonic carcinomas (up to 40- and 60-fold, respectively). | Human | TP63 | 8626 | tumor protein p63 | In general, benign mixed tumors showed a basal cell compartment immunoreactive to p63, with a gradual decrease of its expression during myoepithelial transformation. Normal mammary glands, mammary hyperplasias, and benign tumors showed 100% immunoreactivity, with p63 expression restricted to myoepithelial cell nuclei. | Human | HMGA2 | 8091 | high mobility group AT-hook 2 | Click here to display 18 evidence detail records. | Human | ADAM12 | 8038 | ADAM metallopeptidase domain 12 | In vivo, the steady-state of both ADAM9 and ADAM12 mRNA levels was nearly undetectable in both normal livers and benign tumors and increased in hepatocellular carcinomas (up to 3- and 6-fold, respectively) and liver metastases from colonic carcinomas (up to 40- and 60-fold, respectively). | Human | NCOA4 | 8031 | nuclear receptor coactivator 4 | The relative frequency of RET/PTC1 and RET/PTC3 in rearranged benign tumors showed no major difference. |
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