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Genes (15)
Species: human : 15 | |
Human | TNF | 7124 | tumor necrosis factor | Taken together, these results show an association between severity of depressive symptoms and expression of pro-inflammatory cytokines in patients with HCV | Human | SLC6A4 | 6532 | solute carrier family 6 (neurotransmitter transporter), member 4 | A serotonin-related gene polymorphism--5HTTLPR--was associated with adverse cardiac events post CABG, in combination with depressive symptoms study tested the hypothesis that the 5-HTT gene-linked polymorphic-region (5-HTTLPR) polymorphism is associated with SSRI antidepressant response by evaluating depressive symptoms for Chinese patients diagnosed with major depression The relationship between exposure to abuse and elevated depressive symptoms was more pronounced in the 5-HTTLPR s/s allele group than in the s/l group and the l/l group, but this was detected only after excluding women with recent use of psychotropics | Human | NR3C2 | 4306 | nuclear receptor subfamily 3, group C, member 2 | no differences in cognitive functioning were observed dependent on the polymorphisms in the MR and GR genes in older adults; I180V variant in the MR gene influenced the prevalence of depressive symptoms, independently from cognitive functioning | Human | MAOA | 4128 | monoamine oxidase A | Heightened depressive symptoms were found only among extensively maltreated youth with low MAOA activity Individuals with less active MAOA-uVNTR alleles may be at increased risk for depressive symptoms and poor sleep | Human | IL1B | 3553 | interleukin 1, beta | No significant difference was found in genetic polymorphism for interleukin 1 beta between major depressive disorder patients and controls; however, patients homozygous for 511T allele had a trend of less severe depressive symptoms than 511C carriers | Human | IFNAR1 | 3454 | interferon (alpha, beta and omega) receptor 1 | The promoter GT repeat dinucleotide microsatellite polymorphism of the IFNAR1 gene may represent a risk factor for the development of depressive symptoms during IFN-alpha therapy for hepatitis C and other conditions | Human | HTR2A | 3356 | 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled | Psychosis onset in Alzheimer disease is strongly associated with severity of depressive symptoms, an association that may be modified by HTR2A polymorphism | Human | GRIN1 | 2902 | glutamate receptor, ionotropic, N-methyl D-aspartate 1 | Significant associations in single-marker and haplotype-based analyses pf variants and schiophrenia with depressive symptoms | Human | DRD2 | 1813 | dopamine receptor D2 | DRD2 polymorphism moderates the effect of stressful life events on depressive symptoms and those who carry A2/A2 DRD2 genotypes may be more vulnerable than others | Human | DAO | 1610 | D-amino-acid oxidase | These data suggest a potential role for DAO in susceptibility to depressive symptoms in schizophrenia, but a more general role for DAO in affective disorders cannot be excluded | Human | CRHR1 | 1394 | corticotropin releasing hormone receptor 1 | 2 independent samples to test for associations of corticotropin-releasing hormone receptor gene (CRHR1) polymorphisms with adult depressive symptoms following early child abuse To examine whether the effects of child abuse on adult depressive symptoms are moderated by genetic polymorphisms within the corticotropin-releasing hormone type 1 receptor (CRHR1) gene | Human | BDNF | 627 | brain-derived neurotrophic factor | brain derived neurotrophic factor Met allele(s) moderated the effect of early adversity on depressive symptoms (two-way interaction) in the mothers with adult-onset depression the Val/Met genotype was associated with more depressive symptoms, and rumination again mediated the relationship between genotype and depression The BDNF may be a susceptibility gene for MDD and schizophrenia-in particular, in a subgroup of patients with schizophrenia with a lifetime history of depressive symptoms | Human | AR | 367 | androgen receptor | findings show androgen receptor (AR) CAG repeat length (RL) might modify the association between endogenous total and bioavailable testosterone and depressive symptoms in younger black men | Human | APOE | 348 | apolipoprotein E | The APOE epsilon4 status modifies the association between depressive symptoms and dementia in elderly men | Human | ADCY7 | 113 | adenylate cyclase 7 | Brain type VII adenylyl cyclase isoform plays a sex-specific role in the manifestation of a heritable form of depressive symptoms in genetically modified mice |
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