Genes (35)
Species: human : 35 | |
Human | ANKK1 | 255239 | ankyrin repeat and kinase domain containing 1 | study supports other family-based association tests that have reported no association between the DRD2 TaqIA polymorphism and alcohol abuse and dependence | Human | APOA5 | 116519 | apolipoprotein A-V | Multiple causes, including insulin-dependent diabetes mellitus, contraceptive steroids, alcohol abuse, and glycogen storage disease I | Human | KCNMB4 | 27345 | potassium large conductance calcium-activated channel, subfamily M, beta member 4 | The beta4 subunit controls ethanol tolerance at the molecular, cellular, and behavioral levels, and could determine individual differences in alcohol abuse and alcoholism, as well as represent a therapeutic target for alcoholism | Human | TPH1 | 7166 | tryptophan hydroxylase 1 | Title:A Functional Polymorphism in the Promoter Region of the Tryptophan Hydroxylase Gene Is Associated With Alcohol Dependence in One Aboriginal Group in Taiwan|Association:Y|Conclusion:Polymorphisms in the promoter region may influence the function of the TPH1 gene and further influence the proclivity of alcohol dependence in one ethnic group in Taiwan. The associations between TPH1 genotypes and alcoholism may deserve further investigation. | Human | TNF | 7124 | tumor necrosis factor | Title:Relation of tumor necrosis factor (TNF) gene polymorphisms with serum concentrations and in vitro production of TNF-alpha and interleukin-8 in heavy drinkers.|Association:Y|Conclusion:In comparison with findings for control subjects, heavy drinkers showed higher TNF-alpha production, higher IL-8 production, and higher serum IL-8 concentrations. Increased serum TNF-alpha concentrations were specifically found in heavy drinkers with the -857 (C-->T) substitution (CT heterozygotes), therefore indicating an interaction between alcohol consumption and that polymorphism on serum TNF-alpha concentrations. | Human | TF | 7018 | transferrin | analyses and comparison of the oligosaccharides present on the different isoforms of purified transferrin isolated from control and patients with severe alcohol abuse | Human | SLC6A4 | 6532 | solute carrier family 6 (neurotransmitter transporter), member 4 | Title:Role of the serotonin transporter gene and family function in adolescent alcohol consumption.|Association:Not Found|Conclusion:In sum, our results show that a functional polymorphism of the 5-HTT genotype, family relations, and interactions between these variables predict adolescent alcohol consumption in a randomized sample of adolescents. Title:Genetic influences on quantity of alcohol consumed by adolescents and young adults.|Association:Not Found|Conclusion:Genetic influence on drinking behavior was common in adolescents longitudinally assessed 1 year apart, but was less correlated between these adolescents and their assessment as young adults at a subsequent time point. Polymorphisms in genes of the dopaminergic system appear to influence variation in drinking behavior. Title:SEROTONIN TRANSPORTER PROMOTER POLYMORPHISM AND DIFFERENCES IN ALCOHOL CONSUMPTION BEHAVIOUR IN A COLLEGE STUDENT POPULATION|Association:Not Found|Conclusion:In this Caucasian sample, the 5-HTTLPR strongly influences alcohol consumption in late pubescence. Title:Candidate genes for alcohol dependence: a review ofgenetic evidence from human studies.|Association:Not Found|Conclusion:Review article Title:Serotonin transporter promoter polymorphism and monoamine oxidase type A VNTR allelic variants together influence alcohol binge drinking risk in young women.|Association:Not Found|Conclusion:These results support the hypothesis that binge drinking behavior in young adulthood may be influenced by neurobiological differences in serotonergic function conferred by functional polymorphisms in genes involved in serotonin processing. Title:[Alcohol dependence and polymorphisms of serotonin-related genes]|Association:Not Found|Conclusion:Genes involved in the transmission, reuptake and metabolism of serotonin constitute a set of candidate genes that could be involved in core aspects of alcoholism, such as the tendency to prefer immediate reward, despite negative consequences. | Human | SLC6A3 | 6531 | solute carrier family 6 (neurotransmitter transporter), member 3 | Title:Evidence for the importance of the human dopamine transporter gene for withdrawal symptomatology of alcoholics in a German population.|Association:Not Found|Conclusion:Our findings provide further evidence that the 3'UTR of the DAT1 gene affects vulnerability to severe alcohol withdrawal. Title:Genetic influences on quantity of alcohol consumed by adolescents and young adults.|Association:Not Found|Conclusion:Genetic influence on drinking behavior was common in adolescents longitudinally assessed 1 year apart, but was less correlated between these adolescents and their assessment as young adults at a subsequent time point. Polymorphisms in genes of the dopaminergic system appear to influence variation in drinking behavior. | Human | OPRM1 | 4988 | opioid receptor, mu 1 | Title:Increased attributable risk related to a functional mu-opioid receptor gene polymorphism in association with alcohol dependence in central Sweden.|Association:Y|Conclusion:In central Sweden, the functional variant 118G allele in exon 1 of OPRM1 is associated with an increased attributable risk for alcohol dependence. Title:A Polymorphism of the mu-Opioid Receptor Gene (OPRM1) and Sensitivity to the Effects of Alcohol in Humans|Association:Not Found|Conclusion:These findings may help to explain previous research suggesting that naltrexone is more effective among individuals with the G allele. A medication that reduces feelings of euphoria after alcohol consumption may be more successful among individuals with a genetic predisposition to greater feelings of euphoria after consuming alcohol. Title:A functional polymorphism of the mu-opioid receptor gene is associated with naltrexone response in alcohol-dependent patients.|Association:Y|Conclusion:These preliminary results are consistent with prior literature demonstrating that the opioid system is involved in the reinforcing properties of alcohol and that allelic variation at OPRM1 is associated with differential response to a &mgr;-receptor antagonist. If replicated, these results would help to identify alcohol-dependent individuals who may be most likely to respond to treatment with naltrexone. Title:A functional polymorphism within the mu-opioid receptor gene and risk for abuse of alcohol and other substances.|Association:Not Found|Conclusion:The contribution of the gene to risk for substance dependence is small, and is detected most easily in studies that use control samples that are screened for all forms of substance dependence. | Human | NPY | 4852 | neuropeptide Y | Title:NPY leu7pro and Alcohol Dependence in Finnish and Swedish Populations|Association:Not Found|Conclusion:Pro7 does not seem to be associated with a diagnosis of alcoholism in Caucasian populations. Title:A novel single nucleotide polymorphism of the neuropeptide Y (NPY) gene associated with alcohol dependence.|Association:Y|Conclusion:We report a novel polymorphism at position -602 in the 5' region of the NPY gene that is significantly associated with alcohol dependence. We also describe the haplotype frequencies and linkage dysequilibrium pattern of four variations in that region. Title:Distribution of the NPY 1128C allele frequency in different populations|Association:Not Found|Conclusion:The 1128C allele was observed in all populations of European descent and the Israeli population, with a mean frequency of about 4%. The allele frequency showed a geographical north to south gradient of decreasing frequency. The highest allele frequencies were found in Nordic countries. The NPY 1128C allele might originate in the north of Europe, and then spread to neighboring regions. Title:Candidate genes for alcohol dependence: a review ofgenetic evidence from human studies.|Association:Not Found|Conclusion:Review article | Human | NQO2 | 4835 | NAD(P)H dehydrogenase, quinone 2 | Title:Association analyses between polymorphisms of the phase II detoxification enzymes (GSTM1, NQO1, NQO2) and alcohol withdrawal symptoms.|Association:Y|Conclusion:Present data suggest that an insertion/deletion polymorphism in the promoter region of the NQO2 gene plays an important role in the pathogenesis of alcoholism and alcohol withdrawal symptoms. | Human | MAOA | 4128 | monoamine oxidase A | Title:Serotonin transporter promoter polymorphism and monoamine oxidase type A VNTR allelic variants together influence alcohol binge drinking risk in young women.|Association:Not Found|Conclusion:These results support the hypothesis that binge drinking behavior in young adulthood may be influenced by neurobiological differences in serotonergic function conferred by functional polymorphisms in genes involved in serotonin processing. | Human | IL8 | 3576 | interleukin 8 | Title:Relation of tumor necrosis factor (TNF) gene polymorphisms with serum concentrations and in vitro production of TNF-alpha and interleukin-8 in heavy drinkers.|Association:Y|Conclusion:In comparison with findings for control subjects, heavy drinkers showed higher TNF-alpha production, higher IL-8 production, and higher serum IL-8 concentrations. Increased serum TNF-alpha concentrations were specifically found in heavy drinkers with the -857 (C-->T) substitution (CT heterozygotes), therefore indicating an interaction between alcohol consumption and that polymorphism on serum TNF-alpha concentrations. | Human | HTR7 | 3363 | 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled | Title:[Alcohol dependence and polymorphisms of serotonin-related genes]|Association:Not Found|Conclusion:Genes involved in the transmission, reuptake and metabolism of serotonin constitute a set of candidate genes that could be involved in core aspects of alcoholism, such as the tendency to prefer immediate reward, despite negative consequences. | Human | HTR5A | 3361 | 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled | Title:[Alcohol dependence and polymorphisms of serotonin-related genes]|Association:Not Found|Conclusion:Genes involved in the transmission, reuptake and metabolism of serotonin constitute a set of candidate genes that could be involved in core aspects of alcoholism, such as the tendency to prefer immediate reward, despite negative consequences. | Human | HTR2C | 3358 | 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled | Title:[Alcohol dependence and polymorphisms of serotonin-related genes]|Association:Not Found|Conclusion:Genes involved in the transmission, reuptake and metabolism of serotonin constitute a set of candidate genes that could be involved in core aspects of alcoholism, such as the tendency to prefer immediate reward, despite negative consequences. Title:Candidate genes for alcohol dependence: a review ofgenetic evidence from human studies.|Association:Not Found|Conclusion:Review article | Human | HTR2A | 3356 | 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled | Title:[Alcohol dependence and polymorphisms of serotonin-related genes]|Association:Not Found|Conclusion:Genes involved in the transmission, reuptake and metabolism of serotonin constitute a set of candidate genes that could be involved in core aspects of alcoholism, such as the tendency to prefer immediate reward, despite negative consequences. Title:Candidate genes for alcohol dependence: a review ofgenetic evidence from human studies.|Association:Not Found|Conclusion:Review article | Human | HTR1B | 3351 | 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled | Title:Candidate genes for alcohol dependence: a review ofgenetic evidence from human studies.|Association:Not Found|Conclusion:Review article | Human | GSTM1 | 2944 | glutathione S-transferase mu 1 | Title:Association analyses between polymorphisms of the phase II detoxification enzymes (GSTM1, NQO1, NQO2) and alcohol withdrawal symptoms.|Association:Not Found|Conclusion:Present data suggest that an insertion/deletion polymorphism in the promoter region of the NQO2 gene plays an important role in the pathogenesis of alcoholism and alcohol withdrawal symptoms. | Human | GABRG2 | 2566 | gamma-aminobutyric acid (GABA) A receptor, gamma 2 | Title:Candidate genes for alcohol dependence: a review ofgenetic evidence from human studies.|Association:Not Found|Conclusion:Review article Title:Association of the gamma-aminobutyric acid A receptor gene cluster with alcohol dependence in Taiwanese Han.|Association:Not Found|Conclusion:These LD findings, together with the association results, suggest that the GABRA6 and GABRA1 genes account for alcohol susceptibility in Han and exert their genetic influences in a somewhat dominant and synergistic fashion. | Human | GABRB2 | 2561 | gamma-aminobutyric acid (GABA) A receptor, beta 2 | Title:Association of the gamma-aminobutyric acid A receptor gene cluster with alcohol dependence in Taiwanese Han.|Association:Not Found|Conclusion:These LD findings, together with the association results, suggest that the GABRA6 and GABRA1 genes account for alcohol susceptibility in Han and exert their genetic influences in a somewhat dominant and synergistic fashion. | Human | GABRA6 | 2559 | gamma-aminobutyric acid (GABA) A receptor, alpha 6 | Title:Association of the gamma-aminobutyric acid A receptor gene cluster with alcohol dependence in Taiwanese Han.|Association:Y|Conclusion:These LD findings, together with the association results, suggest that the GABRA6 and GABRA1 genes account for alcohol susceptibility in Han and exert their genetic influences in a somewhat dominant and synergistic fashion. Title:Candidate genes for alcohol dependence: a review ofgenetic evidence from human studies.|Association:Not Found|Conclusion:Review article | Human | GABRA1 | 2554 | gamma-aminobutyric acid (GABA) A receptor, alpha 1 | Title:Association of the gamma-aminobutyric acid A receptor gene cluster with alcohol dependence in Taiwanese Han.|Association:Y|Conclusion:These LD findings, together with the association results, suggest that the GABRA6 and GABRA1 genes account for alcohol susceptibility in Han and exert their genetic influences in a somewhat dominant and synergistic fashion. Title:Candidate genes for alcohol dependence: a review ofgenetic evidence from human studies.|Association:Not Found|Conclusion:Review article | Human | DRD4 | 1815 | dopamine receptor D4 | Title:The DRD4 VNTR polymorphism moderates craving after alcohol consumption|Association:Y|Conclusion:Results suggested that DRD4 L participants demonstrated significantly higher craving after consumption of alcohol as compared with the control beverage. Title:Olanzapine reduces craving for alcohol: a DRD4 VNTRpolymorphism by pharmacotherapy interaction.|Association:Not Found|Conclusion:The findings indicated that olanzapine reduces craving for alcohol at baseline for both DRD4 S and DRD4 L individuals, but only reduces craving after exposure to alcohol cues and after a priming dose of alcohol for DRD4 L individuals. Title:Genetic influences on quantity of alcohol consumed by adolescents and young adults.|Association:Not Found|Conclusion:Genetic influence on drinking behavior was common in adolescents longitudinally assessed 1 year apart, but was less correlated between these adolescents and their assessment as young adults at a subsequent time point. Polymorphisms in genes of the dopaminergic system appear to influence variation in drinking behavior. | Human | DRD3 | 1814 | dopamine receptor D3 | Title:Candidate genes for alcohol dependence: a review ofgenetic evidence from human studies.|Association:Not Found|Conclusion:Review article |
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