Genes (251)
Species: human : 244 mouse : 7 | |
Mouse | LHX2 | 9355 | LIM homeobox 2 | The disorder was transplantable and the Lhx2-expressing cells could also cause acute leukemia. | Mouse | CCL21 | 6366 | chemokine (C-C motif) ligand 21 | CONCLUSIONS: The chemokine CCL21 may be able to prevent Ara-C myelosuppression during acute leukemia induction chemotherapy, and thereby decrease morbidity and mortality of such therapy, and shorten hospital stays. | Mouse | PBX1 | 5087 | pre-B-cell leukemia homeobox 1 | These results demonstrate a causative role for p85E2A-Pbx1 in human acute leukemia and indicate that the oncogenic potential of Pbx1 is not limited to pre-B-cell malignancies. | Mouse | MPL | 4352 | myeloproliferative leukemia virus oncogene | The myeloproliferative leukemia virus (MPLV), a novel murine retroviral complex that does not transform fibroblasts, has been shown to cause an acute leukemia in adult mice accompanied by a progressive polycythemia. | Mouse | AFF1 | 4299 | AF4/FMR2 family, member 1 | Cloning and developmental expression of the murine homolog of the acute leukemia proto-oncogene AF4. | Mouse | CDX4 | 1046 | caudal type homeobox 4 | Together, these data indicate that Cdx4 regulates Hox gene expression in adult hematopoiesis and may serve as an upstream regulator of Hox gene expression in the induction of acute leukemia. | Mouse | CD80 | 941 | CD80 molecule | Gene transfer of GM-CSF, CD80 and CD154 cDNA enhances survival in a murine model of acute leukemia with persistence of a minimal residual disease. | Human | PPBPL1 | 728045 | | Plasma beta-thromboglobulin values in thrombocytopenic patients with acute leukemia. The plasma concentration of beta-thromboglobulin was serially measured in nine patients with septicemia, ten patients with pneumonia and five thrombo- and granulocytopenic patients with acute leukemia. Plasma beta-thromboglobulin (beta-TG) levels were measured in 14 healthy subjects and in 20 acute leukemia (AL) patients, newly diagnosed, with highly variable values for venous platelet counts. | Human | LOC644165 | 644165 | | In the Philadelphia positive bcr negative acute leukemias (Ph1+bcr- AL), the chromosomal breakpoints on chromosome 22 have been shown clustered within 10.8kb (bcr2) and 5kb (bcr3) fragments of the first intron of the BCR gene. Rearrangements in the BCR gene first intron, the so-called bcr2 and bcr3 regions, were detected in two other cases, one with an acute lymphoblastic leukemia (ALL) and one with mixed acute leukemia. | Human | FLJ42953 | 400892 | | In the Philadelphia positive bcr negative acute leukemias (Ph1+bcr- AL), the chromosomal breakpoints on chromosome 22 have been shown clustered within 10.8kb (bcr2) and 5kb (bcr3) fragments of the first intron of the BCR gene. Molecular cloning of a 5; segment of the genomic phl gene defines a new breakpoint cluster region (bcr2) in Philadelphia-positive acute leukemias. Rearrangements in the BCR gene first intron, the so-called bcr2 and bcr3 regions, were detected in two other cases, one with an acute lymphoblastic leukemia (ALL) and one with mixed acute leukemia. | Human | P2RY8 | 286530 | purinergic receptor P2Y, G-protein coupled, 8 | P2RY8 is expressed in leukemic cells and has an unexpected role in the pathogenesis of acute leukemia | Human | FRYL | 285527 | FRY-like | Thus, t(4;11)(p12;q23) with MLL and FRYL involvement represents a new recurring 11q23 translocation, to date seen only in therapy-related acute leukemias | Human | PIKFYVE | 200576 | phosphoinositide kinase, FYVE finger containing | The study of acute leukemias allow to conclude that: 1) it exists in peripheral blood a synthetic activity of ADN bound to the presence of leukemic or blastic cells; 2) this activity allows to appreciate the spontaneous variations of synthesis and the incidence of chemotherapy. | Human | ZNF384 | 171017 | zinc finger protein 384 | Click here to display 7 evidence detail records. | Human | FAM123B | 139285 | | there was not any evidence of WTX mutation in the 143 acute leukemia patients | Human | LRRC3B | 116135 | leucine rich repeat containing 3B | The results suggest that LRP15 may play an important role in carcinogenesis, AML classification and acute leukemia prognosis. OBJECTIVE: To investigate the methylation status of LRP15 gene in acute leukemia (AL) and its role in tumorigenesis. | Human | SLC22A16 | 85413 | solute carrier family 22 (organic cation/carnitine transporter), member 16 | Quantitative real-time RT-PCR analyses show that SLC22A16 is expressed in primary samples taken from patients with acute leukemia. | Human | BAALC | 79870 | brain and acute leukemia, cytoplasmic | BAALC, the human member of a novel mammalian neuroectoderm gene lineage, is implicated in hematopoiesis and acute leukemia. OBJECTIVE: The gene BAALC (Brain And Acute Leukemia, Cytoplasmic), a novel molecular marker involved in leukemia, is highly expressed in a subset of patients with acute leukemia and predictive of clinical outcome in patients with acute myeloid leukemia and normal karyotype. We show that blasts from a subset of patients with acute leukemia greatly overexpress eight different BAALC transcripts, resulting in five protein isoforms. We describe a human gene in chromosome 8q22.3, BAALC (brain and acute leukemia, cytoplasmic), that is highly conserved among mammals but evidently absent from lower TAX_IDs. | Human | NOM1 | 64434 | nucleolar protein with MIF4G domain 1 | In this report, we describe the characterization of a novel MIF4G/MA3 family member called NOM1 (nucleolar protein with MIF4G domain 1) that was identified at the chromosome 7q36 breakpoint involved in 7;12 translocations associated with certain acute leukemias of childhood. In this report, we describe the characterization of a novel MIF4G/MA3 family member called NOM1 (nucleolar protein with MIF4G domain 1) that was identified at the chromosome 7q36 breakpoint involved in 7;12 translocations associated with certain acute leukemias of childhood. | Human | NOD2 | 64127 | nucleotide-binding oligomerization domain containing 2 | data indicate an unrecognized role for the NOD2/CARD15 gene in unrelated donor hematopoietic stem cell transplantation for acute leukemia; increased risk of disease relapse suggests the wild-type gene product may contribute to graft-versus-leukemia effect | Human | AVEN | 57099 | apoptosis, caspase activation inhibitor | Survivin and aven: two distinct antiapoptotic signals in acute leukemias. CONCLUSIONS: Both survivin and aven are important antiapoptotic signals in acute leukemias, and the association between extramedullary involvement, CD7 expression and CD34 expression, which are important poor prognostic indicators in acute leukemias, suggests that survivin and/or aven may be novel prognostic indicators in acute leukemias. | Human | DIABLO | 56616 | diablo, IAP-binding mitochondrial protein | Moreover, small-molecule agents, resembling Smac/DIABLO in function, were shown to potentiate cytotoxicity of chemotherapy in different malignancies.IAPs, exhibiting downstream influence on both external and intrinsic pathways as well as on some caspase-independent mechanisms of apoptosis, are potentially attractive target for anti-tumor therapy, although their role in the pathology and prognosis of acute leukemia has to be further elucidated. Present studies demonstrate that, upon engagement of the mitochondrial pathway of apoptosis, epothilone (Epo) B derivative BMS 247550, a novel nontaxane antimicrotubule agent, as well as the death ligand Apo-2L/TRAIL (tumor necrosis factor-alpha-related apoptosis-inducing ligand) induce the mitochondrial release and cytosolic accumulation of Smac/DIABLO, along with cyt c, in human acute leukemia Jurkat T cells. Here it is reported that S-1P prevents apoptosis and executioner caspase-3 activation by inhibiting the translocation of cytochrome c and Smac/DIABLO from mitochondria to the cytosol induced by anti-Fas, tumor necrosis factor-alpha (TNF-alpha), serum deprivation, and cell-permeable ceramides in the human acute leukemia Jurkat, U937, and HL-60 cell lines. Hence, S-1P, likely generated through a protein kinase C- mediated activation of sphingosine kinase, inhibits the apoptotic cascade upstream of the release of the mitochondrial apoptogenic factors, cytochrome c, and Smac/DIABLO in human acute leukemia cells. | Human | CHFR | 55743 | checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase | [Expression of mitosis checkpoint gene CHFR in acute leukemia.] Moreover, the aberrant expression of CHFR appears to be a good molecular marker to predict the sensitivity of acute leukemia to chemotherapy. CONCLUSION: By affecting mitotic checkpoint function, CHFR inactivation plays a key role in tumorigenesis in adult patients with acute leukemia. | Human | FBXW7 | 55294 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | There were no mutations in exons 8 or 9 in 160 acute leukemia samples from Korea, in contrast to earlier reports suggesting a role in T-ALL | Human | ANKHD1 | 54882 | ankyrin repeat and KH domain containing 1 | Furthermore, a higher expression of ANKHD1 mRNA was detected in primary acute leukemia samples than in normal hematopoietic cells (P=0.002). ANKHD1, ankyrin repeat and KH domain containing 1, is overexpressed in acute leukemias and is associated with SHP2 in K562 cells. |
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