Human | IL1RAPL2 | 26280 | interleukin 1 receptor accessory protein-like 2 | The increased expression of IL-1 receptor and the colocalization with reciprocal ligands in patients with myositis but not in healthy controls support the hypothesis of a crucial role of IL-1 in the pathogenesis of polymyositis and dermatomyositis |
Human | LILRB1 | 10859 | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 | CD85j(leukocyte Ig-like receptor 1) is expressed in Polymyositis and sporadic Inclusion body myositis at the sites of partial invasion and in Dermatomyositis in perivascular inflammation |
Human | GNLY | 10578 | granulysin | Granulysin expression in CD8 cells seems to be correlated with steroid resistance in polymyositis |
Human | VEGFA | 7422 | vascular endothelial growth factor A | Vascular endothelial growth factor is highly expressed in muscle tissue of patients with polymyositis and patients with dermatomyositis |
Human | TNF | 7124 | tumor necrosis factor | 308G/A promoter polymorphism isassociated with susceptibility to polymyositis/dermatomyositis in a Chinese Han population |
Human | TGM2 | 7052 | transglutaminase 2 | the level of TGase 2 expression was found to be specifically increased in polymyositis and dermatomyositis, but not in Duchenne muscular dystrophy and normal controls immunostaining for TG2 revealed substantial presence of this protein in single, damaged muscle fibers and a weak reaction in regenerating fibers appearing in polymyositis/dermatomyositis patients' specimens |
Human | CCL21 | 6366 | chemokine (C-C motif) ligand 21 | The CCL19,CCL21/CCR7 chemokine system is expressed in inflamed muscles of polymyositis and may be involved in the pathomechanism of polymyositis |
Human | CCL2 | 6347 | chemokine (C-C motif) ligand 2 | genetic markers in the MCP-1 gene do not demonstrate significant genetic associations with the idiopathic inflammatory myopathies and do not discriminate polymyositis from dermatomyositis in a UK Caucasian population |
Human | EXOSC10 | 5394 | exosome component 10 | PM-Scl-75 is the main autoantigen in patients with the polymyositis/scleroderma overlap syndrome |
Human | MMP9 | 4318 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | MMP9 immunoreactivity was present in polymyositis, dermatomyositis and focal myositis |
Human | MMP7 | 4316 | matrix metallopeptidase 7 (matrilysin, uterine) | MMP7 immunoreactivity was present in only polymyositis not dermatomyositis |
Human | MMP2 | 4313 | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | MMP2 immunoreactivity was present in polymyositis and dermatomyositis |
Human | IL15 | 3600 | interleukin 15 | increased production of IL-15 in muscle cells in polymyositis and dermatomyositis |
Human | IL10 | 3586 | interleukin 10 | INFERRED, Score=800, UMLKSK CUI: C0085655 |
Human | IFNB1 | 3456 | interferon, beta 1, fibroblast | Dermatomyositis and polymyositis are diseases characterized by the systemic overexpression of IFNalpha/beta-inducible genes |
Human | IFNA1 | 3439 | interferon, alpha 1 | Dermatomyositis and polymyositis are diseases characterized by the systemic overexpression of IFNalpha/beta-inducible genes |
Human | HMGB1 | 3146 | high mobility group box 1 | The cytoplasmic and extracellular distribution of HMGB-1 in muscle tissue may indicate an important role of this proinflammatory molecule in the pathogenesis of polymyositis and dermatomyositis |
Human | HLA-DRB1 | 3123 | | no correlation between the presence of tumor and major histocompatibility complex class II DR beta 1 (HLA-DRB1)*0301 and *01) alleles was found in patients with Dermatomyositis and polymyositis |
Human | HFE | 3077 | hemochromatosis | heterozygosity for HFE gene C282Y mutation may be a risk factor for juvenile idiopathic arthritis but not for polymyositis and dermatomyositis |
Human | HARS | 3035 | histidyl-tRNA synthetase | Demonstrating histidyl-tRNA synthetase (Jo-1)-specific T cell responses represents a key step in establishing the hypothesis that Jo-1 drives T cell-mediated autoimmunity in Jo-1+ polymyositis |
Human | FAS | 355 | Fas cell surface death receptor | INFERRED, Score=800, UMLKSK CUI: C0085655 |
Human | AGER | 177 | advanced glycosylation end product-specific receptor | data suggests that the CML-RAGE-NF-kappaB pathway is an evident proinflammatory pathomechanism in mononuclear effector cells in polymyositis and dermatomyositis |