Human | IL1RAPL2 | 26280 | interleukin 1 receptor accessory protein-like 2 | The increased expression of IL-1 receptor and the colocalization with reciprocal ligands in patients with myositis but not in healthy controls support the hypothesis of a crucial role of IL-1 in the pathogenesis of polymyositis and dermatomyositis |
Human | LILRB1 | 10859 | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 | CD85j(leukocyte Ig-like receptor 1) is expressed in Polymyositis and sporadic Inclusion body myositis at the sites of partial invasion and in Dermatomyositis in perivascular inflammation |
Human | GNLY | 10578 | granulysin | Granulysin expression in CD8 cells seems to be correlated with steroid resistance in polymyositis |
Human | VEGFA | 7422 | vascular endothelial growth factor A | Vascular endothelial growth factor is highly expressed in muscle tissue of patients with polymyositis and patients with dermatomyositis |
Human | TNF | 7124 | tumor necrosis factor | 308G/A promoter polymorphism isassociated with susceptibility to polymyositis/dermatomyositis in a Chinese Han population |
Human | TGM2 | 7052 | transglutaminase 2 | immunostaining for TG2 revealed substantial presence of this protein in single, damaged muscle fibers and a weak reaction in regenerating fibers appearing in polymyositis/dermatomyositis patients' specimens the level of TGase 2 expression was found to be specifically increased in polymyositis and dermatomyositis, but not in Duchenne muscular dystrophy and normal controls |
Human | CCL21 | 6366 | chemokine (C-C motif) ligand 21 | The CCL19,CCL21/CCR7 chemokine system is expressed in inflamed muscles of polymyositis and may be involved in the pathomechanism of polymyositis |
Human | CCL2 | 6347 | chemokine (C-C motif) ligand 2 | genetic markers in the MCP-1 gene do not demonstrate significant genetic associations with the idiopathic inflammatory myopathies and do not discriminate polymyositis from dermatomyositis in a UK Caucasian population |
Human | EXOSC10 | 5394 | exosome component 10 | PM-Scl-75 is the main autoantigen in patients with the polymyositis/scleroderma overlap syndrome |
Human | MMP9 | 4318 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | MMP9 immunoreactivity was present in polymyositis, dermatomyositis and focal myositis |
Human | MMP7 | 4316 | matrix metallopeptidase 7 (matrilysin, uterine) | MMP7 immunoreactivity was present in only polymyositis not dermatomyositis |
Human | MMP2 | 4313 | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | MMP2 immunoreactivity was present in polymyositis and dermatomyositis |
Human | IL15 | 3600 | interleukin 15 | increased production of IL-15 in muscle cells in polymyositis and dermatomyositis |
Human | IL10 | 3586 | interleukin 10 | INFERRED, Score=800, UMLKSK CUI: C0085655 |
Human | IFNB1 | 3456 | interferon, beta 1, fibroblast | Dermatomyositis and polymyositis are diseases characterized by the systemic overexpression of IFNalpha/beta-inducible genes |
Human | IFNA1 | 3439 | interferon, alpha 1 | Dermatomyositis and polymyositis are diseases characterized by the systemic overexpression of IFNalpha/beta-inducible genes |
Human | HMGB1 | 3146 | high mobility group box 1 | The cytoplasmic and extracellular distribution of HMGB-1 in muscle tissue may indicate an important role of this proinflammatory molecule in the pathogenesis of polymyositis and dermatomyositis |
Human | HLA-DRB1 | 3123 | | no correlation between the presence of tumor and major histocompatibility complex class II DR beta 1 (HLA-DRB1)*0301 and *01) alleles was found in patients with Dermatomyositis and polymyositis |
Human | HFE | 3077 | hemochromatosis | heterozygosity for HFE gene C282Y mutation may be a risk factor for juvenile idiopathic arthritis but not for polymyositis and dermatomyositis |
Human | HARS | 3035 | histidyl-tRNA synthetase | Demonstrating histidyl-tRNA synthetase (Jo-1)-specific T cell responses represents a key step in establishing the hypothesis that Jo-1 drives T cell-mediated autoimmunity in Jo-1+ polymyositis |
Human | FAS | 355 | Fas cell surface death receptor | INFERRED, Score=800, UMLKSK CUI: C0085655 |
Human | AGER | 177 | advanced glycosylation end product-specific receptor | data suggests that the CML-RAGE-NF-kappaB pathway is an evident proinflammatory pathomechanism in mononuclear effector cells in polymyositis and dermatomyositis |