Human | DNAJC19 | 131118 | DnaJ (Hsp40) homolog, subfamily C, member 19 | |
Human | ALG10 | 84920 | ALG10, alpha-1,2-glucosyltransferase | |
Human | PRKAG2 | 51422 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | Possible increased risk of sudden cardiac death |
Human | ROCK2 | 9475 | Rho-associated, coiled-coil containing protein kinase 2 | results indicate that remnant-like particles from sudden cardiac death patients upregulate Rho-kinase in coronary vascular smooth muscle cells and markedly enhance coronary vasospastic activity |
Human | CSRP3 | 8048 | cysteine and glycine-rich protein 3 (cardiac LIM protein) | |
Human | USF1 | 7391 | upstream transcription factor 1 | USF1 contributes to atherosclerosis, the pathological arterial wall phenotype resulting in coronary heart disease and in its most dramatic consequence-sudden cardiac death |
Human | SCN5A | 6331 | sodium channel, voltage-gated, type V, alpha subunit | This suggests that genetic determinants located in KCNQ1, KCNE1, KCNH2 and SCN5A influence QTc length in healthy individuals and may represent risk factors for arrhythmias or cardiac sudden death in patients with cardiovascular diseases Functionally significant mutations and rare variants in SCN5A may contribute to sudden cardiac death risk among women The Y1102 allele is a risk factor in blacks for sudden cardiac death in the absence of obvious morphological findings or mild to moderate cardiomegaly |
Human | ROCK1 | 6093 | Rho-associated, coiled-coil containing protein kinase 1 | results indicate that remnant-like particles from sudden cardiac death patients upregulate Rho-kinase in coronary vascular smooth muscle cells and markedly enhance coronary vasospastic activity |
Human | PKP2 | 5318 | plakophilin 2 | |
Human | LMNA | 4000 | lamin A/C | Increased risk of sudden cardiac death |
Human | LIPC | 3990 | lipase, hepatic | results suggest that HL C-480T polymorphism is a strong age-dependent risk factor of sudden cardiac death in early middle-aged men |
Human | KCNQ1 | 3784 | potassium voltage-gated channel, KQT-like subfamily, member 1 | |
Human | KCNJ11 | 3767 | potassium inwardly-rectifying channel, subfamily J, member 11 | In this study of acute myocardial infarct patients, sudden cardiac death was not related to polymorphisms in the KCNJ11 gene The result suggests that the Kir6.2/KCNJ11 gene is not related to sudden cardiac death in this family |
Human | KCNH2 | 3757 | potassium voltage-gated channel, subfamily H (eag-related), member 2 | In 2 of 3 families with hereditary short-QT syndrome and a high incidence of ventricular arrhythmias and sudden cardiac death,we identified 2 different missense mutations in the cardiac IKr channel HERG (KCNH2) |
Human | KCNE1 | 3753 | potassium voltage-gated channel, Isk-related family, member 1 | |
Human | ITGB3 | 3690 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | Title:Glycoprotein IIIa Pl(A1/A2) polymorphism and sudden cardiac death.|Association:Not Found|Conclusion:Our results suggest that the A2 allele of the Pl(A1/A2) polymorphism of GPIIIa is a major risk factor of coronary thrombosis and may be one important predictor of SCD in early middle age. |
Human | IL18 | 3606 | interleukin 18 (interferon-gamma-inducing factor) | IL-18 promoter -137G/C polymorphism, which regulates the expression of IL-18, is an important predictor of sudden cardiac death from any cause as well as SCD in patients with and without underlying coronary heart disease |
Human | GNAI2 | 2771 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 | |
Human | DSP | 1832 | desmoplakin | |
Human | DSG2 | 1829 | desmoglein 2 | |
Human | CACNB2 | 783 | calcium channel, voltage-dependent, beta 2 subunit | loss-of-function mutations in genes encoding the cardiac L-type calcium channel to be associated with a familial sudden cardiac death syndrome in which a Brugada syndrome phenotype is combined with shorter-than-normal QT intervals |
Human | CACNA2D1 | 781 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | loss-of-function mutations in genes encoding the cardiac L-type calcium channel to be associated with a familial sudden cardiac death syndrome in which a Brugada syndrome phenotype is combined with shorter-than-normal QT intervals |
Human | CACNA1C | 775 | calcium channel, voltage-dependent, L type, alpha 1C subunit | loss-of-function mutations in genes encoding the cardiac L-type calcium channel to be associated with a familial sudden cardiac death syndrome in which a Brugada syndrome phenotype is combined with shorter-than-normal QT intervals |
Human | ANXA5 | 308 | annexin A5 | The -1C to T polymorphism in the annexin A5 gene is not associated with the risk of acute myocardial infarction or sudden cardiac death in middle-aged Finnish males |
Human | ANK2 | 287 | ankyrin 2, neuronal | |