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Details
Link-It Detail - Disease - Primary Ovarian Insufficiency
Debug Stats
  • ### Total Build Time: 473 ms 52.938 KB
  • CONCEPT_NAME gt=7 ms Completed: 7 ms rowSize= 412 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 1.059 KB
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 188 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=8 ms Completed: 8 ms rowSize= 552 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=18 ms Completed: 18 ms rowSize= 2.814 KB
  • CONCEPT_RELATIONSHIPS gt=375 ms Completed: 375 ms rowSize= 13.681 KB
  • CONCEPT_GENES gt=55 ms Completed: 55 ms rowSize= 33.062 KB
  • CONCEPT_XREFS gt=9 ms Completed: 9 ms rowSize= 1.163 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Disease (2)
Primary Ovarian Insufficiency C0085215
Ovarian Failure, Premature
Definition (1)

Premature ovarian failure (POF) is when a woman's ovaries stop working before she is 40. POF used to be called premature menopause. However, POF is not the same as menopause. Some women with POF still have occasional periods. Premature menopause is when periods stop before age of 40. This can be natural or caused by surgery, chemotherapy or radiation.

Missed periods are usually the first sign of POF. Later symptoms may be similar to those of natural menopause.

Most women with POF cannot get pregnant naturally. Fertility treatments help a few women; others use donor eggs to have children. There is no treatment that will restore normal ovarian function. However, many health care providers suggest taking hormones until age 50.

NIH: National Institute of Child Health and Human Development

Semantic Types (1)
Disease or Syndrome (T047)
Parents (1)
img Ovarian Diseases C0029928
Ancestral Roots
RootRoot Plus OneDepthParent
img Female Urogenital Diseases and Pregnancy Complications C1720765img Female Urogenital Diseases C17208876img Ovarian Diseases C0029928
img Endocrine System Diseases C0014130img Gonadal Disorders C00180504img Ovarian Diseases C0029928
Relationships (164)

Relation Types:
diso_​to_​anat : 7
diso_​to_​chem : 124
diso_​to_​diso : 23
diso_​to_​gene : 1
diso_​to_​phen : 2
diso_​to_​phys : 7


Relationships:
none : 38
mapped_​to : 10
may_​treat : 113
related_​to : 3
Page Size
Current 25
  Page 1 of 7
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_PHEN223img genetic aspects C0017399
DISO_to_PHEN105img genetic aspects C0017399
DISO_to_ANAT74img Ovary C0029939
DISO_to_DISO71img chemically induced C0007994
DISO_to_ANAT52img In Blood C0005768
DISO_to_DISO50img Complication Aspects C1171258
DISO_to_DISO50img Infertility, Female C0021361
DISO_to_DISO35img Complication Aspects C1171258
DISO_to_ANAT33img Chromosomes, Human, X C1136735
DISO_to_ANAT33img Ovary C0029939
DISO_to_DISO32img chemically induced C0007994
DISO_to_CHEM31img Antineoplastic Agents C0003392
DISO_to_CHEM31img Fragile X Mental Retardation Protein C0118036
DISO_to_PHYS28img Mutation C0026882
DISO_to_ANAT26img In Blood C0005768
DISO_to_CHEM24img Gonadorelin C0023610
DISO_to_CHEM24img Gonadotropin-Releasing Hormone C0023610
DISO_to_ANAT23img Chromosome, Human X C1136735
DISO_to_PHYS21img Fertility C0015895
DISO_to_ANAT20img Ovarian Follicle C0018120
DISO_to_DISO19img Female infertility C0021361
DISO_to_DISO19img Neoplasms C0027651
DISO_to_DISO17img FRAGILE X MENTAL RETARDATION SYNDROME C0016667
DISO_to_CHEM16img Forkhead Box Proteins C0118111
DISO_to_GENE16img Polymorphism, Single Nucleotide C0752046
Genes (41)

Species:
human : 41
Page Size
Current 25
  Page 1 of 2
Prior Page
Current 1
SpeciesGeneGeneIdGene NameEvidence
HumanLHX8431707LIM homeobox 8
img GENERIF, Score=1000, Pubmed Id: 17624344, UMLKSK CUI: C0085215
HumanNANOS3342977nanos homolog 3 (Drosophila)
img GENERIF, Score=1000, Pubmed Id: 17418157, UMLKSK CUI: C0085215
HumanH19283120H19, imprinted maternally expressed transcript (non-protein coding)
img GENERIF, Score=861, Pubmed Id: 16708166, UMLKSK CUI: C0085215
HumanNOBOX135935NOBOX oogenesis homeobox
img GENERIF, Score=1000, Pubmed Id: 15950662, UMLKSK CUI: C0085215
img GENERIF, Score=1000, Pubmed Id: 17701902, UMLKSK CUI: C0085215
HumanNLRP5126206NLR family, pyrin domain containing 5
img GENERIF, Score=923, Pubmed Id: 11925379, UMLKSK CUI: C0085215
HumanDACH2117154dachshund homolog 2 (Drosophila)
img GAD, Score=1000, Pubmed Id: 15459172, UMLKSK CUI: C0085215
HumanPOF1B79983premature ovarian failure, 1B
img GENERIF, Score=1000, Pubmed Id: 15459172, UMLKSK CUI: C0085215
HumanBBS927241Bardet-Biedl syndrome 9
img GENERIF, Score=1000, Pubmed Id: 18349106, UMLKSK CUI: C0085215
HumanSPO1123626SPO11 meiotic protein covalently bound to DSB
img GENERIF, Score=1000, Pubmed Id: 18166824, UMLKSK CUI: C0085215
HumanSETX23064senataxin
img GENERIF, Score=901, Pubmed Id: 17593543, UMLKSK CUI: C0085215
HumanDMC111144DNA meiotic recombinase 1
img GENERIF, Score=1000, Pubmed Id: 18166824, UMLKSK CUI: C0085215
HumanPGRMC110857progesterone receptor membrane component 1
img GENERIF, Score=1000, Pubmed Id: 18782852, UMLKSK CUI: C0085215
HumanBMP159210bone morphogenetic protein 15
img GENERIF, Score=1000, Pubmed Id: 17027369, UMLKSK CUI: C0085215
img GENERIF, Score=1000, Pubmed Id: 16645022, UMLKSK CUI: C0085215
img GENERIF, Score=1000, Pubmed Id: 16508750, UMLKSK CUI: C0085215
img GENERIF, Score=1000, Pubmed Id: 17826728, UMLKSK CUI: C0085215
HumanEIF2B58893eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
img OMIM, Score=1000, UMLKSK CUI: C0085215
HumanEIF2B28892eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
img OMIM, Score=1000, UMLKSK CUI: C0085215
HumanEIF2B38891eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
img OMIM, Score=1000, UMLKSK CUI: C0085215
HumanEIF2B48890eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
img OMIM, Score=1000, UMLKSK CUI: C0085215
HumanTGFBR37049transforming growth factor, beta receptor III
img GENERIF, Score=1000, Pubmed Id: 17084394, UMLKSK CUI: C0085215
HumanRPL106134ribosomal protein L10
img GENERIF, Score=964, Pubmed Id: 17566674, UMLKSK CUI: C0085215
HumanPOLG5428polymerase (DNA directed), gamma
img GENERIF, Score=901, Pubmed Id: 16595552, UMLKSK CUI: C0085215
img OMIM, Score=1000, UMLKSK CUI: C0085215
HumanMSH54439mutS homolog 5 (E. coli)
img GENERIF, Score=1000, Pubmed Id: 18166824, UMLKSK CUI: C0085215
HumanMSH44438mutS homolog 4 (E. coli)
img GENERIF, Score=1000, Pubmed Id: 18166824, UMLKSK CUI: C0085215
HumanKITLG4254KIT ligand
img GENERIF, Score=884, Pubmed Id: 16647379, UMLKSK CUI: C0085215
HumanINHBB3625inhibin, beta B
img GENERIF, Score=1000, Pubmed Id: 15205401, UMLKSK CUI: C0085215
img GENERIF, Score=1000, Pubmed Id: 15562017, UMLKSK CUI: C0085215
img GENERIF, Score=1000, Pubmed Id: 15374731, UMLKSK CUI: C0085215
HumanINHBA3624inhibin, beta A
img GENERIF, Score=1000, Pubmed Id: 15374731, UMLKSK CUI: C0085215
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0085215Primary Ovarian Insufficiency0self