Debug Stats | ### Total Build Time: 110 ms 39.722 KB CONCEPT_NAME gt=10 ms Completed: 10 ms rowSize= 368 bytesCONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytesCONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 216 bytes- Skipping details on:
CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes - Skipping details on:
CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 187 bytes- Skipping details on:
CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes CONCEPT_PARENTS gt=13 ms Completed: 13 ms rowSize= 557 bytesCONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytesCONCEPT_ANCESTRAL_ROOTS gt=13 ms Completed: 13 ms rowSize= 4.072 KBCONCEPT_RELATIONSHIPS gt=48 ms Completed: 48 ms rowSize= 16.242 KBCONCEPT_GENES gt=19 ms Completed: 19 ms rowSize= 16.906 KBCONCEPT_XREFS gt=6 ms Completed: 6 ms rowSize= 1.169 KBCONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes- Reload Stats
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Relationships (49)
Relation Types: diso_to_anat : 24 diso_to_diso : 24 diso_to_phen : 1
Relationships: none : 8 associated_with : 1 is_abnormal_cell_of_disease : 7 is_associated_anatomic_site_of : 1 is_finding_of_disease : 1 is_normal_cell_origin_of_disease : 4 is_normal_tissue_origin_of_disease : 2 is_not_abnormal_cell_of_disease : 3 is_not_finding_of_disease : 1 is_not_molecular_abnormality_of_disease : 1 is_not_normal_cell_origin_of_disease : 4 is_primary_anatomic_site_of_disease : 1 isa : 5 may_be_abnormal_cell_of_disease : 1 may_be_cytogenetic_abnormality_of_disease : 2 may_be_finding_of_disease : 2 may_be_molecular_abnormality_of_disease : 4 permuted_term_of : 1 | |
DISO_to_DISO | 11 | |
AIDS ASSOC LYMPHOMA C0085090 | DISO_to_DISO | 10 | |
Complication Aspects C1171258 | DISO_to_PHEN | 10 | |
genetic aspects C0017399 | DISO_to_ANAT | 7 | |
Plasma Cells C0032112 | DISO_to_DISO | 7 | |
Diffuse Large B-Cell Lymphoma C0079744 | DISO_to_DISO | 6 | |
Mouth Neoplasms C0026640 | DISO_to_DISO | 5 | |
B-Cell Lymphomas C0079731 | DISO_to_DISO | 5 | |
HIV Infections C0019693 | DISO_to_ANAT | | is_abnormal_cell_of_disease |
Atypical lymphocyte C0221277 | DISO_to_ANAT | | is_not_normal_cell_origin_of_disease |
B lymphoblast C1516097 | DISO_to_ANAT | | is_normal_cell_origin_of_disease |
B-Lymphocytes C0004561 | DISO_to_ANAT | | is_not_abnormal_cell_of_disease |
Cells, Reed-Sternberg C0085133 | DISO_to_ANAT | | is_normal_tissue_origin_of_disease |
HEMOLYMPHORETICULAR TISSUE C1512398 | DISO_to_ANAT | | is_associated_anatomic_site_of |
Hematopoietic and Lymphatic System C1512394 | DISO_to_ANAT | | is_normal_cell_origin_of_disease |
Hematopoietic and Lymphoid Cell C1512385 | DISO_to_ANAT | | is_primary_anatomic_site_of_disease |
Lymphatic System C0024235 | DISO_to_ANAT | | is_normal_tissue_origin_of_disease |
Lymphatic Tissue C0024296 | DISO_to_ANAT | | is_normal_cell_origin_of_disease |
Lymphocyte C0024264 | DISO_to_ANAT | | is_normal_cell_origin_of_disease |
Mature B-Cell C1513019 | DISO_to_ANAT | | is_not_normal_cell_origin_of_disease |
Myeloid Cells C0887899 | DISO_to_ANAT | | is_abnormal_cell_of_disease |
Neoplastic B-Immunoblast C1513927 | DISO_to_ANAT | | is_abnormal_cell_of_disease |
Neoplastic B-Lymphocyte C1513929 | DISO_to_ANAT | | is_abnormal_cell_of_disease |
Neoplastic Cell C0597032 | DISO_to_ANAT | | may_be_abnormal_cell_of_disease |
Neoplastic Centroblast C1514006 | DISO_to_ANAT | | is_abnormal_cell_of_disease |
Neoplastic Hematopoietic and Lymphoid Cell C1513983 |
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Genes (10)
Species: human : 9 mouse : 1 | |
Mouse | LYN | 4067 | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog | Previously, we reported that the K1 protein induced plasmablastic lymphomas in K1 transgenic mice, and that these lymphomas showed enhanced Lyn kinase activity. | Human | TIMP1 | 7076 | TIMP metallopeptidase inhibitor 1 | Further studies are presented on eighteen cases of high grade, large cell immunoblastic lymphoma in which expression at the RNA level of TIMP-1 and the metalloproteinase, 92 kDa gelatinase, were analyzed. Relationship between the clinical aggressiveness of large cell immunoblastic lymphomas and expression of 92 kDa gelatinase (type IV collagenase) and tissue inhibitor of metalloproteinases-1 (TIMP-1) RNAs. | Human | TFRC | 7037 | transferrin receptor (p90, CD71) | However, transferrin receptor expression by certain histologic subtypes of lymphoma did not correlate with their morphologic grade: low-grade follicular lymphomas expressed the T9 antigen more frequently than diffuse low-grade lymphomas; diffuse small cleaved cell lymphomas were stained by OKT9 less often than other histologic subtypes of intermediate-grade lymphomas; and diffuse immunoblastic lymphomas expressed transferrin receptors less often than the other high-grade histologic subtypes of non-Hodgkins lymphoma. In attempting to identify antigens that are differentially expressed on tumor cells following transformation from follicular small cleaved cell lymphoma (FSC) to immunoblastic lymphoma (IL), we identified a unique epitope of the transferrin receptor (TfR). | Human | SPN | 6693 | sialophorin | The large cell immunoblastic lymphoma was of T-cell lineage, positive for the CD45RB, CD3, CD45RO, and CD43 antigens, and negative for the CD20 and CDw75 antigens. | Human | SDC1 | 6382 | syndecan 1 | All cases of plasmablastic lymphoma and plasmablastic plasma cell myeloma were positive for MUM1/IRF4, CD138, and CD38, and negative for CD20, corresponding to a plasma cell immunophenotype. | Human | PAX5 | 5079 | paired box 5 | PAX-5 and BCL-6 were weakly positive in 2/9 and 1/5 plasmablastic lymphomas, and negative in all plasmablastic plasma cell myelomas. | Human | KIT | 3815 | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | CD117 expression can be detected sporadically in DLBCL (diffuse large B-cell lymphoma) of follicle center-cell origin and a subset of plasmablastic lymphomas | Human | IL9 | 3578 | interleukin 9 | However, it appears that IL-6 and/or IL-9 may play a prominent role in the tumor cell proliferation of Hodgkin;s disease (HD), anaplastic large-cell lymphoma, or immunoblastic lymphoma. | Human | CD22 | 933 | CD22 molecule | With the exception of some lymphoblastic lymphomas, high-grade B-cell lymphomas normally expressed the pan B-cell antigens CD19 and CD22 but only immunoblastic lymphomas consistently expressed the pan B marker CD20. | Human | MS4A1 | 931 | membrane-spanning 4-domains, subfamily A, member 1 | A skin biopsy led to the diagnosis of plasmablastic lymphoma in view of the presence of a dense nodular infiltrate invading the dermis and subcutaneous fat composed of large cells that expressed neither the leucocyte common antigen nor the B- and T-cell antigens CD20 and CD3, but which showed a strong immunostaining with plasma cell marker VS38c. All cases of plasmablastic lymphoma and plasmablastic plasma cell myeloma were positive for MUM1/IRF4, CD138, and CD38, and negative for CD20, corresponding to a plasma cell immunophenotype. Histologic examination of lesional tissue revealed a lymphoid tumor with a high proliferation rate containing lymphoplasmacytoid cells that were reactive to the plasma cell marker VS38c but not to CD20 or CD79a; these are features of the recently reported non-Hodgkin;s lymphoma termed plasmablastic lymphoma. The large cell immunoblastic lymphoma was of T-cell lineage, positive for the CD45RB, CD3, CD45RO, and CD43 antigens, and negative for the CD20 and CDw75 antigens. With the exception of some lymphoblastic lymphomas, high-grade B-cell lymphomas normally expressed the pan B-cell antigens CD19 and CD22 but only immunoblastic lymphomas consistently expressed the pan B marker CD20. |
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