Genes (37)
Species: human : 36 mouse : 1 | |
Mouse | PLAG1 | 5324 | pleiomorphic adenoma gene 1 | Salivary Gland Tumors in Transgenic Mice with Targeted PLAG1 Proto-Oncogene Overexpression. [Development of salivary gland tumors in pleomorphic adenoma gene 1 transgenic mice] | Human | MAML2 | 84441 | mastermind-like 2 (Drosophila) | MAM-3 and MAM-6 antigens of human milk fat globule membrane were detected immunohistochemically in 93 cases of salivary gland tumours as well as in normal glands. Immunohistochemical expression of MAM-3 and MAM-6 antigens in salivary gland tumours. | Human | ARHGAP23 | 57636 | Rho GTPase activating protein 23 | ARHGAP23 mRNA was expressed in placenta, prostate, hippocampus, brain medulla as well as in brain tumor, salivary gland tumor, head and neck tumor. | Human | KRT20 | 54474 | keratin 20 | salivary gland neoplasms showed a CK7+/CK20- immunoprofile ranging from 5 to 100%; squamous carcinoma showed negative CK7/20 immunoexpression | Human | KLK13 | 26085 | kallikrein-related peptidase 13 | hK13 is expressed in several common salivary gland tumors | Human | KLK5 | 25818 | kallikrein-related peptidase 5 | Human kallikrein 3 (Prostate Specific Antigen) and human kallikrein 5 expression in salivary gland tumors. | Human | TSC22D1 | 8848 | TSC22 domain family, member 1 | The mRNA expression of TSC-22 in benign and malignant salivary gland tumors was significantly decreased when compared to that in tumor-free salivary glands (P < 0.05; one-way ANOVA), and in some salivary gland tumors, the expression of TSC-22 mRNA was not detectable by reverse transcription-PCR. Furthermore, we examined the expression of TSC-22 mRNA in several human salivary gland tumors. CONCLUSIONS: Significantly decreased levels of TSC-22 mRNA in human brain and salivary gland tumors and antiproliferative role of TSC-22 strongly suggest a tumor suppressor role for TSC-22. | Human | WISP2 | 8839 | WNT1 inducible signaling pathway protein 2 | Results suggest that WISP-2 could be a reliable independent marker and that down-regulation or loss of the WISP-2 gene may be associated with the development of salivary gland tumors | Human | TP63 | 8626 | tumor protein p63 | Differential expression of p63 isotypes (DeltaN and TA) in salivary gland neoplasms: biological and diagnostic implications. Among 68 representative salivary gland tumors, 63 displayed p63 reactivity. Expression profiles of p53, p63, and p73 in benign salivary gland tumors. Assessment of p63 expression in the salivary gland neoplasms adenoid cystic carcinoma, polymorphous low-grade adenocarcinoma, and basal cell and canalicular adenomas. Expression and mutation of p53, p73, and p63 were examined by direct DNA sequencing, reverse transcription PCR using isoform-specific primers, and by immunohistochemistry in normal parotid tissue ( n=10), and various tumors of the salivary gland (42 pleomorphic adenomas, 12 myoepitheliomas, 8 basal cell adenomas, 5 oncocytomas, 5 canalicular adenomas, and 20 adenolymphomas). We conclude that (1) p63 isoforms are differentially expressed in most benign and malignant tumors and may play distinct biological roles in certain salivary gland neoplasms; (2) p63 immunostaining do not correlate with the isoforms expression; and (3) isoform-specific antibodies are required for better cellular localization and biological correlations. In contrast, in salivary gland tumors, strong nuclear staining for p63 and p73 was observed. Our data indicate that p63 and p73 are upregulated in salivary gland tumors and may serve as a marker of epithelial and myoepithelial progenitor cells in salivary glands. This study was performed to examine the expression of p53, p63, and p73 in benign salivary gland tumors. PURPOSE: The purpose of this study was to determine the extent of p63 immunoreactivity in the malignant salivary gland neoplasms adenoid cystic carcinoma (ACC) and polymorphous low-grade adenocarcinoma (PLGA) and to compare this to the expression of this marker in the benign salivary gland tumors canalicular adenoma and basal cell adenoma. Few studies on the expression of p63 in head and neck salivary gland tumors have been published to date. p63 expression is retained in the modified myoepithelial and basal cells of human salivary gland tumors, which suggests a role for p63 in oncogenesis of these complex tumors. | Human | SDC1 | 6382 | syndecan 1 | Syndecan-1 and beta1 integrin signaling downstream of laminin alpha1-derived peptide AG73 regulate adhesion and MMP production by human salivary gland tumor cell lines (CAC2 and M1) | Human | RBL2 | 5934 | retinoblastoma-like 2 (p130) | Expression of Cell Cycle-Regulated Proteins pRB2/p130, p107, E2F4, p27, and pCNA in Salivary Gland Tumors: Prognostic and Diagnostic Implications. | Human | KLK6 | 5653 | kallikrein-related peptidase 6 | Results of this study show that salivary gland tumors express hK6, apparently downregulated in comparison with normal salivary gland tissue, and that this expression is not specific for any of the tumors studied. The aim of this study was to determine whether hK6 is expressed in salivary gland tissues and salivary gland tumors (both benign and malignant), using an immunohistochemical method. | Human | PLAG1 | 5324 | pleiomorphic adenoma gene 1 | Conserved mechanism of PLAG1 activation in salivary gland tumors with and without chromosome 8q12 abnormalities: identification of SII as a new fusion partner gene. We have performed reverse transcriptase-PCR and Northern blot analyses to study the expression of PLAG1 in normal salivary gland tissues and in primary cultures and cell lines derived from salivary gland tumors. Our data indicate that the presence or absence of PLAG1 expression is not an unequivocal marker for the differential diagnosis of benign versus malignant salivary gland tumors, and that a simple de novo activation of this gene does not fully explain the involvement of this gene in salivary gland tumors. Our findings establish a conserved mechanism of PLAG1 activation in salivary gland tumors with and without 8q12 aberrations, which indicates that such activation is a frequent event in these tumors. These results provide us with the first clue for understanding the role of PLAG1 in salivary gland tumor development. CONCLUSION: Overexpression of PLAG1 gene plays a crucial role in tumorigenesis of salivary gland tumors. In contrast, PLAG1 was overexpressed in only 2 of 11 malignant salivary gland tumors analyzed, which suggests that, at least in salivary gland tumors, PLAG1 activation preferentially occurs in benign tumors. RESULTS: It was found that the human PLAG1 cDNA cloned from several salivary gland tumor and normal placenta tissues consistently showed a variation of a single nucleotide at the same position when compared with the human PLAG1 cDNA sequence in Genbank (Accession No. Molecular analyses in salivary gland tumors revealed that ring formation consistently generated novel FGFR1-PLAG1 gene fusions in which the 5'-part of FGFR1 is linked to the coding sequence of PLAG1 All of these results strongly suggest that IGF-II is one of the PLAG1 target genes, providing us with the first clue for understanding the role of PLAG1 in salivary gland tumor development. | Human | PDYN | 5173 | prodynorphin | In addition, neuropeptides, such as vasoactive intestinal polypeptide, somatostatin, and substance P, in human salivary gland neoplasms were expressed, whereas other polypeptides, including glucagon, cholecystokinin, leu-enkephalin and calcitonin, were absent. | Human | PC | 5091 | pyruvate carboxylase | To clarify the pathologic value of endogenous biotin in the salivary gland, we examined in a series of neoplasms of the salivary gland by immunohistochemical staining the distribution of endogenous biotin and of biotin-binding enzymes, namely, acetyl CoA carboxylase (AC), which is a cytosolic enzyme, and pyruvate carboxylase (PC), which is a mitochondrial enzyme. | Human | NOTCH4 | 4855 | notch 4 | Microsatellite polymorphism of (CTG)n repeat in the signal peptide domain of NOTCH4 was analyzed in Japanese including the patients with salivary gland tumor. Triplet repeat polymorphism in the NOTCH4 gene with the human major histocompatibility complex in a healthy population and patients with a salivary gland tumor in Japan. | Human | NOS3 | 4846 | nitric oxide synthase 3 (endothelial cell) | Limited expression of ecNOS was found in all the salivary gland tumors examined. | Human | NME1 | 4830 | NME/NM23 nucleoside diphosphate kinase 1 | METHODS: Expression of P16 and nm23 proteins was examined by SABC immunohistochemical method in 39 cases of paraffin blocks of normal salivary gland tissues and salivary gland tumors. OBJECTIVE: To study the expression of p16 and nm23 genes in salivary gland tumors and the relation of P16 and nm23 proteins with fumorigenesis of salivary gland tumors. There was no correlation of the expression of P16 and nm23 in salivary gland tumors was found (P > 0.05). There was no correlation of the expression of P16 and nm23 in salivary gland tumors was found (P > 0.05). Immunohistochemical localization of the NM23 protein in salivary gland neoplasms with distinct biological behavior. [Expression of p16 and nm23 genes in salivary gland tumors] | Human | NCAM1 | 4684 | neural cell adhesion molecule 1 | NCAM is associated not only with a cell-to-cell adhesion mechanism, but also with tumorigenesis, including growth, development and perineural invasion in human salivary gland tumors | Human | MUC2 | 4583 | mucin 2, oligomeric mucus/gel-forming | expression pattern of MUC2 in salivary gland neoplasia may be of value for the classification of salivary gland tumors | Human | MUC1 | 4582 | mucin 1, cell surface associated | All salivary gland tumors expressed MUC1 | Human | MDM2 | 4193 | MDM2 oncogene, E3 ubiquitin protein ligase | overexpression is related to the tumorigenesis and/or tumour progression of salivary gland neoplasms | Human | MCM2 | 4171 | minichromosome maintenance complex component 2 | may be a sensitive proliferation marker in salivary gland tumours | Human | MAGEA1 | 4100 | melanoma antigen family A, 1 (directs expression of antigen MZ2-E) | This study aimed to analyse the expression of putative tumour suppressor genes, FHIT and WT-1, and tumour rejection genes, BAGE, GAGE-1/2, MAGE-1, MAGE-3, and HAGE (which are reported to be important in human cancers), in salivary gland neoplasms. | Human | KRT7 | 3855 | keratin 7 | salivary gland neoplasms showed a CK7+/CK20- immunoprofile ranging from 5 to 100%; squamous carcinoma showed negative CK7/20 immunoexpression |
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