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Details
Link-It Detail - Disease - Rheumatoid Nodule
Debug Stats
  • ### Total Build Time: 31 ms 25.725 KB
  • CONCEPT_NAME gt=3 ms Completed: 3 ms rowSize= 380 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 508 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 188 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=5 ms Completed: 5 ms rowSize= 557 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 5.354 KB
  • CONCEPT_RELATIONSHIPS gt=3 ms Completed: 3 ms rowSize= 8.403 KB
  • CONCEPT_GENES gt=17 ms Completed: 17 ms rowSize= 9.186 KB
  • CONCEPT_XREFS gt=1 ms Completed: 1 ms rowSize= 1.151 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Disease (2)
Rheumatoid Nodule C0035450
Nodule, Rheumatoid
Definition (1)
Subcutaneous nodules seen in 20-30% of rheumatoid arthritis patients. They may arise anywhere on the body, but are most frequently found over the bony prominences. The nodules are characterized histologically by dense areas of fibrinoid necrosis with basophilic streaks and granules, surrounded by a palisade of cells, mainly fibroblasts and histiocytes.
Semantic Types (1)
Pathologic Function (T046)
Parents (1)
img Arthritis, Rheumatoid C0003873
Ancestral Roots
RootRoot Plus OneDepthParent
img Musculoskeletal Diseases C0026857img Joint Diseases C00224085img Arthritis, Rheumatoid C0003873
img Immune System Diseases C0021053img Autoimmune Diseases C00043644img Arthritis, Rheumatoid C0003873
img Musculoskeletal Diseases C0026857img Rheumatic Diseases C00354354img Arthritis, Rheumatoid C0003873
img Skin and Connective Tissue Diseases C0175166img Connective Tissue Diseases C00097825img Arthritis, Rheumatoid C0003873
Relationships (19)

Relation Types:
diso_​to_​anat : 1
diso_​to_​chem : 3
diso_​to_​diso : 14
diso_​to_​phen : 1


Relationships:
none : 15
isa : 2
location_​of : 1
permuted_​term_​of : 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_DISO22img Complication Aspects C1171258
DISO_to_DISO21img Arthritis, Rheumatoid C0003873
DISO_to_DISO19img Arthritis, Rheumatoid C0003873
DISO_to_DISO11img Lung Diseases C0024115
DISO_to_CHEM10img Antirheumatic Agents C0003191
DISO_to_DISO10img Complication Aspects C1171258
DISO_to_CHEM9img Antirheumatic Agents C0003191
DISO_to_DISO8img Lung Diseases C0024115
DISO_to_DISO8img chemically induced C0007994
DISO_to_CHEM4img Methotrexate C0025677
DISO_to_DISO4img Granuloma C0018188
DISO_to_DISO4img Pneumothorax C0032326
DISO_to_PHEN4img genetic aspects C0017399
DISO_to_ANATlocation_ofimg Subcutaneous Tissue C0278403
DISO_to_DISOisaimg Accelerated rheumatoid nodulosis C1304215
DISO_to_DISOimg Arthritis, Rheumatoid C0003873
DISO_to_DISOimg Juvenile RA, Poly-articular Onset C0151457
DISO_to_DISOisaimg Linear subcutaneous bands in rheumatoid disease C1276119
DISO_to_DISOpermuted_term_ofimg Nodule, Rheumatoid C0035450
Genes (10)

Species:
human : 10
SpeciesGeneGeneIdGene NameEvidence
HumanCD27429126CD274 molecule
img GENERIF, Score=1000, Pubmed Id: 17597384, UMLKSK CUI: C0035450
HumanPTPN2226191protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
img OMIM, Score=1000, UMLKSK CUI: C0035450
HumanPADI423569peptidyl arginine deiminase, type IV
img OMIM, Score=1000, UMLKSK CUI: C0035450
HumanSTAT46775signal transducer and activator of transcription 4
img OMIM, Score=1000, UMLKSK CUI: C0035450
HumanSLC22A46583solute carrier family 22 (organic cation/zwitterion transporter), member 4
img OMIM, Score=1000, UMLKSK CUI: C0035450
HumanNFKBIL14795nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
img OMIM, Score=1000, UMLKSK CUI: C0035450
HumanCIITA4261class II, major histocompatibility complex, transactivator
img OMIM, Score=1000, UMLKSK CUI: C0035450
HumanIL103586interleukin 10
img OMIM, Score=1000, UMLKSK CUI: C0035450
HumanHLA-DRB13123
img OMIM, Score=1000, UMLKSK CUI: C0035450
HumanRUNX1861runt-related transcription factor 1
img OMIM, Score=1000, UMLKSK CUI: C0035450
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0035450Rheumatoid Nodule0self