Genes (137)
Species: human : 130 mouse : 7 | |
Mouse | EZR | 7430 | ezrin | Subsequent in vivo functional studies revealed that the actin filament-plasma membrane linker ezrin (encoded by Vil2) and the homeodomain-containing transcription factor Six-1 (sine oculis-related homeobox-1 homolog) had essential roles in determining the metastatic fate of RMS cells. | Mouse | PAX3 | 5077 | paired box 3 | Retroviral mediated ectopic expression of mouse Pax3 in a PAX7 expressing embryonal RMS cell line could partially rescue antisense induced apoptosis. The expression levels of these genes correlate with the PAX3 expression levels in mouse embryos or with PAX3-FKHR expression levels in rhabdomyosarcoma cell lines, and indicate they may be part of the PAX3 regulatory circuitry during embryogenesis and tumor formation. PAX3-FKHR misexpressed in terminally differentiating mouse myofibers can cause rhabdomyosarcoma at a low frequency, suggesting that skeletal muscle is an ARMS tissue of origin. | Mouse | LDHA | 3939 | lactate dehydrogenase A | Results of gel electrophoresis of transplantable rat (RA-2) and murine (MC-53) rhabdomyosarcomas show that the LDH isoenzyme spectrum of tumors growing subcutaneously differ from that of normal muscle tissue, LDH-1 and LDH-2 isoenzyme being absent in zymograms. | Mouse | ITGA2 | 3673 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | Integrin VLA-2 (alpha2beta1) function in postextravasation movement of human rhabdomyosarcoma RD cells in the liver. | Mouse | IL15 | 3600 | interleukin 15 | The daily administration of IL-15 to cyclophosphamide (CY)-injected mice bearing the 76-9 rhabdomyosarcoma was shown to prolong the period of remission induced by CY. Previous studies have demonstrated that IL-15 administration after cyclophosphamide (CY) injection of C57BL/6J mice bearing the i.m. 76-9 rhabdomyosarcoma resulted in a significant prolongation of life. | Mouse | IGFBP6 | 3489 | insulin-like growth factor binding protein 6 | Overexpression of insulin-like growth factor binding protein-6 inhibits rhabdomyosarcoma growth in vivo. Low expression of IGFBP-6 may therefore contribute to rhabdomyosarcoma growth and metastasis. CCI-779 thus acts additively with IGFBP-6 to reduce rhabdomyosarcoma growth both in vitro and in vivo. IGFBP-6 therefore inhibits proliferation and promotes apoptosis of rhabdomyosarcoma in vitro and dramatically inhibits xenograft growth in vivo, at least in part by inhibiting IGF-II. | Mouse | FOXO1 | 2308 | forkhead box O1 | Activation of the transcription factor FKHR (Forkhead in human rhabdomyosarcoma, FOXO1a) in various established cell lines induces cell cycle arrest followed by apoptosis. | Human | MIR29A | 407021 | microRNA 29a | miR-29 is epigenetically silenced by an activated NF-kappaB-YY1 pathway and is associated with rhabdomyosarcoma | Human | RMST | 196475 | rhabdomyosarcoma 2 associated transcript (non-protein coding) | Identification of a novel gene NCRMS on chromosome 12q21 with differential expression between rhabdomyosarcoma subtypes. | Human | JDP2 | 122953 | Jun dimerization protein 2 | Endogenous expression of JDP2 was induced in both C2C12 myoblast and rhabdomyosarcoma (RD) cells programmed to differentiate. Induction of terminal differentiation by the c-Jun dimerization protein JDP2 in C2 myoblasts and rhabdomyosarcoma cells. | Human | SCGB3A1 | 92304 | secretoglobin, family 3A, member 1 | Promoter methylation of HIN-1 was found in 90% of retinoblastomas, 73% of Wilms; tumors, 61% of rhabdomyosarcomas, 57% of breast cancers, 52% of prostate cancers, 40% of MMs, 28% of NSCLCs and 27% of lymphomas. | Human | BOC | 91653 | BOC cell adhesion associated, oncogene regulated | The current study sought to test whether the promyogenic properties of CDO and BOC could be extended to a human rhabdomyosarcoma cell line, RD. Overexpression of the immunoglobulin superfamily members CDO and BOC enhances differentiation of the human rhabdomyosarcoma cell line RD. | Human | ANTXR1 | 84168 | anthrax toxin receptor 1 | Loss of alleles and imprinting at 11p15.5 and disruption of genes such as IGF2, ATR, PTC, P16, and TP53 have also been implicated in rhabdomyosarcoma development. | Human | FEM1A | 55527 | fem-1 homolog a (C. elegans) | Fem1a downregulation may be involved in, and/or a marker of, an early cell fate defect fundamental to rhabdomyosarcoma pathogenesis | Human | CDON | 50937 | cell adhesion associated, oncogene regulated | Overexpression of the immunoglobulin superfamily members CDO and BOC enhances differentiation of the human rhabdomyosarcoma cell line RD. The current study sought to test whether the promyogenic properties of CDO and BOC could be extended to a human rhabdomyosarcoma cell line, RD. | Human | TRPM5 | 29850 | transient receptor potential cation channel, subfamily M, member 5 | MTR1 transcripts are present in a large proportion of WTs and rhabdomyosarcomas. | Human | ANKRD2 | 26287 | ankyrin repeat domain 2 (stretch responsive muscle) | Arpp is a novel skeletal muscle-specific marker, which is useful for differential diagnosis of rhabdomyosarcoma | Human | ICOSLG | 23308 | inducible T-cell co-stimulator ligand | We also detected mRNA and cell surface protein expression of ICOSL on myoblasts cultured from control subjects and patients as well as in TE671 muscle rhabdomyosarcoma cells. | Human | COPS5 | 10987 | COP9 signalosome subunit 5 | These findings suggest that JAB1 may play an important role in determining the differentiation stage of rhabdomyosarcoma cells by modulating the activity of CDK inhibitor p27. | Human | NES | 10763 | nestin | Previous findings that the intermediate filament nestin is expressed in immature skeletal muscle cells prompted us to compare the staining patterns of nestin and desmin in rhabdomyosarcomas (RMSs) and in other small cell tumors of infancy. | Human | CHL1 | 10752 | cell adhesion molecule L1-like | In addition to rhabdomyosarcoma, a variety of other tumors, most of which have been previously shown to express neural cell adhesion molecule, also appear to express the antigen recognized by 5.1 H11. | Human | TNFSF13B | 10673 | tumor necrosis factor (ligand) superfamily, member 13b | Report bioassay for human BAFF based on expression of a mouse BAFF-receptor ectodomain-human tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor-2 endodomain fusion receptor in human rhabdomyosarcoma cells | Human | MVP | 9961 | major vault protein | The findings indicate that the in vivo expression of LRP, but not of Pgp and MRP-1, is induced by chemotherapeutic treatment in rhabdomyosarcomas. Expression of multidrug resistance-associated proteins in rhabdomyosarcomas before and after chemotherapy: the relationship between lung resistance-related protein (LRP) and differentiation. Paraffin-embedded samples of 13 pairs of primary untreated rhabdomyosarcomas and their residual, recurrent, or metastatic lesions after chemotherapy were assessed for expression of MDR proteins, including P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP-1), and lung resistance-related protein (LRP). | Human | XAGE1D | 9503 | X antigen family, member 1D | XAGE-1 and XAGE-2 are expressed in Ewing;s sarcoma, rhabdomyosarcoma, a breast cancer, and a germ cell tumor. One previously described member of the CT antigen family, XAGE-1, was shown to be expressed in Ewing;s sarcomas and rhabdomyosarcomas. | Human | XAGE2 | 9502 | X antigen family, member 2 | XAGE-1 and XAGE-2 are expressed in Ewing;s sarcoma, rhabdomyosarcoma, a breast cancer, and a germ cell tumor. XAGE-1 and XAGE-2 are expressed in Ewing;s sarcoma, rhabdomyosarcoma, a breast cancer, and a germ cell tumor. |
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