Human | MIR137 | 406928 | microRNA 137 | higher induced levels of miR125b and miR137 in rectal cancer are associated with worse response to the therapy |
Human | ENPP7 | 339221 | ectonucleotide pyrophosphatase/phosphodiesterase 7 | In sporadic rectal tumors similar alkaline sphingomyelinase activities were identified in tumors with somatic APC gene mutations as in samples without mutations. Alkaline sphingomyelinase activity was also measured in 11 human rectal tumors with APC gene mutation and compared with 9 control tumors without mutation. |
Human | GIPC2 | 54810 | GIPC PDZ domain containing family, member 2 | Expression of GIPC2 mRNA was significantly down-regulated in 6 out of 14 cases of primary kidney tumors, in 5 out of 11 cases of primary colon tumors, and in 1 out of 7 cases of primary rectal tumors. |
Human | DLC1 | 10395 | deleted in liver cancer 1 | Using cancer-profiling arrays, we detected for the first time down-regulation of DLC-1 expression in renal, uterine and rectal cancers and down-regulation of DLC-2 expression in lung, ovarian, renal, breast, uterine, gastric, colon and rectal tumors. |
Human | SCG2 | 7857 | secretogranin II | On the other hand, all rectal tumours expressed secretogranin II (7/7), frequently in the absence of chromogranin A. |
Human | VEGFA | 7422 | vascular endothelial growth factor A | VEGF assessed immunohistochemically from preirradiation tumor biopsies may be a useful marker of rectal tumor response to preoperative radiotherapy |
Human | VDR | 7421 | vitamin D (1,25- dihydroxyvitamin D3) receptor | haplotype analysis that encompasses different domains of the VDR gene might further our understanding of associations between the VDR gene and colon and rectal cancer |
Human | TP53 | 7157 | tumor protein p53 | TP53 levels were not helpful in identifying patients who would benefit from neoadjuvant treatment of rectal cancer Both survivors and nonsurvivors of fluorouracil treated rectal neoplasms show high P53 expression Co-mutation of p53 and K-ras gene has neither synergic carcinogenesis-promoting effect, nor prognostic effect on rectal cancer |
Human | TIMP1 | 7076 | TIMP metallopeptidase inhibitor 1 | Title:Association between preoperative plasma levels of t inhibitor of metalloproteinases 1 and rectal cancer patient survival. a validation study.|Association:Not Found|Conclusion:Not Found |
Human | TCF7L2 | 6934 | transcription factor 7-like 2 (T-cell specific, HMG-box) | Novel mutations in exon 4 of hTCF-4 gene were revealed in this study, which might be of importance in the pathogenesis of sporadic rectal cancer patients with high frequency microsatellite instability |
Human | CXCL12 | 6387 | chemokine (C-X-C motif) ligand 12 | G>A functional transition mapping the 3' untranslated region of the CXCL12 gene has been found to be under-represented among rectal cancer patients when compared to colon cancer patients |
Human | PDGFRB | 5159 | platelet-derived growth factor receptor, beta polypeptide | Cetuximab-based chemoradiotherapy increased PDGFRbeta levels in patients with rectal cancer |
Human | MTHFR | 4524 | methylenetetrahydrofolate reductase (NAD(P)H) | folate intake, low methyl donor status, and MTHFR polymorphisms may play independent roles in the etiology of rectal cancer MTHFR 677T-1298A haplotype in genomic DNA has the potential to be a predictive marker of tumor response in rectal cancer patients submitted to preoperative chemoradiotherapy |
Human | MKI67 | 4288 | antigen identified by monoclonal antibody Ki-67 | Ki-67 levels were not helpful in identifying patients who would benefit from neoadjuvant treatment of rectal cancer |
Human | CD46 | 4179 | CD46 molecule, complement regulatory protein | Among surface-biotinylated proteins from a human rectal tumor cell line (HRT), measles virus was able to bind only to a 67-kDa protein that was identified as MCP. |
Human | HRAS | 3265 | Harvey rat sarcoma viral oncogene homolog | k-ras may have a role in progression of rectal cancer after resection |
Human | F3 | 2152 | coagulation factor III (thromboplastin, tissue factor) | correlation between tissue factor (TF) expression and hepatic metastasis and prognosis in rectal cancer |
Human | ETV4 | 2118 | ets variant 4 | E1AF is correlated significantly with tumor progression of human rectal cancer and may be an important factor in rectal cancer progression |
Human | EGFR | 1956 | epidermal growth factor receptor | EGFR may have a role in recurrence of rectal cancer after radiotherapy and surgery Epidermal growth factor receptor gene polymorphisms have higher risk of pelvic recurrence in patients with rectal cancer treated with chemoradiation |
Human | CYP2E1 | 1571 | cytochrome P450, family 2, subfamily E, polypeptide 1 | The CYP2E1 c2/c2 genotype increases susceptibility to rectal cancer and the gene-environmental interactions between the CYP2E1 polymorphism and smoking or alcohol drinking exist for colorectal neoplasia in general |
Human | CHAT | 1103 | choline O-acetyltransferase | METHODS: Two investigators independently did a blinded immunohistochemical image analysis of localising antibodies to choline acetyltransferase, co-localised with protein gene product (PGP)--a marker of general neural tissue-and smooth muscle muscarinic M3 receptors, on three histological sections of sigmoid colons from ten patients with diverticular disease and ten controls, after resections for rectal tumours. |
Human | CEACAM5 | 1048 | carcinoembryonic antigen-related cell adhesion molecule 5 | TNM staging, preoperative CEA and CD44v6 were independent prognostic factors for rectal cancer patients with total mesorectal excision |
Human | CDH1 | 999 | cadherin 1, type 1, E-cadherin (epithelial) | E-cadherin is hypermethylated and shows low expression in colon and rectal neoplasms |
Human | CCKBR | 887 | cholecystokinin B receptor | Co-expression of gastrin and CCK2 receptor mRNA occurred in 20% colon and 9% rectal tumours. |
Human | CASP3 | 836 | caspase 3, apoptosis-related cysteine peptidase | Caspase-3 may have a role in local recurrence in rectal cancer |