Human | PTPN22 | 26191 | protein tyrosine phosphatase, non-receptor type 22 (lymphoid) | Results do not support a potential implication of the PTPN22 gene polymorphism in the susceptibility to and clinical expression of Henoch-Schonlein purpura |
Human | NPHS2 | 7827 | nephrosis 2, idiopathic, steroid-resistant (podocin) | The result did not support the possible role of the NPHS2 gene in susceptibility to Henoch-Schonlein purpura nephritis in the population studied |
Human | SCGB1A1 | 7356 | secretoglobin, family 1A, member 1 (uteroglobin) | These results do not support a role for UG in susceptibility to childhood Henoch-Schonlein purpura |
Human | SELL | 6402 | selectin L | Anaphylactoid purpura association |
Human | SELE | 6401 | selectin E | Anaphylactoid purpura association |
Human | PON1 | 5444 | paraoxonase 1 | children with active-stage Henoch-Schonlein purpura had significantly lower PON (paraoxonase ) levels than controls |
Human | PIGR | 5284 | polymeric immunoglobulin receptor | Anaphylactoid purpura association |
Human | NOS3 | 4846 | nitric oxide synthase 3 (endothelial cell) | no role for enos polymorphisms in the susceptibility to Henoch Schonlein purpura |
Human | NOS2 | 4843 | nitric oxide synthase 2, inducible | Significant differences in the NOS2A promoter polymorphism allele and genotype frequency between Henoch-Schonlein Purppura(HSP)patients and controls suggest a potential role for this gene in the susceptibility to HSP and in the development of nephritis |
Human | MMP9 | 4318 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | MMP-9 plays an important role in the vascular destruction of Henoch-Schonlein purpura, and circulating white blood cells may be a source of the MMP-9 secreted into the circulation.may be a source of the MMP-9 secreted into the circulation |
Human | MET | 4233 | met proto-oncogene | Report renal expression of alpha-smooth muscle actin and c-Met in children with Henoch-Schonlein purpura nephritis |
Human | IL6 | 3569 | interleukin 6 (interferon, beta 2) | the polymorphism in IL-6 gene promoter (-174 G/C) does not appear to be a genetic risk factor for Henoch-Schonlein pur-pura in Northwest Spain |
Human | IL1B | 3553 | interleukin 1, beta | In unselected patients with cutaneous vasculitis who fulfill classification criteria for Henoch Schonlein purpura, carriage of IL-1beta (-511) T allele appears to influence severity of renal involvement |
Human | HLA-DRB1 | 3123 | | Henoch-Schonlein purpura and cutaneous leukocytoclastic angiitis exhibit different HLA-DRB1 genotype associations that genetic factors from HLA-DRB1 (histocompatibility antigen DR-1 beta)genotypes might be related to the susceptibility to Henoch-Schonlein purpura for Turkish children but not to the severity of this disease HLA-DRB1*13 could be a risk factor for developing nephrotic-range proteinuria in Henoch Schonlein purpura patients |
Human | HLA-DQA1 | 3117 | | Title:[Correlation between HLA-DQA1 allele and anaphylactoid purpura in juvenile Hans residing in Inner Mongolia]|Association:Not Found|Conclusion:The allele of HLA-DQA1*0301 was probably a susceptible gene while HLA-DQA1*0302 was the protective one in AP of the children who were Han inhabitants in Inner Mongolia. The results of this study also revealed that patients with the allele of HLA-DQA1*0301 tended to involve gastrointestinal, joint and renal impairment. |
Human | HLA-B | 3106 | | Increased frequency of HLA A2, A11, and B35 alleles in unselected pediatric Henoch Schonlein purpura patient population may be a risk factor for susceptibility |
Human | CTLA4 | 1493 | cytotoxic T-lymphocyte-associated protein 4 | CTLA-4 +49 A/G polymorphism does not contribute to susceptibility to Henoch-Schonlein purpura; however, the presence of CTLA-4 AG genotype |
Human | CP | 1356 | ceruloplasmin (ferroxidase) | CP levels wefre determined in children with Henoch-Schonlein purpura |
Human | CAT | 847 | catalase | Significant positive correlations were found between CAT(catalase) and MDA (malondialdehyde) and between CAT and C-reactive protein in children in the active stage of Henoch-Schonlein purpura; CAT levels were lower in patients |
Human | C4B | 721 | complement component 4B (Chido blood group) | C4 null alleles were significantly more common in Henoch-Schonlein purpura patients than in controls |
Human | AGT | 183 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | Agt gene was associated with the susceptibility to Henoch-Schonlein purpura |
Human | ADM | 133 | adrenomedullin | Adrenomedullin and nitrates may have a role in immunoinflammatory process of Henoch-Schonlein purpura, especially in active stage, although whether this perpetuates, or protects against, further vascular injury is not clear |