Mouse | ARG1 | 383 | arginase 1 | By comparing the early response to silica in C57BL/6 and BALB/c mice, we observed that the amplitude of Arg-1 mRNA up-regulation was not associated with the severity of lung fibrosis. |
Human | SFTPA1 | 653509 | surfactant protein A1 | variants may serve as markers to identify subgroups of patients at risk, and may contribute to pulmonary fibrosis Title:Surfactant protein A and B genetic variants predispose to idiopathic pulmonary fibrosis|Association:Not Found|Conclusion:These findings indicate that surfactant protein variants may serve as markers to identify subgroups of patients at risk, and we speculate that these contribute to IPF pathogenesis. |
Human | HPS4 | 89781 | Hermansky-Pudlak syndrome 4 | Hermansky-Pudlak syndrome type 4 (HPS-4) patients exhibited iris transillumination, variable hair and skin pigmentation, absent platelet dense bodies, and occasional pulmonary fibrosis and granulomatous colitis |
Human | ROBO4 | 54538 | roundabout, axon guidance receptor, homolog 4 (Drosophila) | ROBO4 mRNA decreases during pulmonary fibrosis and hypertension |
Human | TINF2 | 26277 | TERF1 (TRF1)-interacting nuclear factor 2 | |
Human | HEY1 | 23462 | hairy/enhancer-of-split related with YRPW motif 1 | Declines in HEY1 are associated with pulmonary fibrosis and hypertension |
Human | SLIT2 | 9353 | slit homolog 2 (Drosophila) | SLIT2 mRNA decreases with vascular function decline in pulmonary fibrosis |
Human | AP3B1 | 8546 | adaptor-related protein complex 3, beta 1 subunit | Pulmonary fibrosis due to recurrent infections |
Human | TNF | 7124 | tumor necrosis factor | results suggest that overexpression of tumor necrosis factor (TNF)-alpha or exogenous TNF-alpha limits pulmonary fibrosis Title:Risk of chemotherapy-induced pulmonary fibrosis is associated with polymorphic tumour necrosis factor-a2 gene.|Association:Y|Conclusion:Not Found |
Human | TGFB1 | 7040 | transforming growth factor, beta 1 | Interleukin-7 and transforming growth factor-beta play counter-regulatory roles in protein kinase C-delta-dependent control of fibroblast collagen synthesis in pulmonary fibrosis TGFbeta1 polymorphisms do not play a role in the pathogenesis of systemic sclerosis, but they may be a risk factor for genetic susceptibility to pulmonary fibrosis |
Human | TERT | 7015 | telomerase reverse transcriptase | 6 new missense mutations in TERT were identified in subjects with adult-onset pulmonary fibrosis |
Human | TERC | 7012 | telomerase RNA component | |
Human | SGK1 | 6446 | serum/glucocorticoid regulated kinase 1 | Excessive transcription of the human serum and glucocorticoid dependent kinase hSGK1 in lung fibrosis |
Human | SFTPD | 6441 | surfactant protein D | Title:Surfactant protein A and B genetic variants predispose to idiopathic pulmonary fibrosis|Association:Not Found|Conclusion:These findings indicate that surfactant protein variants may serve as markers to identify subgroups of patients at risk, and we speculate that these contribute to IPF pathogenesis. |
Human | SFTPC | 6440 | surfactant protein C | Title:Surfactant protein A and B genetic variants predispose to idiopathic pulmonary fibrosis|Association:Not Found|Conclusion:These findings indicate that surfactant protein variants may serve as markers to identify subgroups of patients at risk, and we speculate that these contribute to IPF pathogenesis. |
Human | SFTPB | 6439 | surfactant protein B | Title:Surfactant protein A and B genetic variants predispose to idiopathic pulmonary fibrosis|Association:Not Found|Conclusion:These findings indicate that surfactant protein variants may serve as markers to identify subgroups of patients at risk, and we speculate that these contribute to IPF pathogenesis. |
Human | SFTPA2B | 6436 | | Title:Surfactant protein A and B genetic variants predispose to idiopathic pulmonary fibrosis|Association:Not Found|Conclusion:These findings indicate that surfactant protein variants may serve as markers to identify subgroups of patients at risk, and we speculate that these contribute to IPF pathogenesis. |
Human | CXCL12 | 6387 | chemokine (C-X-C motif) ligand 12 | Taken together, these data suggest that fibrocytes are involved in the pathogenesis of human lung fibrosis |
Human | CCL18 | 6362 | chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) | These findings suggest that CCL18 production by bronchoalveolar lavage cells and serum CCL18 concentrations reflect pulmonary fibrotic activity in patients with idiopathic interstitial pneumonias and those with systemic sclerosis |
Human | CCL11 | 6356 | chemokine (C-C motif) ligand 11 | A significant correlation exists between bronchoalveolar lavage concentration of CCL11 and eosinophils in veterans with sulfur mustard gas-induced pulmonary fibrosis |
Human | CCL5 | 6352 | chemokine (C-C motif) ligand 5 | A significant correlation exists between bronchoalveolar lavage concentration of CCL5 and eosinophils in veterans with sulfur mustard gas-induced pulmonary fibrosis |
Human | CCL2 | 6347 | chemokine (C-C motif) ligand 2 | M-CSF contributes to the pathogenesis of pulmonary fibrosis in mice and in patients with IPF through the involvement of mononuclear phagocytes and CCL2 production |
Human | SERPINB3 | 6317 | serpin peptidase inhibitor, clade B (ovalbumin), member 3 | Squamous cellular carcinoma immunocomplexed is increased in scleroderma patients with lung fibrosis |
Human | PRKCD | 5580 | protein kinase C, delta | Interleukin-7 and transforming growth factor-beta play counter-regulatory roles in protein kinase C-delta-dependent control of fibroblast collagen synthesis in pulmonary fibrosis |
Human | PPARG | 5468 | peroxisome proliferator-activated receptor gamma | PPARgamma plays an important role in controlling cell differentiation and PPARgamma ligands can modify inflammatory and fibrotic responses in pulmonary fibrosis |