Mouse | ARG1 | 383 | arginase 1 | By comparing the early response to silica in C57BL/6 and BALB/c mice, we observed that the amplitude of Arg-1 mRNA up-regulation was not associated with the severity of lung fibrosis. |
Human | SFTPA1 | 653509 | surfactant protein A1 | Title:Surfactant protein A and B genetic variants predispose to idiopathic pulmonary fibrosis|Association:Not Found|Conclusion:These findings indicate that surfactant protein variants may serve as markers to identify subgroups of patients at risk, and we speculate that these contribute to IPF pathogenesis. variants may serve as markers to identify subgroups of patients at risk, and may contribute to pulmonary fibrosis |
Human | HPS4 | 89781 | Hermansky-Pudlak syndrome 4 | Hermansky-Pudlak syndrome type 4 (HPS-4) patients exhibited iris transillumination, variable hair and skin pigmentation, absent platelet dense bodies, and occasional pulmonary fibrosis and granulomatous colitis |
Human | ROBO4 | 54538 | roundabout, axon guidance receptor, homolog 4 (Drosophila) | ROBO4 mRNA decreases during pulmonary fibrosis and hypertension |
Human | TINF2 | 26277 | TERF1 (TRF1)-interacting nuclear factor 2 | |
Human | HEY1 | 23462 | hairy/enhancer-of-split related with YRPW motif 1 | Declines in HEY1 are associated with pulmonary fibrosis and hypertension |
Human | SLIT2 | 9353 | slit homolog 2 (Drosophila) | SLIT2 mRNA decreases with vascular function decline in pulmonary fibrosis |
Human | AP3B1 | 8546 | adaptor-related protein complex 3, beta 1 subunit | Pulmonary fibrosis due to recurrent infections |
Human | TNF | 7124 | tumor necrosis factor | Title:Risk of chemotherapy-induced pulmonary fibrosis is associated with polymorphic tumour necrosis factor-a2 gene.|Association:Y|Conclusion:Not Found results suggest that overexpression of tumor necrosis factor (TNF)-alpha or exogenous TNF-alpha limits pulmonary fibrosis |
Human | TGFB1 | 7040 | transforming growth factor, beta 1 | Interleukin-7 and transforming growth factor-beta play counter-regulatory roles in protein kinase C-delta-dependent control of fibroblast collagen synthesis in pulmonary fibrosis TGFbeta1 polymorphisms do not play a role in the pathogenesis of systemic sclerosis, but they may be a risk factor for genetic susceptibility to pulmonary fibrosis |
Human | TERT | 7015 | telomerase reverse transcriptase | 6 new missense mutations in TERT were identified in subjects with adult-onset pulmonary fibrosis |
Human | TERC | 7012 | telomerase RNA component | |
Human | SGK1 | 6446 | serum/glucocorticoid regulated kinase 1 | Excessive transcription of the human serum and glucocorticoid dependent kinase hSGK1 in lung fibrosis |
Human | SFTPD | 6441 | surfactant protein D | Title:Surfactant protein A and B genetic variants predispose to idiopathic pulmonary fibrosis|Association:Not Found|Conclusion:These findings indicate that surfactant protein variants may serve as markers to identify subgroups of patients at risk, and we speculate that these contribute to IPF pathogenesis. |
Human | SFTPC | 6440 | surfactant protein C | Title:Surfactant protein A and B genetic variants predispose to idiopathic pulmonary fibrosis|Association:Not Found|Conclusion:These findings indicate that surfactant protein variants may serve as markers to identify subgroups of patients at risk, and we speculate that these contribute to IPF pathogenesis. |
Human | SFTPB | 6439 | surfactant protein B | Title:Surfactant protein A and B genetic variants predispose to idiopathic pulmonary fibrosis|Association:Not Found|Conclusion:These findings indicate that surfactant protein variants may serve as markers to identify subgroups of patients at risk, and we speculate that these contribute to IPF pathogenesis. |
Human | SFTPA2B | 6436 | | Title:Surfactant protein A and B genetic variants predispose to idiopathic pulmonary fibrosis|Association:Not Found|Conclusion:These findings indicate that surfactant protein variants may serve as markers to identify subgroups of patients at risk, and we speculate that these contribute to IPF pathogenesis. |
Human | CXCL12 | 6387 | chemokine (C-X-C motif) ligand 12 | Taken together, these data suggest that fibrocytes are involved in the pathogenesis of human lung fibrosis |
Human | CCL18 | 6362 | chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) | These findings suggest that CCL18 production by bronchoalveolar lavage cells and serum CCL18 concentrations reflect pulmonary fibrotic activity in patients with idiopathic interstitial pneumonias and those with systemic sclerosis |
Human | CCL11 | 6356 | chemokine (C-C motif) ligand 11 | A significant correlation exists between bronchoalveolar lavage concentration of CCL11 and eosinophils in veterans with sulfur mustard gas-induced pulmonary fibrosis |
Human | CCL5 | 6352 | chemokine (C-C motif) ligand 5 | A significant correlation exists between bronchoalveolar lavage concentration of CCL5 and eosinophils in veterans with sulfur mustard gas-induced pulmonary fibrosis |
Human | CCL2 | 6347 | chemokine (C-C motif) ligand 2 | M-CSF contributes to the pathogenesis of pulmonary fibrosis in mice and in patients with IPF through the involvement of mononuclear phagocytes and CCL2 production |
Human | SERPINB3 | 6317 | serpin peptidase inhibitor, clade B (ovalbumin), member 3 | Squamous cellular carcinoma immunocomplexed is increased in scleroderma patients with lung fibrosis |
Human | PRKCD | 5580 | protein kinase C, delta | Interleukin-7 and transforming growth factor-beta play counter-regulatory roles in protein kinase C-delta-dependent control of fibroblast collagen synthesis in pulmonary fibrosis |
Human | PPARG | 5468 | peroxisome proliferator-activated receptor gamma | PPARgamma plays an important role in controlling cell differentiation and PPARgamma ligands can modify inflammatory and fibrotic responses in pulmonary fibrosis |