Human | EFEMP2 | 30008 | EGF containing fibulin-like extracellular matrix protein 2 | |
Human | FBLN5 | 10516 | fibulin 5 | |
Human | C5orf13 | 9315 | | P311 expression is tightly regulated during the critical periods of alveolar formation, and that under pathologic conditions, its relative absence may contribute to failure of alveolar regeneration and lead to the development of human emphysema |
Human | TNFRSF10A | 8797 | tumor necrosis factor receptor superfamily, member 10a | TRAILR1 (TNF-related apoptosis inducing ligand receptor 1) levels were significantly higher in lung parenchyma in subjects with emphysema |
Human | TNFRSF10B | 8795 | tumor necrosis factor receptor superfamily, member 10b | TRAILR2 (TNF-related apoptosis inducing ligand receptor 2) levels were significantly higher in lung parenchyma in subjects with emphysema |
Human | TNFRSF10C | 8794 | tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain | TRAILR3 (TNF-related apoptosis inducing ligand receptor 3) levels were significantly higher in lung parenchyma in subjects with emphysema |
Human | TP53 | 7157 | tumor protein p53 | p53 levels were significantly higher in lung parenchyma in subjects with emphysema |
Human | TNF | 7124 | tumor necrosis factor | Title:Tumour necrosis factor family genes in a phenotype of COPD associated with emphysema.|Association:Y|Conclusion:No significant deviations were found concerning the four polymorphisms studied between the two populations. The authors confirm that the tumour necrosis factor family genes, at least for the polymorphisms investigated, are not major genetic risk factors for chronic obstructive pulmonary disease in Caucasians, either defined in terms of emphysema (this study) or airflow obstruction (previous studies). Nevertheless, the authors would like to emphasise the importance of narrowing the phenotype in the search for genetic risk factors in chronic obstructive pulmonary disease. |
Human | TAPBP | 6892 | TAP binding protein (tapasin) | |
Human | TAP2 | 6891 | transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) | |
Human | TAP1 | 6890 | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | |
Human | CCL5 | 6352 | chemokine (C-C motif) ligand 5 | CC chemokine ligand 5 gene may be part of a common pathway in the pathogenesis of late-onset asthma and chronic obstructive pulmonary disease with milder emphysema |
Human | RAP1A | 5906 | RAP1A, member of RAS oncogene family | The patients with emphysema had significantly higher percentages of type II cells positive for p16INK4a and p21CIP1/WAF1/Sdi1 than the asymptomatic smokers and nonsmokers |
Human | PTGS2 | 5743 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Decreased PGI2S protein and mRNA in the lungs from patients with emphysema |
Human | SERPINA1 | 5265 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | polymeric alpha(1)-anti-trypsin co-localizes with neutrophils in the alveoli of individuals with Z alpha(1)-antitrypsin-related emphysema |
Human | MMP14 | 4323 | matrix metallopeptidase 14 (membrane-inserted) | The identification that induction of MMP-2 and MT1-MMP by CSE from lung fibroblasts is EGR-1-dependent reveals a molecular mechanism for matrix remodeling in cigarette smoke-related emphysema |
Human | MMP12 | 4321 | matrix metallopeptidase 12 (macrophage elastase) | Alveolar macrophage matrix metalloproteinase 1 and 12 may have a role in the lung structural changes leading to the development of emphysema |
Human | MMP9 | 4318 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | Polymorphism of MMP-9 (C-1562T) was associated with upper lung dominant emphysema in patients with COPD Title:Genetic polymorphism in matrix metalloproteinase-9 and pulmonary emphysema|Association:Y|Conclusion:These results suggest that the polymorphism of MMP-9 acts as a genetic factor for the development of smoking-induced pulmonary emphysema. Genetic polymorphism in MMP9 may have a pathogenic effect in human pulmonary emphysema |
Human | MMP1 | 4312 | matrix metallopeptidase 1 (interstitial collagenase) | MMP1 plays a pathogenic role in human emphysema MMP-1 induces progressive adult-onset emphysema by the selective degradation of type III collagen within the alveolar wall |
Human | MET | 4233 | met proto-oncogene | expression of hepatocyte and keratinocyte growth factors and their receptors is preserved in patients with lung emphysema as compared to patients without emphysema |
Human | LOX | 4015 | lysyl oxidase | |
Human | ITGB6 | 3694 | integrin, beta 6 | Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema |
Human | IFNG | 3458 | interferon, gamma | Transgenic interferon-gamma induces alveolar epithelial cell DNA injury and apoptosis via a novel murine cathepsin S-dependent pathway, a critical event in the pathogenesis of alveolar remodeling, emphysema and inflammation |
Human | HMOX1 | 3162 | heme oxygenase (decycling) 1 | Title:Genetic susceptibility for emphysematous changes of the lung in Japanese|Association:Y|Conclusion:These findings suggest that combination of several polymorphisms in the enzymes that activate or detoxify the tobacco smoke, such as EPHX1 and HMOX1, might be associated with its affects on the development of emphysematous changes of the lung. Title:|Association:Y|Conclusion:Not Found |
Human | HGF | 3082 | hepatocyte growth factor (hepapoietin A; scatter factor) | expression of hepatocyte and keratinocyte growth factors and their receptors is preserved in patients with lung emphysema as compared to patients without emphysema; hepatocyte growth factor mRNA correlates with severity of airflow obstruction in smokers |