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Genes (15)
Species: human : 15 | |
Human | LACRT | 90070 | lacritin | Lacritin is detected in human tears by mass spectometry from patients with pterygium | Human | VEGFA | 7422 | vascular endothelial growth factor A | These results indicate that TGF-Beta1-509 and VEGF-460 polymorphisms were not highly associated with the pathology of pterygium Pterygia exhibit significantly lower PEDF but higher VEGF levels than those in normal corneas and conjunctivae | Human | TPSAB1 | 7177 | tryptase alpha/beta 1 | These results suggest that the characteristic neovascularization observed in pterygium may be sustained, at least in part, by mast cells angiogenic mediators, in particular tryptase | Human | TP53 | 7157 | tumor protein p53 | Although pterygium has limited local invasion and ainability to metastasize, concomitant presence of altered p53 in 8-OHdG-immunoreactive cells could provide evidence of apparent genetic instability, which is in contrast to its benign clinical course relation with p53 protein expression, p53 gene codon 72 polymorphism and infection with HPV DNA with pterygium BPDE-like DNA adducts are indeed detected in pterygium samples, and they are only minor contributors to the abnormal p53 gene | Human | TFF3 | 7033 | trefoil factor 3 (intestinal) | TFF1, TFF2, TFF3 and MUC5AC may have roles in pathogenesis of pterygium goblet cells | Human | TFF2 | 7032 | trefoil factor 2 | TFF1, TFF2, TFF3 and MUC5AC may have roles in pathogenesis of pterygium goblet cells | Human | TFF1 | 7031 | trefoil factor 1 | TFF1, TFF2, TFF3 and MUC5AC may have roles in pathogenesis of pterygium goblet cells | Human | PLOD2 | 5352 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | a boy who had congenital contractures with pterygia at birth and severe OI-like osteopenia and multiple fractures and he was shown to be homozygous for a novel mutation leading to an Arg598His substitution in PLOD2 | Human | MUC5AC | 4586 | mucin 5AC, oligomeric mucus/gel-forming | TFF1, TFF2, TFF3 and MUC5AC may have roles in pathogenesis of pterygium goblet cells | Human | ICAM1 | 3383 | intercellular adhesion molecule 1 | Pterygium epithelium also seems to participate actively in the augmentation of this inflammatory process by expressing ICAM-1 and HLA-DR molecules | Human | GSTM1 | 2944 | glutathione S-transferase mu 1 | These results indicate GSTM1 null genotype is associated with early onset pterygium, but not associated with late onset pterygium | Human | XRCC6 | 2547 | X-ray repair complementing defective repair in Chinese hamster cells 6 | The Ku70 promoter T-991C, but not the Ku70 promoter C-57G polymorphism, is correlated with pterygium | Human | EPOR | 2057 | erythropoietin receptor | These results suggest that the erythropoietin-independent EpoR-signaling pathway plays a potential role in cell proliferation and angiogenesis in human pterygium | Human | DNMT3B | 1789 | DNA (cytosine-5-)-methyltransferase 3 beta | The p16 gene promoter was hypermethylated in pterygia, and this hypermethylation was strongly linked to expression of the positive expression of DNMT3b protein and to the suppression of p16 protein | Human | CHRNG | 1146 | cholinergic receptor, nicotinic, gamma (muscle) | Pterygia of digits, neck, axillae, antecubital, popliteal, intercrural areas |
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