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Details
Link-It Detail - Disease - Psoriasis
Debug Stats
  • ### Total Build Time: 203 ms 55.488 KB
  • CONCEPT_NAME gt=11 ms Completed: 11 ms rowSize= 316 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 1.075 KB
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 188 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=5 ms Completed: 5 ms rowSize= 565 bytes
  • CONCEPT_CHILDREN gt=3 ms Completed: 3 ms rowSize= 558 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 1.524 KB
  • CONCEPT_RELATIONSHIPS gt=163 ms Completed: 163 ms rowSize= 15.305 KB
  • CONCEPT_GENES gt=21 ms Completed: 21 ms rowSize= 34.824 KB
  • CONCEPT_XREFS gt=0 Completed: 0 ms rowSize= 1.144 KB
  • CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Psoriasis C0033860
Definition (1)

Psoriasis is a skin disease that causes itchy or sore patches of thick, red skin with silvery scales. You usually get them on your elbows, knees, scalp, back, face, palms and feet, but they can show up on other parts of your body. A problem with your immune system causes psoriasis. In a process called cell turnover, skin cells that grow deep in your skin rise to the surface. Normally, this takes a month. In psoriasis, it happens in just days because your cells rise too fast.

Psoriasis can last a long time, even a lifetime. Symptoms come and go. Things that make them worse include

  • Infections
  • Stress
  • Dry skin
  • Certain medicines

Psoriasis usually occurs in adults. It sometimes runs in families. Treatments include creams, medications and light therapy.

NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

Semantic Types (1)
Disease or Syndrome (T047)
Parents (1)
img Skin Diseases, Papulosquamous C0162818
Children (1)
img Arthritis, Psoriatic C0003872
Ancestral Roots
RootRoot Plus OneDepthParent
img Skin and Connective Tissue Diseases C0175166img Skin Diseases C00372744img Skin Diseases, Papulosquamous C0162818
Relationships (446)

Relation Types:
diso_​to_​anat : 19
diso_​to_​chem : 318
diso_​to_​diso : 87
diso_​to_​gene : 10
diso_​to_​phen : 3
diso_​to_​phys : 9


Relationships:
none : 138
gene_​associated_​with_​disease : 8
gene_​product_​malfunction_​associated_​with_​disease : 2
is_​associated_​anatomic_​site_​of : 1
is_​finding_​of_​disease : 1
is_​primary_​anatomic_​site_​of_​disease : 1
isa : 41
mapped_​to : 4
may_​treat : 249
related_​to : 1
Page Size
Current 25
  Page 1 of 18
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_DISO559img Complication Aspects C1171258
DISO_to_CHEM545img Antibodies, Monoclonal C0003250
DISO_to_CHEM470img AGENT DERMATOL C0011625
DISO_to_PHEN449img genetic aspects C0017399
DISO_to_CHEM333img AGENT DERMATOL C0011625
DISO_to_PHEN304img genetic aspects C0017399
DISO_to_CHEM269img Immunoglobulin G C0020852
DISO_to_DISO251img Complication Aspects C1171258
DISO_to_CHEM227img Tumor Necrosis Factor-alpha C1456820
DISO_to_CHEM214img Immunosuppressive Agents C0021081
DISO_to_CHEM211img Antibodies, Monoclonal C0003250
DISO_to_CHEM209img Anti-Inflammatory Agents C0003209
DISO_to_ANAT202img Skin C1123023
DISO_to_ANAT201img In Blood C0005768
DISO_to_CHEM200img Receptors, Tumor Necrosis Factor C0077503
DISO_to_DISO171img chemically induced C0007994
DISO_to_CHEM147img Immunosuppressive Agents C0021081
DISO_to_DISO143img ARTHRITIS, PSORIATIC C0003872
DISO_to_ANAT118img Skin C1123023
DISO_to_ANAT116img Keratinocytes C0022567
DISO_to_CHEM115img Calcitriol C0006674
DISO_to_CHEM113img Methotrexate C0025677
DISO_to_ANAT111img In Blood C0005768
DISO_to_CHEM101img Fusion Proteins, Recombinant C0034857
DISO_to_DISO99img Dermatitis, Atopic C0011615
Genes (136)

Species:
human : 136
Page Size
Current 25
  Page 1 of 6
Prior Page
Current 1
SpeciesGeneGeneIdGene NameEvidence
HumanLOC100507436100507436
img GAD, Score=1000, Pubmed Id: 12653732, UMLKSK CUI: C0033860
HumanKIR2DS2100132285killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2
INFERRED, Score=800, UMLKSK CUI: C0033860
HumanPSORS1C3100130889psoriasis susceptibility 1 candidate 3 (non-protein coding)
img GAD, Score=1000, Pubmed Id: 15848982, UMLKSK CUI: C0033860
HumanMIR203406986microRNA 203
img GENERIF, Score=1000, Pubmed Id: 17622355, UMLKSK CUI: C0033860
HumanSUMO4387082small ubiquitin-like modifier 4
img GENERIF, Score=1000, Pubmed Id: 18330586, UMLKSK CUI: C0033860
HumanPSORS9359825psoriasis susceptibility 9
img OMIM, Score=1000, UMLKSK CUI: C0033860
img OMIM, Score=1000, UMLKSK CUI: C0033860
HumanLCE3C353144late cornified envelope 3C
img GENERIF, Score=1000, Pubmed Id: 19169253, UMLKSK CUI: C0033860
HumanSDR16C5195814short chain dehydrogenase/reductase family 16C, member 5
img GENERIF, Score=1000, Pubmed Id: 12372410, UMLKSK CUI: C0033860
HumanNEWENTRY192343Record to support submission of GeneRIFs for a gene not in Gene (human; man).
INFERRED, Score=800, UMLKSK CUI: C0033860
HumanPSORS1C2170680psoriasis susceptibility 1 candidate 2
img GENERIF, Score=1000, Pubmed Id: 15523160, UMLKSK CUI: C0033860
img GENERIF, Score=1000, Pubmed Id: 12930300, UMLKSK CUI: C0033860
HumanPSORS1C1170679psoriasis susceptibility 1 candidate 1
img GAD, Score=1000, Pubmed Id: 16029332, UMLKSK CUI: C0033860
HumanIL23R149233interleukin 23 receptor
Click here to display 11 evidence detail records.
HumanLRIG3121227leucine-rich repeats and immunoglobulin-like domains 3
img GENERIF, Score=1000, Pubmed Id: 18037903, UMLKSK CUI: C0033860
HumanPGLYRP3114771peptidoglycan recognition protein 3
img GENERIF, Score=1000, Pubmed Id: 16362825, UMLKSK CUI: C0033860
HumanZNF75079755zinc finger protein 750
img GENERIF, Score=694, Pubmed Id: 18256691, UMLKSK CUI: C0033860
HumanPSORS765245psoriasis susceptibility 7
img OMIM, Score=1000, UMLKSK CUI: C0033860
img OMIM, Score=1000, UMLKSK CUI: C0033860
HumanNOD264127nucleotide-binding oligomerization domain containing 2
img GENERIF, Score=1000, Pubmed Id: 12930309, UMLKSK CUI: C0033860
img GENERIF, Score=1000, Pubmed Id: 12459523, UMLKSK CUI: C0033860
HumanPSORS563870psoriasis susceptibility 5
img OMIM, Score=1000, UMLKSK CUI: C0033860
img OMIM, Score=1000, UMLKSK CUI: C0033860
HumanPSORS663869psoriasis susceptibility 6
img OMIM, Score=1000, UMLKSK CUI: C0033860
img OMIM, Score=1000, UMLKSK CUI: C0033860
HumanKIR2DL5A57292killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
img GAD, Score=1000, Pubmed Id: 15140215, UMLKSK CUI: C0033860
HumanPGLYRP457115peptidoglycan recognition protein 4
img GENERIF, Score=1000, Pubmed Id: 16362825, UMLKSK CUI: C0033860
HumanCCHCR154535coiled-coil alpha-helical rod protein 1
img GENERIF, Score=1000, Pubmed Id: 17221218, UMLKSK CUI: C0033860
img GAD, Score=1000, Pubmed Id: 15214895, UMLKSK CUI: C0033860
img GAD, Score=1000, Pubmed Id: 15654960, UMLKSK CUI: C0033860
img GENERIF, Score=1000, Pubmed Id: 17340018, UMLKSK CUI: C0033860
HumanIL20RB53833interleukin 20 receptor beta
img GENERIF, Score=1000, Pubmed Id: 18480827, UMLKSK CUI: C0033860
HumanIL20RA53832interleukin 20 receptor, alpha
img GENERIF, Score=1000, Pubmed Id: 18480827, UMLKSK CUI: C0033860
HumanIL23A51561interleukin 23, alpha subunit p19
img GENERIF, Score=1000, Pubmed Id: 14707118, UMLKSK CUI: C0033860
img GENERIF, Score=1000, Pubmed Id: 18408745, UMLKSK CUI: C0033860
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0033860Psoriasis0self