Human | LOC100507436 | 100507436 | | Title:A study of candidate genes for psoriasis near HLA-C in Chinese patients with psoriasis.|Association:Not Found|Conclusion:HLA-Cw6 remains the most significant susceptibility gene in Chinese patients with psoriasis. However, the role of the CDSN gene in the pathogenesis of psoriasis deserves further scrutiny. |
Human | KIR2DS2 | 100132285 | killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2 | INFERRED, Score=800, UMLKSK CUI: C0033860 |
Human | PSORS1C3 | 100130889 | psoriasis susceptibility 1 candidate 3 (non-protein coding) | Title:|Association:Not Found|Conclusion:Not Found |
Human | MIR203 | 406986 | microRNA 203 | Data suggest that miR-203, a keratinocyte-specific miRNA that is specifically upregulated in psoriasis, plays a specific role in the pathogenesis of psoriasis by regulating inflammation-, proliferation- and morphogenesis-associated processes in the skin |
Human | SUMO4 | 387082 | small ubiquitin-like modifier 4 | no associations of the SUMO4 rs237025 A>G polymorphism with the susceptibility of psoriasis were detected |
Human | PSORS9 | 359825 | psoriasis susceptibility 9 | HLA antigens CW6, B13, B17 associated with psoriasis Types of psoriasis include - plaque, guttate, erythrodermic, pustular |
Human | LCE3C | 353144 | late cornified envelope 3C | LCE3C_LCE3B-del shows epistatic effects with the HLA-Cw6 allele on the development of psoriasis |
Human | SDR16C5 | 195814 | short chain dehydrogenase/reductase family 16C, member 5 | mapped to chromosome 8; may be involved in the pathogenesis of psoriasis through its critical role in retinol metabolism in keratinocyte proliferation |
Human | NEWENTRY | 192343 | Record to support submission of GeneRIFs for a gene not in Gene (human; man). | INFERRED, Score=800, UMLKSK CUI: C0033860 |
Human | PSORS1C2 | 170680 | psoriasis susceptibility 1 candidate 2 | HLA-Cw*06 allele frequency is associated with psoriasis In a case-control study, five of the nine single nucleotide polymorphisms (SNPs) found in SEEK1 were associated with psoriasis, while one of the four SNPs found in SPR1 showed association |
Human | PSORS1C1 | 170679 | psoriasis susceptibility 1 candidate 1 | Title:A study of PSORS1C1 gene polymorphisms in Chinese patients with psoriasis.|Association:Not Found|Conclusion:Our results indicate that the PSORS1C1 gene might not play an important role in the causation of chronic plaque psoriasis in Chinese people. |
Human | IL23R | 149233 | interleukin 23 receptor | Click here to display 11 evidence detail records. |
Human | LRIG3 | 121227 | leucine-rich repeats and immunoglobulin-like domains 3 | LRIG proteins may have a role in epidermal homeostasis and psoriasis |
Human | PGLYRP3 | 114771 | peptidoglycan recognition protein 3 | Data are consistent with previous reports of association of psoriasis with genes on 1q21, and suggest a role for Pglyrp3 in skin biology |
Human | ZNF750 | 79755 | zinc finger protein 750 | ZNF750 mutations could contribute to psoriasis susceptibility |
Human | PSORS7 | 65245 | psoriasis susceptibility 7 | Types of psoriasis include - plaque, guttate, erythrodermic, pustular HLA antigens CW6, B13, B17 associated with psoriasis |
Human | NOD2 | 64127 | nucleotide-binding oligomerization domain containing 2 | a particular insertion mutation in the NOD2 gene does not appear to contribute to the genetic susceptibility of psoriasis in Crohn's disease There is not a strong genetic association between CARD15 gene polymorphisms and psoriasis in the Italian population |
Human | PSORS5 | 63870 | psoriasis susceptibility 5 | Types of psoriasis include - plaque, guttate, erythrodermic, pustular HLA antigens CW6, B13, B17 associated with psoriasis |
Human | PSORS6 | 63869 | psoriasis susceptibility 6 | HLA antigens CW6, B13, B17 associated with psoriasis Types of psoriasis include - plaque, guttate, erythrodermic, pustular |
Human | KIR2DL5A | 57292 | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A | Title:Genetic polymorphisms of killer cell immunoglobulin-like receptors are associated with susceptibility to psoriasis vulgaris.|Association:Not Found|Conclusion:The increase in KIR2DS1 has also been observed in psoriatic arthritis, another HLA-Cw6-associated disease (Martin et al, 2002). Accordingly, KIR2DS1 may be a common denominator of both diseases. |
Human | PGLYRP4 | 57115 | peptidoglycan recognition protein 4 | Data are consistent with previous reports of association of psoriasis with genes on 1q21, and suggest a role for Pglyrp4 in skin biology |
Human | CCHCR1 | 54535 | coiled-coil alpha-helical rod protein 1 | These results suggest a role for CCHCR1 in the pathogenesis of psoriasis via the regulation of skin steroid metabolism Title:Genetic polymorphisms of the HCR gene and a genomic segment in close proximity to HLA-C are associated with patients with psoriasis in Taiwan.|Association:Y|Conclusion:Our results indicate that the HCR gene, SNP n.7*A, and SNP n.9*C as well as Cw*0602 are major susceptibility markers for psoriasis in Chinese patients. Title:The Major Psoriasis Susceptibility Locus PSORS1 Is not a Risk Factor for Late-Onset Psoriasis|Association:Not Found|Conclusion:These data suggest that the exclusion of LOP subjects from case-control studies will aid further delineation of the PSORS1 locus. Future genome-wide studies will be required to identify loci conferring risk for late-onset disease. Results show that HLA-Cw6 and CCHCR1 risk allele associations with clinical features of psoriasis are predictably highly similar in a Finnish nationwide cohort of 379 psoriasis patients |
Human | IL20RB | 53833 | interleukin 20 receptor beta | The hypotheses that genetic variations of the IL-20-RI influence susceptibility to psoriasis and single nucleotide polymorphisms (SNPs) in the IL20RA and IL20RB genes in psoriasis patients were investigated |
Human | IL20RA | 53832 | interleukin 20 receptor, alpha | The hypotheses that genetic variations of the IL-20-RI influence susceptibility to psoriasis was investigated |
Human | IL23A | 51561 | interleukin 23, alpha subunit p19 | IL-23 plays a more dominant role than IL-12 in psoriasis, a Th1 type of human inflammatory disease IL-23 stimulates survival and proliferation of Th17 cells and thus serves as a key master cytokine regulator for psoriasis |