GATACA

Credits

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Data

Data - ToppGene Sources

The vast majority of all data in Gataca is from ToppGene so its credits cover data sources that are used within Gataca. The primary reason for utilizing the same sources between these applications is to help ensure consistancy between them. ToppGene, and Gataca, uses data from over 20 sources.

For ToppGene Credits, please visit:

ToppGene Links (Credits)

Data - GUDMAP

GUDMAP

The GUDMAP data within Gataca is only availble within the GUDMAP interface:

Gataca's GUDMAP

Data - UMLSKS

UMLSKS website

Software

Software - Solr

Solr website

Software - PrototypeJS

Prototype JS website

Prototype JavaScript framework, version 1.7
(c) 2005-2010 Sam Stephenson
 
Prototype is freely distributable under the terms of an MIT-style license.
For details, see the Prototype web site: http://www.prototypejs.org/

Software - script.aculo.us

Script.aculo.us website

NOTE: Only the effects.js and dragdrop.js modules from Script.aculo.us are being used.

// script.aculo.us scriptaculous.js v1.9.0, Thu Dec 23 16:54:48 -0500 2010

// Copyright (c) 2005-2010 Thomas Fuchs (http://script.aculo.us, http://mir.aculo.us)
//
// Permission is hereby granted, free of charge, to any person obtaining
// a copy of this software and associated documentation files (the
// "Software"), to deal in the Software without restriction, including
// without limitation the rights to use, copy, modify, merge, publish,
// distribute, sublicense, and/or sell copies of the Software, and to
// permit persons to whom the Software is furnished to do so, subject to
// the following conditions:
//
// The above copyright notice and this permission notice shall be
// included in all copies or substantial portions of the Software.
//
// THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND,
// EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF
// MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND
// NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS BE
// LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION
// OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN CONNECTION
// WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE SOFTWARE.
//
// For details, see the script.aculo.us web site: http://script.aculo.us/

Software - canvasXpress

canvasXpress website

CanvasXpress is a javascript library based on the <canvas> tag implemented in HTML5.

This package is currently being used for the Venn Diagram within SetBuilder. Plans are to utilize it in other areas in the generation of other graphs.

Software - Oracle Enterprise Edition

Oracle website

The data within Gataca is being stored in an Oracle 11g database.

Software - Modernizr

modernizr

modernizr provides simple interfacing to check to see what features are available within the client's browser. This is predomantly used to test for HTML 5 features such as canvas or local storage support.

Software - JQTouch

JQTouch website

JQTouch is being used for the mobile edition of Gataca.

Software - jQuery

JQuery website

jQuery is used within JQTouch only.

Software - tablesort

tablesort website

Copyright (c) 2006 Andrew Tetlaw 
http://tetlaw.id.au/view/blog/table-sorting-with-prototype/

Permission is hereby granted, free of charge, to any person
obtaining a copy of this software and associated documentation
files (the "Software"), to deal in the Software without
restriction, including without limitation the rights to use, copy,
modify, merge, publish, distribute, sublicense, and/or sell copies
of the Software, and to permit persons to whom the Software is
furnished to do so, subject to the following conditions:

The above copyright notice and this permission notice shall be
included in all copies or substantial portions of the Software.

Software - Firebug Light

Firebug Light website

firebugx.js - There is no disclaimer in the original file, but it is an open source project. The main website is http://www.getfirebug.com It is an open source project hosted by Google code.

Link-It Detail - Disease - Pruritus

Debug Stats

### Total Build Time: 244 ms 48.456 KB
CONCEPT_NAME gt=17 ms Completed: 17 ms rowSize= 314 bytes
CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 250 bytes
Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 184 bytes
Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
CONCEPT_PARENTS gt=4 ms Completed: 4 ms rowSize= 986 bytes
CONCEPT_CHILDREN gt=2 ms Completed: 2 ms rowSize= 1.380 KB
CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 2.802 KB
CONCEPT_RELATIONSHIPS gt=207 ms Completed: 207 ms rowSize= 15.193 KB
CONCEPT_GENES gt=13 ms Completed: 13 ms rowSize= 26.218 KB
CONCEPT_XREFS gt=1 ms Completed: 1 ms rowSize= 1.143 KB
CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
Reload Stats

Disease (1)

Pruritus C0033774

Definition (1)

An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.

Semantic Types (1)

Sign or Symptom (T184)

Parents (2)

C0037274

C0037285

Children (3)

C0033775

C0033778

C0040259

Ancestral Roots

Root	Root Plus One	Depth	Parent
Skin and Connective Tissue Diseases C0175166	Skin Diseases C0037274	3	Skin Diseases C0037274
Pathological Conditions, Signs and Symptoms C0039058	Signs and Symptoms C0037088	4	Skin Manifestations C0037285

Relationships (351)

Relation Types:

diso_to_anat : 10

diso_to_chem : 176

diso_to_diso : 163

diso_to_phen : 2

Relationships:

none : 81

associated_with : 23

classifies : 1

disease_may_have_finding : 74

is_associated_anatomic_site_of : 1

is_finding_of_disease : 1

isa : 16

location_of : 1

mapped_to : 9

may_prevent : 2

may_treat : 140

parent_is_cdrh : 1

related_to : 1

Page Size

Current 25

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Prior Page

Current 1

Relation Type	Co-Occuring Concept Count	Relationship	Concept
DISO_to_DISO	174		chemically induced C0007994
DISO_to_DISO	124		chemically induced C0007994
DISO_to_DISO	89		Dermatitis, Atopic C0011615
DISO_to_CHEM	81		Antipruritics C0003417
DISO_to_CHEM	66		Antipruritics C0003417
DISO_to_DISO	52		Dermatitis, Atopic C0011615
DISO_to_DISO	48		Pain C0030193
DISO_to_DISO	47		Complication Aspects C1171258
DISO_to_ANAT	46		Skin C1123023
DISO_to_DISO	40		Complication Aspects C1171258
DISO_to_DISO	35		Uremia C0041948
DISO_to_ANAT	34		Skin C1123023
DISO_to_DISO	33		BILIARY STASIS C0008370
DISO_to_DISO	32		Pregnancy Complications C0032962
DISO_to_DISO	30		Uremia C0041948
DISO_to_DISO	29		Pain C0030193
DISO_to_ANAT	27		In Blood C0005768
DISO_to_DISO	27		BILIARY STASIS C0008370
DISO_to_DISO	27		Pregnancy Complications C0032962
DISO_to_DISO	26		Kidney Failure, Chronic C0022661
DISO_to_DISO	25		Dermatologic disorders C0037274
DISO_to_DISO	24		Exanthema C0015230
DISO_to_CHEM	23		Analgesics, Opioid C0002772
DISO_to_DISO	23		Burn injury C0006434
DISO_to_DISO	22		PSORIASIS C0033860

Genes (18)

Species:

human : 18

Species	Gene	GeneId	Gene Name	Evidence
Human	IL31	386653	interleukin 31	GENERIF, Score=694, Pubmed Id: 15925362, UMLKSK CUI: C0033774 Findings suggest that IL-31 may participate in the cause of itch sensation and promote scratching behavior in NC/Nga mice with atopic dermatitis GENERIF, Score=812, Pubmed Id: 17900679, UMLKSK CUI: C0033774 This study presents the first genetic risk factor for the nonatopic type of eczema and indicates a primary role of IL-31-induced pruritus in the initiation of this disease GENERIF, Score=1000, Pubmed Id: 18678344, UMLKSK CUI: C0033774 serum IL-31 levels were significantly higher in patients with atopic dermatitis (AD) compared with control subjects; findings provide evidence that IL-31 has a role in AD pathophysiology with regard to pruritus and skin inflammation GENERIF, Score=1000, Pubmed Id: 16461143, UMLKSK CUI: C0033774 IL-31 expression is associated with CLA(+) T cells and might contribute to the development of atopic dermatitis-induced skin inflammation and pruritus
Human	ATOD5	117188	Dermatitis, atopic, 5	OMIM, Score=1000, UMLKSK CUI: C0033774 Pruritus (major feature)
Human	ATOD3	117187	Dermatitis, atopic, 3	OMIM, Score=1000, UMLKSK CUI: C0033774 Pruritus (major feature)
Human	ATOD6	114477	Dermatitis, atopic, 6	OMIM, Score=1000, UMLKSK CUI: C0033774 Pruritus (major feature)
Human	ITCH	83737	itchy E3 ubiquitin protein ligase	GENERIF, Score=1000, Pubmed Id: 18805400, UMLKSK CUI: C0033774 hypothesize a correlated slow-frequency motion that involves two different hinge regions of the HECT domain of itch GENERIF, Score=1000, Pubmed Id: 15703212, UMLKSK CUI: C0033774 Both neural precursor cell expressed, developmentally down-regulated 4 and Itch participate in the degradation of Melan-A GENERIF, Score=1000, Pubmed Id: 15469925, UMLKSK CUI: C0033774 The visualization of ubiquitinated Jun in living cells has uncovered a lysosomal pathway for Jun degradation that involves ubiquitination by Itch/AIP4 GENERIF, Score=1000, Pubmed Id: 18628966, UMLKSK CUI: C0033774 AIP4/Itch regulates Notch receptor degradation in the absence of ligand GENERIF, Score=1000, Pubmed Id: 19001863, UMLKSK CUI: C0033774 Itch gene sequence is highly conserved in healthy subjects; no relevant SNPs located in putative functional regions of Itch were found in atopic dermatitis and rheumatoid arthritis patients GENERIF, Score=1000, Pubmed Id: 19090833, UMLKSK CUI: C0033774 Ubiquitination of cFLIP(L) inhibits the interaction between cFLIP(L) and Itch in T. cruzi-infected cells GENERIF, Score=1000, Pubmed Id: 18718448, UMLKSK CUI: C0033774 This is the first in vivo evidence for the interaction between p45/NF-E2 and the E3 ubiquitin ligase Itch, and the subsequent ubiquitination of p45/NF-E2 by Itch GENERIF, Score=827, Pubmed Id: 15678106, UMLKSK CUI: C0033774 Upon DNA damage Itch itself is downregulated, allowing p73 protein levels to rise and thus interfere with p73 function GENERIF, Score=660, Pubmed Id: 17115028, UMLKSK CUI: C0033774 Hedgehog transcription factor Gli1 is targeted by Numb for Itch-dependent ubiquitination, which suppresses Hedgehog signals, thus arresting growth and promoting cell differentiation GENERIF, Score=1000, Pubmed Id: 19016753, UMLKSK CUI: C0033774 ITCH is a putative target for a novel 20q11.22 amplification detected in anaplastic thyroid carcinoma cells by array-based comparative genomic hybridization
Human	TGM5	9333	transglutaminase 5	OMIM, Score=1000, UMLKSK CUI: C0033774 Pruritus (inflammatory type B)
Human	OSMR	9180	oncostatin M receptor	OMIM, Score=1000, UMLKSK CUI: C0033774 Pruritus
Human	ABCB11	8647	ATP-binding cassette, sub-family B (MDR/TAP), member 11	OMIM, Score=1000, UMLKSK CUI: C0033774 Pruritus
Human	TP73	7161	tumor protein p73	GENERIF, Score=827, Pubmed Id: 15678106, UMLKSK CUI: C0033774 Upon DNA damage Itch itself is downregulated, allowing p73 protein levels to rise and thus interfere with p73 function
Human	ABCB4	5244	ATP-binding cassette, sub-family B (MDR/TAP), member 4	OMIM, Score=1000, UMLKSK CUI: C0033774 Pruritus during pregnancy OMIM, Score=1000, UMLKSK CUI: C0033774 Pruritus
Human	ATP8B1	5205	ATPase, aminophospholipid transporter, class I, type 8B, member 1	OMIM, Score=1000, UMLKSK CUI: C0033774 Pruritus OMIM, Score=1000, UMLKSK CUI: C0033774 Pruritus, episodic
Human	PDGFRA	5156	platelet-derived growth factor receptor, alpha polypeptide	OMIM, Score=1000, UMLKSK CUI: C0033774 Pruritus
Human	NOTCH1	4851	notch 1	GENERIF, Score=1000, Pubmed Id: 18628966, UMLKSK CUI: C0033774 AIP4/Itch regulates Notch receptor degradation in the absence of ligand
Human	NEDD4	4734	neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase	GENERIF, Score=795, Pubmed Id: 15703212, UMLKSK CUI: C0033774 Both NEDD4 and ubiquitin protein ligase ubiquitin protein ligase Itch participate in the degradation of Melan-A
Human	FLG	2312	filaggrin	OMIM, Score=1000, UMLKSK CUI: C0033774 Pruritus (major feature)
Human	FECH	2235	ferrochelatase	OMIM, Score=1000, UMLKSK CUI: C0033774 Itching
Human	CALCA	796	calcitonin-related polypeptide alpha	GENERIF, Score=861, Pubmed Id: 18211417, UMLKSK CUI: C0033774 Significantly higher CGRP concentration was observed in atopic dermatitis patients suffering from severe pruritus
Human	ATP2A2	488	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	OMIM, Score=1000, UMLKSK CUI: C0033774 Itch, pain, and body malodor often

XRefs (1)

XRef Types:

cui : 1

ToppGene Datasets:

none : 1

ToppGene Datasets	XRef Type	XRef Id	XRef	Values	Source	Top % Rank
	CUI	C0033774	Pruritus	0		self

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