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Genes (18)
Species: human : 18 | |
Human | IL31 | 386653 | interleukin 31 | This study presents the first genetic risk factor for the nonatopic type of eczema and indicates a primary role of IL-31-induced pruritus in the initiation of this disease IL-31 expression is associated with CLA(+) T cells and might contribute to the development of atopic dermatitis-induced skin inflammation and pruritus serum IL-31 levels were significantly higher in patients with atopic dermatitis (AD) compared with control subjects; findings provide evidence that IL-31 has a role in AD pathophysiology with regard to pruritus and skin inflammation Findings suggest that IL-31 may participate in the cause of itch sensation and promote scratching behavior in NC/Nga mice with atopic dermatitis | Human | ATOD5 | 117188 | Dermatitis, atopic, 5 | | Human | ATOD3 | 117187 | Dermatitis, atopic, 3 | | Human | ATOD6 | 114477 | Dermatitis, atopic, 6 | | Human | ITCH | 83737 | itchy E3 ubiquitin protein ligase | This is the first in vivo evidence for the interaction between p45/NF-E2 and the E3 ubiquitin ligase Itch, and the subsequent ubiquitination of p45/NF-E2 by Itch hypothesize a correlated slow-frequency motion that involves two different hinge regions of the HECT domain of itch Itch gene sequence is highly conserved in healthy subjects; no relevant SNPs located in putative functional regions of Itch were found in atopic dermatitis and rheumatoid arthritis patients Hedgehog transcription factor Gli1 is targeted by Numb for Itch-dependent ubiquitination, which suppresses Hedgehog signals, thus arresting growth and promoting cell differentiation Ubiquitination of cFLIP(L) inhibits the interaction between cFLIP(L) and Itch in T. cruzi-infected cells AIP4/Itch regulates Notch receptor degradation in the absence of ligand Both neural precursor cell expressed, developmentally down-regulated 4 and Itch participate in the degradation of Melan-A Upon DNA damage Itch itself is downregulated, allowing p73 protein levels to rise and thus interfere with p73 function ITCH is a putative target for a novel 20q11.22 amplification detected in anaplastic thyroid carcinoma cells by array-based comparative genomic hybridization The visualization of ubiquitinated Jun in living cells has uncovered a lysosomal pathway for Jun degradation that involves ubiquitination by Itch/AIP4 | Human | TGM5 | 9333 | transglutaminase 5 | Pruritus (inflammatory type B) | Human | OSMR | 9180 | oncostatin M receptor | | Human | ABCB11 | 8647 | ATP-binding cassette, sub-family B (MDR/TAP), member 11 | | Human | TP73 | 7161 | tumor protein p73 | Upon DNA damage Itch itself is downregulated, allowing p73 protein levels to rise and thus interfere with p73 function | Human | ABCB4 | 5244 | ATP-binding cassette, sub-family B (MDR/TAP), member 4 | Pruritus during pregnancy | Human | ATP8B1 | 5205 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | | Human | PDGFRA | 5156 | platelet-derived growth factor receptor, alpha polypeptide | | Human | NOTCH1 | 4851 | notch 1 | AIP4/Itch regulates Notch receptor degradation in the absence of ligand | Human | NEDD4 | 4734 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | Both NEDD4 and ubiquitin protein ligase ubiquitin protein ligase Itch participate in the degradation of Melan-A | Human | FLG | 2312 | filaggrin | | Human | FECH | 2235 | ferrochelatase | | Human | CALCA | 796 | calcitonin-related polypeptide alpha | Significantly higher CGRP concentration was observed in atopic dermatitis patients suffering from severe pruritus | Human | ATP2A2 | 488 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | Itch, pain, and body malodor often |
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