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Genes (18)
Species: human : 18 | |
| Human | IL31 | 386653 | interleukin 31 | Findings suggest that IL-31 may participate in the cause of itch sensation and promote scratching behavior in NC/Nga mice with atopic dermatitis This study presents the first genetic risk factor for the nonatopic type of eczema and indicates a primary role of IL-31-induced pruritus in the initiation of this disease serum IL-31 levels were significantly higher in patients with atopic dermatitis (AD) compared with control subjects; findings provide evidence that IL-31 has a role in AD pathophysiology with regard to pruritus and skin inflammation IL-31 expression is associated with CLA(+) T cells and might contribute to the development of atopic dermatitis-induced skin inflammation and pruritus | | Human | ATOD5 | 117188 | Dermatitis, atopic, 5 | | | Human | ATOD3 | 117187 | Dermatitis, atopic, 3 | | | Human | ATOD6 | 114477 | Dermatitis, atopic, 6 | | | Human | ITCH | 83737 | itchy E3 ubiquitin protein ligase | The visualization of ubiquitinated Jun in living cells has uncovered a lysosomal pathway for Jun degradation that involves ubiquitination by Itch/AIP4 hypothesize a correlated slow-frequency motion that involves two different hinge regions of the HECT domain of itch Both neural precursor cell expressed, developmentally down-regulated 4 and Itch participate in the degradation of Melan-A ITCH is a putative target for a novel 20q11.22 amplification detected in anaplastic thyroid carcinoma cells by array-based comparative genomic hybridization This is the first in vivo evidence for the interaction between p45/NF-E2 and the E3 ubiquitin ligase Itch, and the subsequent ubiquitination of p45/NF-E2 by Itch Upon DNA damage Itch itself is downregulated, allowing p73 protein levels to rise and thus interfere with p73 function Itch gene sequence is highly conserved in healthy subjects; no relevant SNPs located in putative functional regions of Itch were found in atopic dermatitis and rheumatoid arthritis patients Ubiquitination of cFLIP(L) inhibits the interaction between cFLIP(L) and Itch in T. cruzi-infected cells Hedgehog transcription factor Gli1 is targeted by Numb for Itch-dependent ubiquitination, which suppresses Hedgehog signals, thus arresting growth and promoting cell differentiation AIP4/Itch regulates Notch receptor degradation in the absence of ligand | | Human | TGM5 | 9333 | transglutaminase 5 | Pruritus (inflammatory type B) | | Human | OSMR | 9180 | oncostatin M receptor | | | Human | ABCB11 | 8647 | ATP-binding cassette, sub-family B (MDR/TAP), member 11 | | | Human | TP73 | 7161 | tumor protein p73 | Upon DNA damage Itch itself is downregulated, allowing p73 protein levels to rise and thus interfere with p73 function | | Human | ABCB4 | 5244 | ATP-binding cassette, sub-family B (MDR/TAP), member 4 | Pruritus during pregnancy | | Human | ATP8B1 | 5205 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | | | Human | PDGFRA | 5156 | platelet-derived growth factor receptor, alpha polypeptide | | | Human | NOTCH1 | 4851 | notch 1 | AIP4/Itch regulates Notch receptor degradation in the absence of ligand | | Human | NEDD4 | 4734 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | Both NEDD4 and ubiquitin protein ligase ubiquitin protein ligase Itch participate in the degradation of Melan-A | | Human | FLG | 2312 | filaggrin | | | Human | FECH | 2235 | ferrochelatase | | | Human | CALCA | 796 | calcitonin-related polypeptide alpha | Significantly higher CGRP concentration was observed in atopic dermatitis patients suffering from severe pruritus | | Human | ATP2A2 | 488 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | Itch, pain, and body malodor often |
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