Genes (268)
Species: human : 260 mouse : 8 | |
Mouse | OLFM4 | 10562 | olfactomedin 4 | Finally, forced overexpression of GW112 in murine prostate tumor cells led to more rapid tumor formation in a syngeneic host. | Mouse | TNFRSF11B | 4982 | tumor necrosis factor receptor superfamily, member 11b | Osteoprotegerin inhibits prostate cancer-induced osteoclastogenesis and prevents prostate tumor growth in the bone. | Mouse | HIP1 | 3092 | huntingtin interacting protein 1 | In addition to human cancers, HIP1 is also overexpressed in prostate tumors from the transgenic adenocarcinoma of the mouse prostate (TRAMP) mouse model. In addition, the expression of HIP1 was elevated in prostate tumors from the transgenic mouse model of prostate cancer (TRAMP). | Mouse | HAS3 | 3038 | hyaluronan synthase 3 | We have previously shown that aggressive PC3M-LN4 prostate tumor cells synthesize excessive HA relative to less aggressive cells, and express correspondingly higher levels of the HA biosynthetic enzymes HAS2 and HAS3. | Mouse | HBEGF | 1839 | heparin-binding EGF-like growth factor | Heparin-binding epidermal growth factor-like growth factor stimulates androgen-independent prostate tumor growth and antagonizes androgen receptor function. | Mouse | CDKN2C | 1031 | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) | The remaining wild-type allele of Pten was lost at a high frequency in Pten(+/-) cells but not in p18(+/-) Pten(+/-) or p18(-/-) Pten(+/-) prostate tumor cells, nor in other Pten(+/-) tumor cells, suggesting a tissue- and genetic background-dependent haploinsufficiency of Pten in tumor suppression. p18 deletion, CDK4 overexpression, or oncoviral inactivation of Rb family proteins caused activation of Akt/PKB that was recessive to the reduction of PTEN activity. | Mouse | CAV1 | 857 | caveolin 1, caveolae protein, 22kDa | Inactivation of one (+/-) or both (-/-) alleles of Cav-1 resulted in significant reductions in prostate tumor burden, as well as decreases in regional lymph node metastases. Caveolin-1 Promotes Tumor Progression in an Autochthonous Mouse Model of Prostate Cancer: GENETIC ABLATION OF Cav-1 DELAYS ADVANCED PROSTATE TUMOR DEVELOPMENT IN TRAMP MICE. | Mouse | RHOA | 387 | ras homolog family member A | Role of RhoA activation in the growth and morphology of a murine prostate tumor cell line. | Human | MUC5B | 727897 | mucin 5B, oligomeric mucus/gel-forming | Using PAC120, a xenograft of a human hormone-dependent prostate tumour, and its hormone-independent variants, we analysed the expression of mucins (MUC1, MUC2, MUC4, MUC5AC, MUC5B, MUC6) by immunohistochemistry or reverse transcriptase (RT)-PCR. | Human | TBC1D3B | 414059 | TBC1 domain family, member 3B | We used cDNA-based genomic microarrays to examine DNA copy number changes in a panel of prostate tumors and found a previously undescribed amplicon on chromosome 17 containing a novel overexpressed gene that we termed prostate cancer gene 17 (PRC17). PRC17 is amplified in 15% of prostate cancers, it is highly overexpressed in approximately one-half of metastatic prostate tumors Whereas PRC17 is amplified in 15% of prostate cancers, it is highly overexpressed in approximately one-half of metastatic prostate tumors. | Human | RASL11A | 387496 | RAS-like, family 11, member A | We determined by Northern blot that RASL11A is transcribed in several human tissues and that it is down-regulated in prostate tumors as measured by quantitative real-time PCR. RASL11A, member of a novel small monomeric GTPase gene family, is down-regulated in prostate tumors. | Human | RGSL1 | 353299 | regulator of G-protein signaling like 1 | RGSL1 and RGLS2 expression was detected by real-time polymerase chain reaction in normal prostate tissue, but could not be detected in prostate tumor cell lines, suggesting they might have a role in prostate cancer. | Human | STEAP2 | 261729 | STEAP family member 2, metalloreductase | Consistent with this notion, in situ analysis of human prostate cancer specimens indicated that STAMP1 is expressed exclusively in the epithelial cells of the prostate and its expression is significantly increased in prostate tumors compared with normal glands. cloning and characterization of STAMP1, which is expressed in both normal prostate and prostate neoplasms | Human | CADM4 | 199731 | cell adhesion molecule 4 | Cell adhesion and prostate tumor-suppressor activity of TSLL2/IGSF4C, an immunoglobulin superfamily molecule homologous to TSLC1/IGSF4. | Human | SLC5A8 | 160728 | solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 | DNA methylation in the SLC5A8 promoter region suppressed the expression of SLC5A8 in prostate tumor | Human | SLC2A12 | 154091 | solute carrier family 2 (facilitated glucose transporter), member 12 | In human breast and prostate tumors and cultured cells, GLUT12 is located intracellularly and at the cell surface. | Human | DAB2IP | 153090 | DAB2 interacting protein | Analysis of SNPs indicated that one, rs1571801, located in the DAB2IP gene, which encodes a novel Ras GTPase-activating protein and putative prostate tumor suppressor, was associated with aggressive prostate cancer | Human | CREB3L4 | 148327 | cAMP responsive element binding protein 3-like 4 | The highly tissue-specific expression profile, androgen regulation, chromosomal localization, and expression profile of AIbZIP in prostate tumors suggest that AIbZIP may play an important role in prostate cancer and in androgen receptor signaling in prostate cells. AIbZIP, a novel bZIP gene located on chromosome 1q21.3 that is highly expressed in prostate tumors and of which the expression is up-regulated by androgens in LNCaP human prostate cancer cells. AIbZIP, a novel bZIP gene located on chromosome 1q21.3 that is highly expressed in prostate tumors and of which the expression is up-regulated by androgens in LNCaP human prostate cancer cells | Human | GDEP | 118425 | | Loss of heterozygosity in prostate tumors has also been reported at the location of PCan1. In an effort to understand the molecular events leading to prostate cancer, we have identified PCAN1 (prostate cancer gene 1) (also known as GDEP), a gene that is highly expressed in prostate epithelial tissue and frequently mutated in prostate tumors. | Human | SCGB3A1 | 92304 | secretoglobin, family 3A, member 1 | Nearly all prostate and a significant fraction of lung and pancreatic carcinomas showed HIN-1 hypermethylation, and the majority of lung and prostate tumors lacked HIN-1 expression. | Human | ANKRD30A | 91074 | ankyrin repeat domain 30A | We now show that NY-BR-1 is also sporadically expressed in normal prostate and in 32% of prostate tumors. | Human | SLC45A3 | 85414 | solute carrier family 45, member 3 | Furthermore, prostein mRNA expression does not appear to be prostate tumor grade related and is restricted exclusively to prostate cell lines. | Human | IL17RC | 84818 | interleukin 17 receptor C | In an in vivo model of human prostate tumor growth in nude mice (CWR22 xenograft model), IL-17RL expression in tumors was induced by androgen deprivation. | Human | LZTS2 | 84445 | leucine zipper, putative tumor suppressor 2 | LAPSER1 is expressed at the highest levels in normal prostate and testis, where multiple isoforms are seen, some of which are either undetectable or differentially expressed in some prostate tumor tissues and cell lines. | Human | TBC1D3F | 84218 | TBC1 domain family, member 3F | We used cDNA-based genomic microarrays to examine DNA copy number changes in a panel of prostate tumors and found a previously undescribed amplicon on chromosome 17 containing a novel overexpressed gene that we termed prostate cancer gene 17 (PRC17). Whereas PRC17 is amplified in 15% of prostate cancers, it is highly overexpressed in approximately one-half of metastatic prostate tumors. We describe eight highly related TBC1D3 paralogues located on Chromosome 17q12 that display specific transcription patterns in human tissues, and that pattern is altered in several primary prostate tumors in comparison to healthy prostate tissues |
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