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Details
Link-It Detail - Disease - Prolactinoma
Debug Stats
  • ### Total Build Time: 95 ms 61.971 KB
  • CONCEPT_NAME gt=2 ms Completed: 2 ms rowSize= 322 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 366 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 187 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=4 ms Completed: 4 ms rowSize= 980 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=39 ms Completed: 39 ms rowSize= 10.422 KB
  • CONCEPT_RELATIONSHIPS gt=24 ms Completed: 24 ms rowSize= 15.737 KB
  • CONCEPT_GENES gt=25 ms Completed: 25 ms rowSize= 32.818 KB
  • CONCEPT_XREFS gt=1 ms Completed: 1 ms rowSize= 1.146 KB
  • CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Prolactinoma C0033375
Definition (1)
A pituitary adenoma which secretes PROLACTIN, leading to HYPERPROLACTINEMIA. Clinical manifestations include AMENORRHEA; GALACTORRHEA; IMPOTENCE; HEADACHE; visual disturbances; and CEREBROSPINAL FLUID RHINORRHEA.
Semantic Types (1)
Neoplastic Process (T191)
Parents (2)
img Pituitary Neoplasms C0032019
img Adenoma C0001430
Ancestral Roots
RootRoot Plus OneDepthParent
img Neoplasms C0027651img Neoplasms by Site C00276535img Pituitary Neoplasms C0032019
img Endocrine System Diseases C0014130img Endocrine Gland Neoplasms C00141324img Pituitary Neoplasms C0032019
img Nervous System Diseases C0027765img Central Nervous System Diseases C00076827img Pituitary Neoplasms C0032019
img Neoplasms C0027651img Neoplasms by Site C00276539img Pituitary Neoplasms C0032019
img Nervous System Diseases C0027765img Nervous System Neoplasms C00277668img Pituitary Neoplasms C0032019
img Nervous System Diseases C0027765img Central Nervous System Diseases C00076828img Pituitary Neoplasms C0032019
img Endocrine System Diseases C0014130img Pituitary Diseases C00320024img Pituitary Neoplasms C0032019
img Neoplasms C0027651img Neoplasms by Histologic Type C00276525img Adenoma C0001430
Relationships (78)

Relation Types:
diso_​to_​anat : 26
diso_​to_​chem : 13
diso_​to_​diso : 34
diso_​to_​phen : 4
diso_​to_​phys : 1


Relationships:
none : 33
gene_​product_​malfunction_​associated_​with_​disease : 1
is_​abnormal_​cell_​of_​disease : 5
is_​associated_​anatomic_​site_​of : 9
is_​finding_​of_​disease : 1
is_​normal_​cell_​origin_​of_​disease : 3
is_​normal_​tissue_​origin_​of_​disease : 2
is_​not_​abnormal_​cell_​of_​disease : 2
is_​not_​finding_​of_​disease : 1
is_​primary_​anatomic_​site_​of_​disease : 2
isa : 4
may_​be_​cytogenetic_​abnormality_​of_​disease : 11
may_​be_​molecular_​abnormality_​of_​disease : 2
permuted_​term_​of : 1
used_​for : 1
Page Size
Current 25
  Page 1 of 4
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_DISO274img Pituitary Neoplasms C0032019
DISO_to_DISO272img Pituitary Neoplasms C0032019
DISO_to_DISO92img Complication Aspects C1171258
DISO_to_DISO68img Complication Aspects C1171258
DISO_to_CHEM62img Dopamine Agonists C0178601
DISO_to_CHEM53img Ergolines C0014699
DISO_to_ANAT50img In Blood C0005768
DISO_to_ANAT46img In Blood C0005768
DISO_to_CHEM43img Dopamine Agonists C0178601
DISO_to_CHEM42img Prolactin C0033371
DISO_to_CHEM37img Prolactin C0033371
DISO_to_DISO37img Hyperprolactinemia C0020514
DISO_to_DISO30img Hyperprolactinemia C0020514
DISO_to_PHEN30img genetic aspects C0017399
DISO_to_CHEM26img Ergolines C0014699
DISO_to_PHEN23img genetic aspects C0017399
DISO_to_CHEM22img Antineoplastic Agents C0003392
DISO_to_DISO22img Adenoma C0001430
DISO_to_CHEM18img 2 Bromo alpha ergocryptine C0006230
DISO_to_DISO18img Adenoma C0001430
DISO_to_CHEM16img Antineoplastic Agents C0003392
DISO_to_PHEN16img Process of secretion C0036536
DISO_to_ANAT15img Pituitary Gland C0032005
DISO_to_CHEM15img 2 Bromo alpha ergocryptine C0006230
DISO_to_DISO14img chemically induced C0007994
Genes (21)

Species:
human : 20
mouse : 1
SpeciesGeneGeneIdGene NameEvidence
MouseHMGA28091high mobility group AT-hook 2
img NCI, Score=801, Pubmed Id: 11956103, UMLKSK CUI: C0033375
HumanTUBA1C84790tubulin, alpha 1c
img NCI, Score=801, Pubmed Id: 3905419, UMLKSK CUI: C0033375
img NCI, Score=801, Pubmed Id: 3905419, UMLKSK CUI: C0033375
HumanPTTG19232pituitary tumor-transforming 1
img NCI, Score=801, Pubmed Id: 12554778, UMLKSK CUI: C0033375
HumanAIP9049aryl hydrocarbon receptor interacting protein
img OMIM, Score=1000, UMLKSK CUI: C0033375
img OMIM, Score=1000, UMLKSK CUI: C0033375
HumanHMGA28091high mobility group AT-hook 2
img NCI, Score=801, Pubmed Id: 11956103, UMLKSK CUI: C0033375
img NCI, Score=801, Pubmed Id: 16322327, UMLKSK CUI: C0033375
img NCI, Score=801, Pubmed Id: 11956103, UMLKSK CUI: C0033375
HumanTIMP27077TIMP metallopeptidase inhibitor 2
img NCI, Score=801, Pubmed Id: 12904990, UMLKSK CUI: C0033375
HumanSSTR56755somatostatin receptor 5
img NCI, Score=801, Pubmed Id: 7521350, UMLKSK CUI: C0033375
img OMIM, Score=1000, UMLKSK CUI: C0033375
img NCI, Score=801, Pubmed Id: 10487698, UMLKSK CUI: C0033375
img NCI, Score=801, Pubmed Id: 9410919, UMLKSK CUI: C0033375
img NCI, Score=801, Pubmed Id: 7908405, UMLKSK CUI: C0033375
HumanSNRPN6638small nuclear ribonucleoprotein polypeptide N
img NCI, Score=801, Pubmed Id: 8872033, UMLKSK CUI: C0033375
HumanSNAP256616synaptosomal-associated protein, 25kDa
img GENERIF, Score=1000, Pubmed Id: 18633321, UMLKSK CUI: C0033375
HumanPCNA5111proliferating cell nuclear antigen
img GENERIF, Score=1000, Pubmed Id: 16201313, UMLKSK CUI: C0033375
HumanNGFR4804nerve growth factor receptor
img GENERIF, Score=660, Pubmed Id: 11818506, UMLKSK CUI: C0033375
HumanGNAS2778GNAS complex locus
img OMIM, Score=1000, UMLKSK CUI: C0033375
HumanGHSR2693growth hormone secretagogue receptor
img NCI, Score=801, Pubmed Id: 11422110, UMLKSK CUI: C0033375
HumanGHRH2691growth hormone releasing hormone
img NCI, Score=801, Pubmed Id: 2858494, UMLKSK CUI: C0033375
HumanFGF42249fibroblast growth factor 4
img NCI, Score=801, Pubmed Id: 8100831, UMLKSK CUI: C0033375
img NCI, Score=801, Pubmed Id: 9509064, UMLKSK CUI: C0033375
img NCI, Score=801, Pubmed Id: 8550832, UMLKSK CUI: C0033375
HumanFGF12246fibroblast growth factor 1 (acidic)
img NCI, Score=801, Pubmed Id: 8219356, UMLKSK CUI: C0033375
HumanDRD21813dopamine receptor D2
img NCI, Score=801, Pubmed Id: 1834494, UMLKSK CUI: C0033375
img GENERIF, Score=660, Pubmed Id: 11818506, UMLKSK CUI: C0033375
img NCI, Score=801, Pubmed Id: 12972179, UMLKSK CUI: C0033375
HumanCOMT1312catechol-O-methyltransferase
img NCI, Score=801, Pubmed Id: 6593325, UMLKSK CUI: C0033375
HumanCNTF1270ciliary neurotrophic factor
img NCI, Score=801, Pubmed Id: 11375124, UMLKSK CUI: C0033375
HumanCDH1999cadherin 1, type 1, E-cadherin (epithelial)
img GENERIF, Score=1000, Pubmed Id: 12481018, UMLKSK CUI: C0033375
HumanBMP4652bone morphogenetic protein 4
img NCI, Score=801, Pubmed Id: 12552124, UMLKSK CUI: C0033375
img NCI, Score=801, Pubmed Id: 12552124, UMLKSK CUI: C0033375
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0033375Prolactinoma0self