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Details
Link-It Detail - Disease - Preleukemia
Debug Stats
  • ### Total Build Time: 58 ms 13.244 KB
  • CONCEPT_NAME gt=7 ms Completed: 7 ms rowSize= 320 bytes
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  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Preleukemia C0033027
Definition (1)

Your bone marrow is the spongy tissue inside some of your bones, such as your hip and thigh bones. It contains immature cells, called stem cells. The stem cells can develop into the red blood cells that carry oxygen through your body, the white blood cells that fight infections, and the platelets that help with blood clotting. If you have a myelodysplastic syndrome, the stem cells do not mature into healthy blood cells. This leaves less room for healthy cells, which can lead to infection, anemia, or easy bleeding.

Myelodysplastic syndromes often do not cause early symptoms and are sometimes found during a routine blood test. If you have symptoms, they may include

  • Shortness of breath
  • Weakness or feeling tired
  • Skin that is paler than usual
  • Easy bruising or bleeding
  • Pinpoint spots under the skin caused by bleeding
  • Fever or frequent infections

Myelodysplastic syndromes are rare. People at higher risk are over 60, have had chemotherapy or radiation therapy, or have been exposed to certain chemicals. Treatment options include transfusions, drug therapy, chemotherapy, and blood or bone marrow stem cell transplants.

NIH National Cancer Institute

Semantic Types (1)
Neoplastic Process (T191)
Parents (2)
img Precancerous Conditions C0032927
img Hematologic Diseases C0018939
Ancestral Roots
RootRoot Plus OneDepthParent
img Neoplasms C0027651img Precancerous Conditions C00329273img Precancerous Conditions C0032927
img Hemic and Lymphatic Diseases C0018981img Hematologic Diseases C00189393img Hematologic Diseases C0018939
Relationships (9)

Relation Types:
diso_​to_​chem : 2
diso_​to_​diso : 5
diso_​to_​phen : 2


Relationships:
none : 7
permuted_​term_​of : 1
related_​to : 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_PHEN12img genetic aspects C0017399
DISO_to_PHEN11img genetic aspects C0017399
DISO_to_CHEM6img Chimeric Oncogene Proteins C0029014
DISO_to_CHEM5img Chimeric Oncogene Proteins C0029014
DISO_to_DISO4img Myelodysplastic Syndromes C0026986
DISO_to_DISO4img Precursor B-Cell Lymphoblastic Leukemia-Lymphoma C0023485
DISO_to_DISO4img Precursor Cell Lymphoblastic Leukemia Lymphoma C1961102
DISO_to_DISOrelated_toimg Bone Marrow Diseases C0005956
DISO_to_DISOpermuted_term_ofimg Preleukemia C0033027
Genes (1)

Species:
human : 1
SpeciesGeneGeneIdGene NameEvidence
HumanNRAS4893neuroblastoma RAS viral (v-ras) oncogene homolog
img GENERIF, Score=1000, Pubmed Id: 12393454, UMLKSK CUI: C0033027
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0033027Preleukemia0self