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Genes (162)
Species: human : 162 | |
Human | CD24 | 100133941 | CD24 molecule | low expression of CD24 may cause the enhanced immune reaction and could play a role in the abnormal development of placenta in pre-eclampsia | Human | LOC391533 | 391533 | | Increased soluble fms-like tyrosine kinase 1 is more likely to be present in women with severe preeclampsia, but it is not present in all women with preeclampsia | Human | KIR3DL3 | 115653 | killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3 | Allelic sequence polymorphism at the KIR3DL3 is associated with pre-Eclampsia | Human | NOD2 | 64127 | nucleotide-binding oligomerization domain containing 2 | TLR4 and NOD2 gene variants are associated with a pro-inflammatory phenotype with a history of early-onset preeclampsia and HELLP syndrome | Human | ERVWE1 | 30816 | | Hypoxia alters expression and function of syncytin and its receptor during trophoblast cell fusion of human placental BeWo cells: implications for impaired trophoblast syncytialisation in pre-eclampsia contributor to normal placental architecture, especially in the fusion processes of cytotrophoblasts to syncytiotrophoblasts. the gene expression of syncytin may be altered in cases with placental dysfunction such as preeclampsia or HELLP syndrome | Human | LGALS13 | 29124 | lectin, galactoside-binding, soluble, 13 | Maternal serum PP13 concentration in the first trimester was significantly lower in patients who developed preterm and early-onset preeclampsia than in those with normal pregnancies parallel to its decreased placental expression, an augmented membrane shedding of PP13 contributes to the increased third trimester maternal serum PP13 concentrations in women with preterm pre-eclampsia and HELLP syndrome screening of maternal PP13 levels in the first trimester is a promising diagnostic tool for the prediction of preeclampsia with high sensitivity and specificity | Human | NOX1 | 27035 | NADPH oxidase 1 | At the immunohistochemical level Nox1 expression was significantly increased in syncytiotrophoblast and endothelial cells in placentas from patients with preeclampsia as compared to gestational age-matched controls | Human | DDAH1 | 23576 | dimethylarginine dimethylaminohydrolase 1 | The first evidence of the importance of DDAH1 polymorphisms in pre-eclampsia susceptibility was provided Title:Haplotypic association of DDAH1 with susceptibility to pre-eclampsia|Association:Y|Conclusion:The observed haplotypic association provides the first evidence of the importance of DDAH1 polymorphisms in pre-eclampsia susceptibility. | Human | SYNPO | 11346 | synaptopodin | We conclude that down-regulation of nephrin and synaptopodin is associated with proteinuria in women with preeclampsia | Human | RASSF1 | 11186 | Ras association (RalGDS/AF-6) domain family member 1 | The median concentrations of hypermethylated RASSF1A (Ras association domain family 1) were 4.3-fold higher in maternal plasma of pre-eclamptic subjects than in controls, with no difference in placental tissues | Human | UTS2 | 10911 | urotensin 2 | study strongly suggest an important role for human Urotensin-II in the pathophysiology of preeclampsia-eclampsia | Human | PLAC1 | 10761 | placenta-specific 1 | CRH, PLAC1, and selectin-P are distributed differently in preeclampsia cases compared to controls and correlate with signs of preeclampsia Plasma PLAC1 and glial cells-missing 1 mRNAs appear promising as noninvasively measurable molecular markers for pre-eclampsia | Human | FST | 10468 | follistatin | Results quantify the relative expression of inhibin alpha, inhibin/activin beta(A), beta(B), beta(C), follistatin, activin receptors and beta-glycan genes in placental tissue of term pre-eclamptic patients | Human | ADIPOQ | 9370 | adiponectin, C1Q and collagen domain containing | Decreased plasma adiponectin concentrations may contribute to the pathophysiology of pre-eclampsia and that adiponectin localized in chorionic vessels may play a role in the restoring of endothelial damage in the feto-maternal units of pre-eclampsia | Human | EBAG9 | 9166 | estrogen receptor binding site associated, antigen, 9 | possible role of the RCAS1 protein in the development of pre-eclampsia through an immunological pathway | Human | APLN | 8862 | apelin | apelin and APJ are expressed in preeclamptic placentas and may have a role in development of preeclampsia | Human | PROZ | 8858 | protein Z, vitamin K-dependent plasma glycoprotein | A high rate of protein Z deficiency is observed in patients with preeclampsia and fetal demise | Human | GCM1 | 8521 | glial cells missing homolog 1 (Drosophila) | Plasma placenta-specific 1 and GCM1 mRNAs appear promising as noninvasively measurable molecular markers for pre-eclampsia Results suggest that GCM1 is a distinct transcription factor involved in placental disease and altered expression of the GCM1 gene may contribute to the etiology of pre-eclampsia | Human | ADAM12 | 8038 | ADAM metallopeptidase domain 12 | ADAM12s in addition to being a potential marker of aneuploidy may also be a marker of pre-eclampsia maternal ADAM12(a disintegrin and metalloproteinase 12) does not provide useful prediction of small for gestational age, preeclampsia, or spontaneous preterm delivery | Human | TFPI2 | 7980 | tissue factor pathway inhibitor 2 | Preeclampsia and IUGR showed distinct distributions of TFPI-2 | Human | VEGFA | 7422 | vascular endothelial growth factor A | Results suggest that carriers of VEGF(+405)G allele have a decreased susceptibility to pre-eclampsia (PE) and that the progression of PE may be modified by the presence of VEGF(-2578)A allele in vivo circulating levels of free VEGF in preeclampsia is likely to contribute to compromised fetoplacental vascular patency in this disease Title:|Association:Not Found|Conclusion:Not Found carriage of the +936T allele of the VEGF gene may be associated with increased susceptibility to the development of preeclampsia and may be an independent risk factor for preeclampsia | Human | VCAM1 | 7412 | vascular cell adhesion molecule 1 | In women with subsequent preeclampsia, sL-selectin and sVCAM-1 concentrations were significantly lower, whereas sE-selectin, sP-selectin and sICAM-1 levels were significantly higher, compared with controls at mid-pregnancy (p<0.05) | Human | TPBG | 7162 | trophoblast glycoprotein | the mRNA expression of trophoblast glycoprotein is up-regulated in cells circulating within blood from women with preeclampsia | Human | TNF | 7124 | tumor necrosis factor | Click here to display 5 evidence detail records. | Human | TLR4 | 7099 | toll-like receptor 4 | TLR-4 protein expression is increased in interstitial trophoblasts of paitents with preeclampsia TLR4 and NOD2 gene variants are associated with a pro-inflammatory phenotype with a history of early-onset preeclampsia and HELLP syndrome No association between TLR4 Asp299Gly and Thr399Ile gene polymorphisms and preeclampsia is indicated |
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