Debug Stats | ### Total Build Time: 106 ms 49.345 KB CONCEPT_NAME gt=4 ms Completed: 4 ms rowSize= 310 bytesCONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytesCONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 443 bytes- Skipping details on:
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CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes CONCEPT_PARENTS gt=6 ms Completed: 6 ms rowSize= 571 bytesCONCEPT_CHILDREN gt=4 ms Completed: 4 ms rowSize= 985 bytesCONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 1.560 KBCONCEPT_RELATIONSHIPS gt=63 ms Completed: 63 ms rowSize= 14.126 KBCONCEPT_GENES gt=27 ms Completed: 27 ms rowSize= 30.050 KBCONCEPT_XREFS gt=1 ms Completed: 1 ms rowSize= 1.141 KBCONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes- Reload Stats
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Genes (200)
Species: human : 194 mouse : 6 | |
Mouse | SOCS2 | 8835 | suppressor of cytokine signaling 2 | Haplotype insufficiency for suppressor of cytokine signaling-2 enhances intestinal growth and promotes polyp formation in growth hormone-transgenic mice. | Mouse | STK11 | 6794 | serine/threonine kinase 11 | Moreover, the LKB1 protein level was not reduced in hamartomatous polyps compared with that in the Lkb1 (+/-) normal gastric mucosa. Because of Lkb1 gene haploinsufficiency, the heterozygous Lkb1 mice develop gastrointestinal polyps of which the histological characteristics resemble those of the Peutz-Jeghers syndrome hamartomas. A genomic PCR and sequence analysis showed that all hamartomas retained both the wild-type and targeted Lkb1 alleles, indicating that allelic loss of the wild-type Lkb1 was not the cause of polyp formation. In most Lkb1 (+/-) mice >20 weeks of age, hamartomatous polyps developed in the glandular stomach, often in the pyloric region. | Mouse | HDAC2 | 3066 | histone deacetylase 2 | Increased HDAC2 expression is found in the majority of human colon cancer explants, as well as in intestinal mucosa and polyps of APC-deficient mice. | Mouse | GUCY2C | 2984 | guanylate cyclase 2C (heat stable enterotoxin receptor) | Lack of guanylyl cyclase C, the receptor for Escherichia coli heat-stable enterotoxin, results in reduced polyp formation and increased apoptosis in the multiple intestinal neoplasia (Min) mouse model. | Mouse | GUCA2B | 2981 | guanylate cyclase activator 2B (uroguanylin) | Our experiments demonstrate that mRNA transcripts for guanylin and uroguanylin are markedly reduced in colon polyps and adenocarcinomas. Uroguanylin treatment suppresses polyp formation in the Apc(Min/+) mouse and induces apoptosis in human colon adenocarcinoma cells via cyclic GMP. | Mouse | CDX1 | 1044 | caudal type homeobox 1 | We also find that Cdx1 expression is lost in Min mouse polyps with increased nuclear localization of beta-catenin, suggesting that Cdx1 does not support beta-catenin-mediated transformation. | Human | MUC5B | 727897 | mucin 5B, oligomeric mucus/gel-forming | INFERRED, Score=800, UMLKSK CUI: C0032584 | Human | CRAC1 | 338377 | colorectal adenoma and carcinoma 1 | We screened these polyps for selected molecular changes, including loss of heterozygosity (LOH) close to APC (5q21) and CRAC1 (15q13-q22), MSI, and mutations of K-ras, APC, p53, and beta-catenin. | Human | NLRP11 | 204801 | NLR family, pyrin domain containing 11 | Eight candidate genes mapping to the breakpoint region--U2AF2, EPN1, NALP4, NALP11, NALP5, ZNF444, PTPRH, and KIAA1811--were screened for mutations in germ-line and polyp DNA from the case and from 15 PJS cases that did not harbor germ-line STK11 mutations. | Human | FLCN | 201163 | folliculin | INFERRED, Score=800, UMLKSK CUI: C0032584 | Human | CLEC4C | 170482 | C-type lectin domain family 4, member C | INFERRED, Score=800, UMLKSK CUI: C0032584 | Human | NLRP5 | 126206 | NLR family, pyrin domain containing 5 | Eight candidate genes mapping to the breakpoint region--U2AF2, EPN1, NALP4, NALP11, NALP5, ZNF444, PTPRH, and KIAA1811--were screened for mutations in germ-line and polyp DNA from the case and from 15 PJS cases that did not harbor germ-line STK11 mutations. | Human | INHBE | 83729 | inhibin, beta E | INFERRED, Score=800, UMLKSK CUI: C0032584 | Human | TPSB2 | 64499 | tryptase beta 2 (gene/pseudogene) | INFERRED, Score=800, UMLKSK CUI: C0032584 | Human | IL22RA1 | 58985 | interleukin 22 receptor, alpha 1 | INFERRED, Score=800, UMLKSK CUI: C0032584 | Human | LTB4R2 | 56413 | leukotriene B4 receptor 2 | INFERRED, Score=800, UMLKSK CUI: C0032584 | Human | CD209 | 30835 | CD209 molecule | INFERRED, Score=800, UMLKSK CUI: C0032584 | Human | TBX21 | 30009 | T-box 21 | | Human | EPN1 | 29924 | epsin 1 | Eight candidate genes mapping to the breakpoint region--U2AF2, EPN1, NALP4, NALP11, NALP5, ZNF444, PTPRH, and KIAA1811--were screened for mutations in germ-line and polyp DNA from the case and from 15 PJS cases that did not harbor germ-line STK11 mutations. | Human | IL17B | 27190 | interleukin 17B | INFERRED, Score=800, UMLKSK CUI: C0032584 | Human | GLS2 | 27165 | glutaminase 2 (liver, mitochondrial) | The content of glutamine and activity of two catabolic enzymes, glutamine transferase and phosphate-dependent glutaminase, were studied in normal colon and in polyp mucosa. Free glutamine content and phosphate-dependent glutaminase activity were studied in the biopsy specimens from the tissue of ulcer, polyps, carcinoma and the surrounding gastric mucosa of patients with precancerous diseases and carcinoma of the stomach. | Human | DNAI1 | 27019 | dynein, axonemal, intermediate chain 1 | INFERRED, Score=800, UMLKSK CUI: C0032584 | Human | IL17RA | 23765 | interleukin 17 receptor A | INFERRED, Score=800, UMLKSK CUI: C0032584 | Human | TMEFF2 | 23671 | transmembrane protein with EGF-like and two follistatin-like domains 2 | HPP1: a transmembrane protein-encoding gene commonly methylated in colorectal polyps and cancers. | Human | AMACR | 23600 | alpha-methylacyl-CoA racemase | In this study, we investigated expression of AMACR in 242 cases of colonic tumors including 176 colorectal carcinomas, 38 colon adenomas and 28 hyperplastic (non-neoplastic) polyps by immunohistochemical analysis. |
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