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Genes (17)
Species: human : 17 | |
Human | FBXW7 | 55294 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | Fbw7 regulates the activity of endoreduplication mediators and the p53 pathway to prevent drug-induced polyploidy | Human | AURKB | 9212 | aurora kinase B | ectopically BRCA2-expressing cells have different intracellular levels of Aurora A, Aurora B, p21, E2F-1, and pRb, suggesting a BRCA2-mediated suppression of polyploidy via stabilization of the checkpoint proteins levels results suggest that endomitotic MKs appropriately express functional Aurora-B kinase and related proteins in early anaphase, making a simple deficiency of this protein an unlikely explanation for polyploidy in this cell type | Human | AURKC | 6795 | aurora kinase C | | Human | AURKA | 6790 | aurora kinase A | ectopically BRCA2-expressing cells have different intracellular levels of Aurora A, Aurora B, p21, E2F-1, and pRb, suggesting a BRCA2-mediated suppression of polyploidy via stabilization of the checkpoint proteins levels | Human | RB1 | 5925 | retinoblastoma 1 | ectopically BRCA2-expressing cells have different intracellular levels of Aurora A, Aurora B, p21, E2F-1, and pRb, suggesting a BRCA2-mediated suppression of polyploidy via stabilization of the checkpoint proteins levels | Human | PIM1 | 5292 | pim-1 oncogene | results indicated that chronic Pim-1 kinase overexpression dysregulates cyclin B1 protein expression, which contributes to the development of polyploidy by delaying cytokinesis Pim-1 is overexpressed in immortalized, non-tumorigenic human prostate and mammary epithelial cells, these cells gradually converted to polyploidy and became tumorigenic | Human | MOS | 4342 | v-mos Moloney murine sarcoma viral oncogene homolog | multiple meiotic genes are aberrantly activated during mitotic catastrophe in p53 mutated lymphoma cells after irradiation; the coordinated expression of MOS and REC8 regulate the extent of arrested mitoses and polyploidy | Human | STMN1 | 3925 | stathmin 1 | These observations support a model in which downregulation of stathmin expression in megakaryocytes and other polyploid cells may be a critically important factor in endomitosis and polyploidy | Human | E2F1 | 1869 | E2F transcription factor 1 | ectopically BRCA2-expressing cells have different intracellular levels of Aurora A, Aurora B, p21, E2F-1, and pRb, suggesting a BRCA2-mediated suppression of polyploidy via stabilization of the checkpoint proteins levels | Human | MAPK14 | 1432 | mitogen-activated protein kinase 14 | study demonstrates that Chk1 inhibition results in the activating phosphorylation of p38 MAPK; results underscore the role of p38 MAPK as a pro-apoptotic kinase in the p53-dependant pathway for the therapeutic elimination of polyploidy cells | Human | CDKN1A | 1026 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | ectopically BRCA2-expressing cells have different intracellular levels of Aurora A, Aurora B, p21, E2F-1, and pRb, suggesting a BRCA2-mediated suppression of polyploidy via stabilization of the checkpoint proteins levels | Human | CCNB1 | 891 | cyclin B1 | results indicated that chronic Pim-1 kinase overexpression dysregulates cyclin B1 protein expression, which contributes to the development of polyploidy by delaying cytokinesis | Human | CASP3 | 836 | caspase 3, apoptosis-related cysteine peptidase | While polyploid, mature megakaryocytes from healthy subjects or myelodysplastic syndromes patients manifested caspase-3 activation during terminal differentiation, freshly isolated, immature MK from MDS died without caspase-3 activation | Human | BUB1B | 701 | BUB1 mitotic checkpoint serine/threonine kinase B | the control of hBubR1 protein level is an important factor in the acquisition of preneoplastic polyploidy | Human | BRCA2 | 675 | breast cancer 2, early onset | ectopically BRCA2-expressing cells have different intracellular levels of Aurora A, Aurora B, p21, E2F-1, and pRb, suggesting a BRCA2-mediated suppression of polyploidy via stabilization of the checkpoint proteins levels | Human | BIRC5 | 332 | baculoviral IAP repeat containing 5 | Data show that mammalian cells lacking survivin are unable to align their chromosomes, fail to recruit Aurora B to kinetochores and become polyploid at a very high frequency | Human | APC | 324 | adenomatous polyposis coli | Loss of APC immediately induces chromosomal instability as a result of a combination of mitotic and apoptotic defects, which may amplify each other to increase the incidence of tetra- and polyploidy in early stages of tumorigenesis |
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