Human | SERPINA12 | 145264 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 | Elevated serum and omental adipose tissue levels of vaspin in overweight polycystic ovary syndrome women and ex vivo regulation of vaspin expression |
Human | FBN3 | 84467 | fibrillin 3 | fibrillin-3 gene showed the strongest evidence for association with Polycystic ovary syndrome |
Human | INHBE | 83729 | inhibin, beta E | In both control and polycystic ovaries, inhibin B was approximately 10-fold higher than activin A and more than 100-fold higher than inhibin A. Follistatin and activin A serum concentrations in obese and non-obese patients with polycystic ovary syndrome. Expression of inhibin/activin system messenger ribonucleic acids and proteins in ovarian follicles from women with polycystic ovarian syndrome. Inhibin A, inhibin B and activin A concentrations in follicular fluid from women with polycystic ovary syndrome. |
Human | QTRT1 | 81890 | queuine tRNA-ribosyltransferase 1 | The frequency of abnormal results obtained from testing for APA, LA, TGT, ETA, and CD56+/CD16- cells among 108 patients with diagnoses of recurrent pregnancy loss (RPL)(n = 45), unexplained infertility (n = 45) including IVF failure (n = 10), endometriosis (n = 10), premature ovarian failure (n = 5), and polycystic ovaries (n = 3) were compared with 15 normal controls. |
Human | ADIPOR2 | 79602 | adiponectin receptor 2 | Upregulated in insulin-resistant women with polycystic ovary syndrome |
Human | FTO | 79068 | fat mass and obesity associated | FTO is a strong influential gene in polycystic ovary syndrome and correlated to various components of MetS including obesity, IFG, glucose intolerance and insulin resistance The predominant effect of FTO variants on polycystic ovary syndrome susceptibility is probably mediated through adiposity |
Human | RETN | 56729 | resistin | Click here to display 6 evidence detail records. |
Human | MMP26 | 56547 | matrix metallopeptidase 26 | expression of transmembrane 4 superfamily member 4 (TM4SF4) and matrix metalloproteinase 26 (MMP26) was found to be significantly decreased during the implantation window in patients with polycystic ovary syndrome |
Human | ITLN1 | 55600 | intelectin 1 (galactofuranose binding) | Omentin-1(ITLN1) is downregulated by insulin and glucose which may explain the decreased omentin-1 levels observed in our overweight women with polycystic ovary syndrome |
Human | FEM1A | 55527 | fem-1 homolog a (C. elegans) | This study presents evidence suggesting a role for FEM1A and FEM1B in the pathogenesis of polycystic ovary syndrome |
Human | GHRL | 51738 | ghrelin/obestatin prepropeptide | Click here to display 5 evidence detail records. |
Human | PPP2R3B | 28227 | protein phosphatase 2, regulatory subunit B'', beta | The identification of PP2A and SET as post-translational regulators of androgen biosynthesis suggests potential additional mechanisms contributing to adrenarche and hyperandrogenic disorders such as polycystic ovary syndrome. |
Human | BSCL2 | 26580 | Berardinelli-Seip congenital lipodystrophy 2 (seipin) | |
Human | LPIN1 | 23175 | lipin 1 | Decreased expression of lipin 1 beta in visceral and subcutaneous adipose tissue appears to contribute to the pathogenesis of insulin resistance in polycystic ovary syndrome |
Human | CAPN10 | 11132 | calpain 10 | Click here to display 8 evidence detail records. |
Human | PPARGC1A | 10891 | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | The polymorphisms of the peroxisome proliferator-activated receptor-gamma (Pro12Ala) and its coactivator-1 (Gly482Ser) genes were investigated among 201 Chinese Han women with polycystic ovary syndrome (PCOS) |
Human | SORBS1 | 10580 | sorbin and SH3 domain containing 1 | SORBS1 polymorphism does not play a major role in premature pubarche, hyperandrogenism, and/or polycystic ovary syndrome in children and adolescent girls |
Human | AGPAT2 | 10555 | 1-acylglycerol-3-phosphate O-acyltransferase 2 | |
Human | FST | 10468 | follistatin | it is concluded that FST is not a susceptibility locus for polycystic ovary syndrome (PCOS); however, the SNP rs3797297 from FST gene was associated with androgenic markers for PCOS and may be of importance in the hyperandrogenaemia of the disease Enlarged polycystic ovaries Title:Evidence for association of polycystic ovary syndrome in caucasian women with a marker at the insulin receptor gene locus|Association:Not Found|Conclusion:In conclusion, our results suggested that a susceptibility gene for PCOS was located on chromosome 19p13.3 in the insulin receptor gene region. It remains to be determined if this susceptibility gene is the insulin receptor gene itself or a closely located gene. Since insulin stimulates androgen secretion by the ovarian stroma it is likely that INSR function in the ovary is involved in the genetic susceptibility ot PCOS. |
Human | NAMPT | 10135 | nicotinamide phosphoribosyltransferase | Visfatin has a role in insulin resistance and markers of hyperandrogenism in lean PCOS patients Women with PCOS exhibit higher plasma visfatin levels than control subjects of similar body mass index |
Human | TBC1D4 | 9882 | TBC1 domain family, member 4 | Impaired insulin signaling through Akt and AS160 in part explains insulin resistance at the molecular level in skeletal muscle in polycystic ovary syndrome |
Human | H6PD | 9563 | hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) | Title:A study of the hexose-6-phosphate dehydrogenase gene R453Q and 11beta-hydroxysteroid dehydrogenase type 1 gene 83557insA polymorphisms in the polycystic ovary syndrome.|Association:Y|Conclusion:Digenic triallelic genotypes of the H6PD R453Q variant and HSD11B1 83557insA mutation do not always cause CRD. On the contrary, the H6PD R453Q variant is associated with PCOS and might influence its phenotype by influencing adrenal activity. |
Human | ADIPOQ | 9370 | adiponectin, C1Q and collagen domain containing | Click here to display 9 evidence detail records. |
Human | SOCS3 | 9021 | suppressor of cytokine signaling 3 | SOCS3 remained significantly unchanged in polycystic ovarian syndrome women |
Human | MGAM | 8972 | maltase-glucoamylase (alpha-glucosidase) | Acarbose has been found to improve insulin levels and thus glucose/insulin ratios more effectively in overweight patients compared with nonoverweight patients with PCOS |