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Details
Link-It Detail - Disease - Poliomyelitis
Debug Stats
  • ### Total Build Time: 160 ms 43.357 KB
  • CONCEPT_NAME gt=7 ms Completed: 7 ms rowSize= 324 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 905 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 188 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 2.265 KB
  • CONCEPT_CHILDREN gt=6 ms Completed: 6 ms rowSize= 1,003 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 14.391 KB
  • CONCEPT_RELATIONSHIPS gt=122 ms Completed: 122 ms rowSize= 13.130 KB
  • CONCEPT_GENES gt=18 ms Completed: 18 ms rowSize= 10.034 KB
  • CONCEPT_XREFS gt=6 ms Completed: 6 ms rowSize= 1.147 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Poliomyelitis C0032371
Definition (1)
An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)
Semantic Types (1)
Disease or Syndrome (T047)
Parents (5)
img Myelitis C0026975
img Neuromuscular Diseases C0027868
img Enterovirus Infections C0014378
img Central Nervous System Viral Diseases C0348165
img Spinal Cord Diseases C0037928
Children (2)
img Poliomyelitis, Bulbar C0032372
img Postpoliomyelitis Syndrome C0080040
Ancestral Roots
RootRoot Plus OneDepthParent
img Virus Diseases C0042769img Central Nervous System Viral Diseases C03481654img Myelitis C0026975
img Nervous System Diseases C0027765img Central Nervous System Diseases C00076826img Myelitis C0026975
img Bacterial Infections and Mycoses C0004615img Central Nervous System Infections C00076845img Myelitis C0026975
img Nervous System Diseases C0027765img Central Nervous System Diseases C00076825img Myelitis C0026975
img Bacterial Infections and Mycoses C0004615img Central Nervous System Infections C00076844img Myelitis C0026975
img Nervous System Diseases C0027765img Neuromuscular Diseases C00278683img Neuromuscular Diseases C0027868
img Virus Diseases C0042769img RNA Virus Infections C00356905img Enterovirus Infections C0014378
img Virus Diseases C0042769img Central Nervous System Viral Diseases C03481653img Central Nervous System Viral Diseases C0348165
img Nervous System Diseases C0027765img Central Nervous System Diseases C00076825img Central Nervous System Viral Diseases C0348165
img Bacterial Infections and Mycoses C0004615img Central Nervous System Infections C00076844img Central Nervous System Viral Diseases C0348165
img Nervous System Diseases C0027765img Central Nervous System Diseases C00076824img Spinal Cord Diseases C0037928
Relationships (42)

Relation Types:
diso_​to_​anat : 4
diso_​to_​chem : 17
diso_​to_​diso : 19
diso_​to_​phen : 2


Relationships:
none : 22
is_​associated_​anatomic_​site_​of : 2
isa : 6
mapped_​to : 2
may_​prevent : 8
use : 1
used_​for : 1
Page Size
Current 25
  Page 1 of 2
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_CHEM190img Oral Poliovirus Vaccine C0032375
DISO_to_CHEM174img Oral Poliovirus Vaccine C0032375
DISO_to_CHEM107img Poliovirus Vaccines C0032374
DISO_to_CHEM101img Poliovirus Vaccines C0032374
DISO_to_PHEN78img Disease Outbreaks C0012652
DISO_to_PHEN69img Disease Outbreaks C0012652
DISO_to_CHEM54img Poliovirus Vaccine, Inactivated C0718003
DISO_to_CHEM47img Poliovirus Vaccine, Inactivated C0718003
DISO_to_DISO46img Complication Aspects C1171258
DISO_to_DISO38img Complication Aspects C1171258
DISO_to_DISO31img Paralysed C0522224
DISO_to_DISO28img Paralysed C0522224
DISO_to_CHEM21img Anti viral antibody C0003253
DISO_to_CHEM19img Anti viral antibody C0003253
DISO_to_ANAT12img In Blood C0005768
DISO_to_DISO12img Disease, Endemic C0277550
DISO_to_DISO11img EXTREMITY PARALYSIS, LOWER C0030486
DISO_to_DISO11img MUSCULAR ATROPHY POSTPOLIO C0080040
DISO_to_ANAT10img In Blood C0005768
DISO_to_CHEM10img Membrane Associated Proteins C0025252
DISO_to_DISO10img Disease due to West Nile virus C0043124
DISO_to_DISO10img EXTREMITY PARALYSIS, LOWER C0030486
DISO_to_ANATis_associated_anatomic_site_ofimg Central Nervous System C0927232
DISO_to_ANATis_associated_anatomic_site_ofimg Nervous System C0027763
DISO_to_CHEMmay_preventimg GLOBULIN,IMMUNE (IM) INJ C0977137
Genes (7)

Species:
human : 7
SpeciesGeneGeneIdGene NameEvidence
HumanRFXANK8625regulatory factor X-associated ankyrin-containing protein
img OMIM, Score=790, UMLKSK CUI: C0032371
img OMIM, Score=1000, UMLKSK CUI: C0032371
HumanRFXAP5994regulatory factor X-associated protein
img OMIM, Score=790, UMLKSK CUI: C0032371
img OMIM, Score=1000, UMLKSK CUI: C0032371
HumanRFX55993regulatory factor X, 5 (influences HLA class II expression)
img OMIM, Score=790, UMLKSK CUI: C0032371
img OMIM, Score=1000, UMLKSK CUI: C0032371
HumanCIITA4261class II, major histocompatibility complex, transactivator
img OMIM, Score=1000, UMLKSK CUI: C0032371
img OMIM, Score=790, UMLKSK CUI: C0032371
HumanICAM13383intercellular adhesion molecule 1
img GENERIF, Score=1000, Pubmed Id: 15353596, UMLKSK CUI: C0032371
HumanFCGR3B2215Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
img GAD, Score=1000, Pubmed Id: 12447772, UMLKSK CUI: C0032371
HumanFCGR3A2214Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
img GAD, Score=1000, Pubmed Id: 12447772, UMLKSK CUI: C0032371
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0032371Poliomyelitis0self