Genes (80)
Species:
human : 80 | |
| Human | NOD2 | 64127 | nucleotide-binding oligomerization domain containing 2 | 3020insC mutation does not seem to influence the pathophysiology of periodontitis | | Human | SLC35C1 | 55343 | solute carrier family 35 (GDP-fucose transporter), member C1 | | | Human | KRT23 | 25984 | keratin 23 (histone deacetylase inducible) | Title:Single nucleotide polymorphisms associated with aggressive periodontitis and severe chronic periodontitis in Japanese.|Association:Y|Conclusion:These appear to be good candidates as genetic factors for future study. | | Human | FGL2 | 10875 | fibrinogen-like 2 | Title:Large-scale investigation of genomic markers for severe periodontitis.|Association:Y|Conclusion:These results suggest that SNPs in the GNRH1, PIK3R1, DPP4, FGL2, and CALCR genes are genomic markers for severe periodontitis. Our findings indicate the necessity of analyzing SNPs in genes on a large scale (i.e., genome-wide approach), to identify genomic markers for periodontitis. | | Human | TNFSF13B | 10673 | tumor necrosis factor (ligand) superfamily, member 13b | The known effect of B cells in periodontitis would be partly mediated by salivary BAFF in patients with primary Sjogren's syndrome | | Human | TNFSF11 | 8600 | tumor necrosis factor (ligand) superfamily, member 11 | Peripheral blood mononuclear cells from periodontitis patients did not require supplementation of M-CSF or M-CSF/RANKL for the formation of osteoclast-like cells; in controls, addition of these cytokines was needed compared the gene expression of RANKL and osteoprogerin in periodontitis and healthy subjects; data suggest up regulation of RANKL in inflammatory cells and epithelium may be associated with activation of osteoclastic bone destruction in periodontitis | | Human | AP3B1 | 8546 | adaptor-related protein complex 3, beta 1 subunit | Dental decay due to recurrent bacterial periodontitis | | Human | IL1R2 | 7850 | interleukin 1 receptor, type II | Title:Smoking and polymorphisms of the interleukin-1 gene cluster (IL-1alpha, IL-1beta, and IL-1RN) in patients with periodontal disease.|Association:Not Found|Conclusion:The results provide evidence that the composite genotypes studied show interaction with smoking, the main exposition-related risk factor of periodontal disease. Non-smoking subjects are not at increased risk, even if they are genotype-positive. | | Human | VDR | 7421 | vitamin D (1,25- dihydroxyvitamin D3) receptor | Title:Association of a vitamin D receptor gene polymorphism with localized early-onset periodontal diseases.|Association:Y|Conclusion:These data indicate that carriage of the less frequent allele of the Taq I RFLP (t) in the VDR gene significantly increases the risk of developing L-EOP. However, VDR genotype may not affect the incidence of all cases of EOP. These findings contribute to our understanding of the genetic basis for periodontal disease and may help define sub-groups of this disease which share common pathogenic factors. Vitamin D receptor Taq-I TT polymorphism was moderately associated with both the presence and the progression of periodontitis in smokers, while no association was detected in non-smoking individuals Title:Analysis of vitamin D and Fcgamma receptor polymorphisms in Japanese patients with generalized early-onset periodontitis.|Association:Y|Conclusion:In conclusion, no correlation was found between the VDR genotype and G-EOP. However, the VDR and Fc-gammaRIIIb genotype combination may be associated with susceptibility to G-EOP. Title:[Association of vitamin D receptor gene polymorphisms with the susceptibility to chronic periodontitis of Han nationality]|Association:Y|Conclusion:These data indicate that VDR ApaI allele A may be related to the susceptibility to CP in Han Nationality. | | Human | TNFRSF1B | 7133 | tumor necrosis factor receptor superfamily, member 1B | Title:Association of tumor necrosis factor receptor type 2 +587 gene polymorphism with severe chronic periodontitis.|Association:Not Found|Conclusion:These findings suggest that the TNFR2(+587G) polymorphic allele could be associated with severe CP in Japanese. | | Human | TNF | 7124 | tumor necrosis factor | Title:Association of the -159 CD14 gene polymorphism and lack of association of the -308 TNFA and Q551R IL-4RA polymorphisms with severe chronic periodontitis in Swedish Caucasians.|Association:Not Found|Conclusion:It is suggested that the -159 CD14 gene polymorphism is associated with chronic periodontitis in Caucasian subjects of a north European origin. Title:[Study on the Correlation of Cytokine Gene Polymorphism with Chronic Periodontitis]|Association:Y|Conclusion:IL-1B +3953 and TNF-A-308 allele 2 positive genotype have closer correlation with moderate-to-advanced AP. Genetic polymorphisms in the TNF-alpha gene at positions -376, -308, -238 and +489 could not be identified as susceptibility or severity factors in periodontitis Although the genetic background of TNFalpha could be shown to be associated with subgingival colonization with Prevotella intermedia, there is no evidence that it is an independent risk factor for periodontitis Discuss the role of AQP3 in TNF-alpha-mediated inflammation and the development of periodontitis | | Human | TLR4 | 7099 | toll-like receptor 4 | We found no evidence that the gene polymorphism of TLR4 (p = 1.000) and overall gene polymorphism in any of the genes (p = 0.752) correlate with periodontitis Title:Chronic periodontal disease is associated with single-nucleotide polymorphisms of the human TLR-4 gene|Association:Y|Conclusion:These data demonstrate that genetic variants of TLR-4 may act as risk factors for the development of generalized chronic periodontitis in humans. [prevalence of] Asp299Gly and Thr399Ile polymorphisms seemed to be rather low in the Chinese population, which did not permit any conclusion regarding its effects on periodontitis Title:CD14 and TLR4 Gene Polymorphisms in Adult Periodontitis.|Association:Not Found|Conclusion:We conclude that the CD14-260T/T genotype contributes to the susceptibility to severe periodontitis in Dutch Caucasians. | | Human | TLR2 | 7097 | toll-like receptor 2 | The TLR2- and TLR4-stimulating activity of supragingival plaque is associated with clinical parameters for gingivitis and periodontitis We found no evidence that the gene polymorphism of TLR2 (p = 1.000) and overall gene polymorphism in any of the genes (p = 0.752) correlate with periodontitis | | Human | TIMP2 | 7077 | TIMP metallopeptidase inhibitor 2 | Title:Analysis of the MMP-9 (C-1562 T) and TIMP-2 (G-418C) gene promoter polymorphisms in patients with chronic periodontitis.|Association:Not Found|Conclusion:The results show that the polymorphism in the promoter region of MMP-9 gene is not associated with chronic periodontitis. The high frequency of GG genotype in the TIMP-2 gene promoter in the population studied did not allow any conclusion regarding its effect on chronic periodontitis. | | Human | TGFB1 | 7040 | transforming growth factor, beta 1 | promoter may have a small effect on the modulation of the inflammatory process during periodontitis Title:Analysis of the TGF-beta1 promoter polymorphism (C-509T) in patients with chronic periodontitis.|Association:Y|Conclusion:These results demonstrate that the polymorphism at bp -509 in the TGF-beta1 promoter may have a small effect on the modulation of the inflammatory process during periodontitis. | | Human | RAGE | 5891 | | Title:Distribution of the receptor for advanced glycation end products gene polymorphisms in patients with chronic periodontitis: a preliminary study.|Association:Y|Conclusion:We can speculate that susceptibility to the development of chronic periodontitis could be influenced by the 1704G/T polymorphism of the RAGE gene, independently of diabetes. | | Human | PTGDS | 5730 | prostaglandin D2 synthase 21kDa (brain) | Title:Single nucleotide polymorphisms associated with aggressive periodontitis and severe chronic periodontitis in Japanese.|Association:Not Found|Conclusion:These appear to be good candidates as genetic factors for future study. | | Human | PRTN3 | 5657 | proteinase 3 | Neutrophil PR3 activates oral epithelial cells through G protein-coupled PAR-2 and actively participates in the process of inflammation such as periodontitis Neutrophil serine proteinase PR-3 activates human nonepithelial cells through protease-activated receptor 2 to produce inflammatory cytokines and may control a number of inflammatory processes such as periodontitis | | Human | PLG | 5340 | plasminogen | | | Human | PIK3R1 | 5295 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | Title:Large-scale investigation of genomic markers for severe periodontitis.|Association:Y|Conclusion:These results suggest that SNPs in the GNRH1, PIK3R1, DPP4, FGL2, and CALCR genes are genomic markers for severe periodontitis. Our findings indicate the necessity of analyzing SNPs in genes on a large scale (i.e., genome-wide approach), to identify genomic markers for periodontitis. | | Human | SERPINA1 | 5265 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | Title:Analysis of two common alpha 1-antitrypsin deficiency alleles (PI*Z and PI*S) in subjects with periodontitis.|Association:Not Found|Conclusion:We did not find evidence to support an association between mutant PI* alleles and periodontitis in a small, controlled study. Larger studies will be required to clarify the relationship between alpha1-antitrypsin genotype and susceptibility to inflammatory periodontal disease. | | Human | SERPINE1 | 5054 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | Title:Plasminogen-activator-inhibitor-1 promoter polymorphism as a risk factor for adult periodontitis in non-smokers.|Association:Y|Conclusion:An association was detected between the deletion (4G) allele (and 4G/4G genotype) and periodontitis (P = 0.0022, P(corr) < 0.01; P = 0.014, P(corr) < 0.05). A stronger association occurred in non-smokers (P = 0.00021, P(corr) < 0.01; P = 0.0024, P(corr) < 0.05) where the presence of the PAI-1 gene 4G allele appears to be one of the risk factors for periodontitis. | | Human | TNFRSF11B | 4982 | tumor necrosis factor receptor superfamily, member 11b | compared the gene expression of RANKL and osteoprogerin (OPG), a decoy receptor of RANKL, between moderate and advanced periodontitis, and healthy subjects | | Human | MPO | 4353 | myeloperoxidase | Peri-implant sulcus fluidfrom inflamed sites and gingival crevicular fluid from gingivitis and periodontitis sites presented higher total MPO levels than samples from noninflamed sites | | Human | MMP3 | 4314 | matrix metallopeptidase 3 (stromelysin 1, progelatinase) | polymorphisms do not influence susceptibility to periodontitis in Japanese patients |
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