Human | MIR133B | 442890 | microRNA 133b | role of miRNAs in mammalian midbrain dopaminergic neurons; study identified a miRNA, miR-133b, that is specifically expressed in midbrain dopaminergic neurons and is deficient in midbrain tissue from patients with Parkinson's disease |
Human | CDNF | 441549 | cerebral dopamine neurotrophic factor | expressed in several tissues; might be beneficial for the treatment of Parkinson's disease |
Human | HSP90AB2P | 391634 | heat shock protein 90kDa alpha (cytosolic), class B member 2, pseudogene | These data implicate predominantly Hsp90 in the formation of alpha-synuclein inclusions in Parkinson's disease and related alpha-synucleinopathies |
Human | STH | 246744 | saitohin | The R allele of STH is associated with the H2 haplotype of tau; no correlation is found between R allele frequency and Alzheimer's or Parkinson's disease |
Human | MTIF3 | 219402 | mitochondrial translational initiation factor 3 | the c.798C>T polymorphism of the MTIF3 gene showed allelic association with Parkinson's disease |
Human | PARK10 | 170534 | Parkinson disease 10 (susceptibility) | Single nucleotide polymorphisms strongly support HIVEP3 as a candidate for PARK10 in Parkinson disease |
Human | PACRG | 135138 | PARK2 co-regulated | PACRG is regulated by the ubiquitin-proteasomal system and may play a role in the pathogenesis of Parkinson's disease Glup/PACRG forms a large molecular chaperone complex, suppresses cell death induced by accumulation of unfolded Pael receptor, facilitates the formation of Pael-R inclusions,and is a component of Lewy bodies in Parkinson's disease |
Human | CD200R1 | 131450 | CD200 receptor 1 | Review highlights the close correlation between CD200-CD200 receptor (CD200R), microglia activation, and Parkinson's disease |
Human | LRRK2 | 120892 | leucine-rich repeat kinase 2 | Click here to display 90 evidence detail records. |
Human | GSTO2 | 119391 | glutathione S-transferase omega 2 | Title:Glutathione S-transferase omega-1 modifiesage-at-onset of Alzheimer disease and Parkinson disease.|Association:Not Found|Conclusion: |
Human | LRRK1 | 79705 | leucine-rich repeat kinase 1 | Two rare coding variants ss65713826 and ss65713830 were more frequent in patients than controls in norwegain Parkinson's disease |
Human | PINK1 | 65018 | PTEN induced putative kinase 1 | Click here to display 30 evidence detail records. |
Human | HS1BP3 | 64342 | HCLS1 binding protein 3 | HS1PB3 protein is mutated in essential tremor combined with Parkinson disease |
Human | C10orf2 | 56652 | chromosome 10 open reading frame 2 | This finding broadens the clinical spectrum of Twinkle gene mutations and further implicates loss of mitochondrial DNA integrity in the pathogenesis of Parkinson disease |
Human | USP40 | 55230 | ubiquitin specific peptidase 40 | Da suggest that genetic variants in USP40 affect the risk for late-onset Parkinson disease (PD), which is consistent with the predicted role of the ubiquitination pathway in PD etiology |
Human | WWOX | 51741 | WW domain containing oxidoreductase | Synthetic phospho-WOX1 peptide prevents neuronal death, suggesting its therapeutic role in mitigating the symptoms of Parkinson's disease |
Human | HTRA2 | 27429 | HtrA serine peptidase 2 | Polymorphism of OMI/HTRA2 previously shown to be associated with Parkinson's disease was present in the neurologically normal controls Point mutations in another mitochondrial protein, HtrA2, are a susceptibility factor for Parkinson disease (PARK13 locus) The study of HTRA2 to Parkinson disease risk in an extended series of 266 Belgian PD patients and 273 control individuals identified a novel p.Arg404Trp mutation within the PDZ domain predicted to freeze HTRA2 in an inactive form |
Human | RNF11 | 26994 | ring finger protein 11 | these findings identify RNF11 as a strong candidate gene at the PARK10 locus and highlight its potential significance in the development of the common form of Parkinson disease |
Human | FGF20 | 26281 | fibroblast growth factor 20 | Click here to display 5 evidence detail records. |
Human | GIGYF2 | 26058 | GRB10 interacting GYF protein 2 | Mutations in GIGYF2 are not strongly related to the development of the Parkinson's disease in Portuguese and North American populations These data strongly support GIGYF2 as a PARK11 gene with a causal role in familial Parkinson disease |
Human | RNF19A | 25897 | ring finger protein 19A, E3 ubiquitin protein ligase | results suggest that synphilin-1 has an important role in the formation of aggregates and cytotoxicity in Parkinson disease and that Dorfin may be involved in the pathogenic process by ubiquitylation of synphilin-1 |
Human | PRDX5 | 25824 | peroxiredoxin 5 | Our results show that mitochondrial PRDX-depleted cells are more prone to oxidative damages and apoptosis induced by MPP(+), a complex I inhibitor which provides an experimental paradigm of Parkinson's disease |
Human | ATP13A2 | 23400 | ATPase type 13A2 | Our data also suggest that ATP13A2 single heterozygous mutations might be etiologically relevant for patients with YOPD and further studies of this gene in Parkinson disease are warranted |
Human | USP24 | 23358 | ubiquitin specific peptidase 24 | Data suggest that genetic variants in USP24 affect the risk for late-onset Parkinson disease (PD), which is consistent with the predicted role of the ubiquitination pathway in PD etiology |
Human | SYT11 | 23208 | synaptotagmin XI | Lack of disease-causing mutations in a detailed analysis of a large sample of familial and sporadic Parkinson's disease patients argues against a major role of mutations in the synaptotagmin XI gene in PD |