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Details
Link-It Detail - Disease - Parkinson Disease
Debug Stats
  • ### Total Build Time: 181 ms 53.905 KB
  • CONCEPT_NAME gt=5 ms Completed: 5 ms rowSize= 332 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 383 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 188 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=5 ms Completed: 5 ms rowSize= 1,002 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=16 ms Completed: 16 ms rowSize= 4.102 KB
  • CONCEPT_RELATIONSHIPS gt=112 ms Completed: 112 ms rowSize= 15.244 KB
  • CONCEPT_GENES gt=42 ms Completed: 42 ms rowSize= 31.513 KB
  • CONCEPT_XREFS gt=1 ms Completed: 1 ms rowSize= 1.151 KB
  • CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Parkinson Disease C0030567
Definition (1)
progressive, degenerative disorder of the nervous system characterized by tremors, rigidity, bradykinesia, postural instability, and gait abnormalities; caused by a loss of neurons and a decrease of dopamine in the basal ganglia.
Semantic Types (1)
Disease or Syndrome (T047)
Parents (2)
img Parkinsonian Disorders C0242422
img Neurodegenerative Diseases C0524851
Ancestral Roots
RootRoot Plus OneDepthParent
img Nervous System Diseases C0027765img Central Nervous System Diseases C00076826img Parkinsonian Disorders C0242422
img Nervous System Diseases C0027765img Central Nervous System Diseases C00076825img Parkinsonian Disorders C0242422
img Nervous System Diseases C0027765img Neurodegenerative Diseases C05248513img Neurodegenerative Diseases C0524851
Relationships (365)

Relation Types:
diso_​to_​anat : 41
diso_​to_​chem : 163
diso_​to_​diso : 104
diso_​to_​gene : 14
diso_​to_​phen : 3
diso_​to_​phys : 40


Relationships:
none : 234
associated_​with : 2
clinically_​similar : 2
gene_​associated_​with_​disease : 12
gene_​product_​malfunction_​associated_​with_​disease : 3
is_​associated_​anatomic_​site_​of : 2
isa : 1
mapped_​to : 16
may_​treat : 88
related_​to : 5
Page Size
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Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_DISO2325img Complication Aspects C1171258
DISO_to_PHEN1729img genetic aspects C0017399
DISO_to_DISO1118img Complication Aspects C1171258
DISO_to_PHEN1046img genetic aspects C0017399
DISO_to_CHEM879img Antiparkinson Agents C0003405
DISO_to_CHEM808img Antiparkinson Agents C0003405
DISO_to_CHEM535img (-)-3-(3,4-Dihydroxyphenyl)-L-alanine C0023570
DISO_to_ANAT506img Structure of subthalamic nucleus C0152355
DISO_to_CHEM503img (-)-3-(3,4-Dihydroxyphenyl)-L-alanine C0023570
DISO_to_ANAT469img Brain C0006104
DISO_to_ANAT425img Structure of subthalamic nucleus C0152355
DISO_to_CHEM416img alpha-Synuclein C0285890
DISO_to_DISO399img Cognition Disorders C0009241
DISO_to_ANAT386img Neurons C0027882
DISO_to_CHEM383img Dopamine C0013030
DISO_to_ANAT348img Brain C0006104
DISO_to_PHYS339img GENET PREDISPOSITION C0314657
DISO_to_CHEM304img Protein-Serine-Threonine Kinases C0072402
DISO_to_CHEM295img Dopamine C0013030
DISO_to_CHEM284img Nerve Tissue Proteins C0027759
DISO_to_DISO279img Dementia C0497327
DISO_to_ANAT268img Substantia Nigra C0038590
DISO_to_CHEM263img Dopamine Agonists C0178601
DISO_to_ANAT239img Neurons C0027882
DISO_to_CHEM232img Dopamine Agonists C0178601
Genes (183)

Species:
human : 183
Page Size
Current 25
  Page 1 of 8
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Current 1
SpeciesGeneGeneIdGene NameEvidence
HumanMIR133B442890microRNA 133b
img GENERIF, Score=1000, Pubmed Id: 17761882, UMLKSK CUI: C0030567
HumanCDNF441549cerebral dopamine neurotrophic factor
img GENERIF, Score=1000, Pubmed Id: 17611540, UMLKSK CUI: C0030567
HumanHSP90AB2P391634heat shock protein 90kDa alpha (cytosolic), class B member 2, pseudogene
img GENERIF, Score=1000, Pubmed Id: 16507910, UMLKSK CUI: C0030567
HumanSTH246744saitohin
img GENERIF, Score=1000, Pubmed Id: 12932819, UMLKSK CUI: C0030567
HumanMTIF3219402mitochondrial translational initiation factor 3
img GENERIF, Score=1000, Pubmed Id: 17267121, UMLKSK CUI: C0030567
HumanPARK10170534Parkinson disease 10 (susceptibility)
img GENERIF, Score=1000, Pubmed Id: 17388942, UMLKSK CUI: C0030567
HumanPACRG135138PARK2 co-regulated
img GENERIF, Score=1000, Pubmed Id: 17590346, UMLKSK CUI: C0030567
img GENERIF, Score=1000, Pubmed Id: 14532270, UMLKSK CUI: C0030567
HumanCD200R1131450CD200 receptor 1
img GENERIF, Score=1000, Pubmed Id: 18040859, UMLKSK CUI: C0030567
HumanLRRK2120892leucine-rich repeat kinase 2
Click here to display 90 evidence detail records.
HumanGSTO2119391glutathione S-transferase omega 2
img GAD, Score=1000, Pubmed Id: 14570706, UMLKSK CUI: C0030567
HumanLRRK179705leucine-rich repeat kinase 1
img GENERIF, Score=901, Pubmed Id: 17324517, UMLKSK CUI: C0030567
HumanPINK165018PTEN induced putative kinase 1
Click here to display 30 evidence detail records.
HumanHS1BP364342HCLS1 binding protein 3
img GENERIF, Score=1000, Pubmed Id: 16116142, UMLKSK CUI: C0030567
HumanC10orf256652chromosome 10 open reading frame 2
img GENERIF, Score=1000, Pubmed Id: 17620490, UMLKSK CUI: C0030567
HumanUSP4055230ubiquitin specific peptidase 40
img GENERIF, Score=861, Pubmed Id: 16917932, UMLKSK CUI: C0030567
HumanWWOX51741WW domain containing oxidoreductase
img GENERIF, Score=1000, Pubmed Id: 18371080, UMLKSK CUI: C0030567
HumanHTRA227429HtrA serine peptidase 2
img GENERIF, Score=1000, Pubmed Id: 18364387, UMLKSK CUI: C0030567
img GENERIF, Score=1000, Pubmed Id: 19076428, UMLKSK CUI: C0030567
img GENERIF, Score=734, Pubmed Id: 18401856, UMLKSK CUI: C0030567
HumanRNF1126994ring finger protein 11
img GENERIF, Score=1000, Pubmed Id: 17917589, UMLKSK CUI: C0030567
HumanFGF2026281fibroblast growth factor 20
Click here to display 5 evidence detail records.
HumanGIGYF226058GRB10 interacting GYF protein 2
img GENERIF, Score=1000, Pubmed Id: 18923002, UMLKSK CUI: C0030567
img GENERIF, Score=901, Pubmed Id: 18358451, UMLKSK CUI: C0030567
HumanRNF19A25897ring finger protein 19A, E3 ubiquitin protein ligase
img GENERIF, Score=1000, Pubmed Id: 12750386, UMLKSK CUI: C0030567
HumanPRDX525824peroxiredoxin 5
img GENERIF, Score=1000, Pubmed Id: 18262354, UMLKSK CUI: C0030567
HumanATP13A223400ATPase type 13A2
img GENERIF, Score=1000, Pubmed Id: 17485642, UMLKSK CUI: C0030567
HumanUSP2423358ubiquitin specific peptidase 24
img GENERIF, Score=861, Pubmed Id: 16917932, UMLKSK CUI: C0030567
HumanSYT1123208synaptotagmin XI
img GENERIF, Score=694, Pubmed Id: 15354386, UMLKSK CUI: C0030567
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0030567Parkinson Disease0self