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Details
Link-It Detail - Disease - Osteonecrosis
Debug Stats
  • ### Total Build Time: 218 ms 56.405 KB
  • CONCEPT_NAME gt=10 ms Completed: 10 ms rowSize= 367 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 224 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 188 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=15 ms Completed: 15 ms rowSize= 975 bytes
  • CONCEPT_CHILDREN gt=10 ms Completed: 10 ms rowSize= 557 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=9 ms Completed: 9 ms rowSize= 2.782 KB
  • CONCEPT_RELATIONSHIPS gt=131 ms Completed: 131 ms rowSize= 13.106 KB
  • CONCEPT_GENES gt=39 ms Completed: 39 ms rowSize= 37.085 KB
  • CONCEPT_XREFS gt=3 ms Completed: 3 ms rowSize= 1.147 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Disease (2)
Osteonecrosis C0029445
Bone necrosis
Definition (1)
death of a bone or part of a bone, either atraumatic or posttraumatic.
Semantic Types (1)
Pathologic Function (T046)
Parents (2)
img Bone Diseases C0005940
img Necrosis C0027540
Children (1)
img Femur Head Necrosis C0015814
Ancestral Roots
RootRoot Plus OneDepthParent
img Musculoskeletal Diseases C0026857img Bone Diseases C00059403img Bone Diseases C0005940
img Pathological Conditions, Signs and Symptoms C0039058img Pathologic Processes C00306604img Necrosis C0027540
Relationships (72)

Relation Types:
diso_​to_​anat : 20
diso_​to_​chem : 12
diso_​to_​diso : 39
diso_​to_​phen : 1


Relationships:
none : 56
is_​associated_​anatomic_​site_​of : 1
is_​primary_​anatomic_​site_​of_​disease : 1
isa : 8
mapped_​to : 5
related_​to : 1
Page Size
Current 25
  Page 1 of 3
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_DISO771img chemically induced C0007994
DISO_to_CHEM610img Diphosphonates C0012544
DISO_to_DISO541img Disease of jaw C0022362
DISO_to_CHEM483img Bone Density Conservation Agents C1563726
DISO_to_DISO267img chemically induced C0007994
DISO_to_CHEM204img Diphosphonates C0012544
DISO_to_DISO137img Disease of jaw C0022362
DISO_to_CHEM136img Bone Density Conservation Agents C1563726
DISO_to_DISO96img Complication Aspects C1171258
DISO_to_DISO87img Disease, Mandibular C0024689
DISO_to_CHEM76img Imidazoles C0020924
DISO_to_DISO70img Complication Aspects C1171258
DISO_to_ANAT64img Lunate Bone C0036624
DISO_to_ANAT51img Jaw C0022359
DISO_to_DISO40img Disease, Mandibular C0024689
DISO_to_ANAT39img Knee Joint C0022745
DISO_to_DISO39img Multiple Myeloma C0026764
DISO_to_DISO38img Disease, Maxillary C0024950
DISO_to_ANAT37img Bone structure of radius C0034627
DISO_to_ANAT37img Femur C0015811
DISO_to_DISO34img Osteoporosis C0029456
DISO_to_CHEM33img Imidazoles C0020924
DISO_to_DISO33img HIV Infections C0019693
DISO_to_ANAT32img Knee Joint C0022745
DISO_to_ANAT32img Scaphoid Bone C0223724
Genes (27)

Species:
human : 27
Page Size
Current 25
  Page 1 of 2
Prior Page
Current 1
SpeciesGeneGeneIdGene NameEvidence
HumanIL23R149233interleukin 23 receptor
img GENERIF, Score=1000, Pubmed Id: 18779654, UMLKSK CUI: C0029445
HumanKL9365klotho
img GENERIF, Score=827, Pubmed Id: 15784727, UMLKSK CUI: C0029445
HumanVDR7421vitamin D (1,25- dihydroxyvitamin D3) receptor
img GAD, Score=1000, Pubmed Id: 15459215, UMLKSK CUI: C0029445
HumanTYMS7298thymidylate synthetase
img GAD, Score=1000, Pubmed Id: 15459215, UMLKSK CUI: C0029445
HumanTRPS17227trichorhinophalangeal syndrome I
INFERRED, Score=800, UMLKSK CUI: C0029445
HumanTP537157tumor protein p53
img GENERIF, Score=861, Pubmed Id: 18979157, UMLKSK CUI: C0029445
HumanSREBF16720sterol regulatory element binding transcription factor 1
img GENERIF, Score=1000, Pubmed Id: 19040658, UMLKSK CUI: C0029445
HumanPPARG5468peroxisome proliferator-activated receptor gamma
img GENERIF, Score=1000, Pubmed Id: 18182855, UMLKSK CUI: C0029445
HumanPON15444paraoxonase 1
img GENERIF, Score=1000, Pubmed Id: 17469180, UMLKSK CUI: C0029445
HumanABCB15243ATP-binding cassette, sub-family B (MDR/TAP), member 1
img GENERIF, Score=827, Pubmed Id: 18696186, UMLKSK CUI: C0029445
img GENERIF, Score=1000, Pubmed Id: 14583680, UMLKSK CUI: C0029445
HumanSERPINE15054serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
img GENERIF, Score=861, Pubmed Id: 12438962, UMLKSK CUI: C0029445
img GAD, Score=1000, Pubmed Id: 14742985, UMLKSK CUI: C0029445
img GENERIF, Score=1000, Pubmed Id: 18285546, UMLKSK CUI: C0029445
img GAD, Score=833, Pubmed Id: 12438962, UMLKSK CUI: C0029445
HumanNOS34846nitric oxide synthase 3 (endothelial cell)
img GENERIF, Score=861, Pubmed Id: 18829920, UMLKSK CUI: C0029445
img GENERIF, Score=812, Pubmed Id: 16779830, UMLKSK CUI: C0029445
img GENERIF, Score=861, Pubmed Id: 17974890, UMLKSK CUI: C0029445
HumanMTHFR4524methylenetetrahydrofolate reductase (NAD(P)H)
img GAD, Score=1000, Pubmed Id: 14742985, UMLKSK CUI: C0029445
img GENERIF, Score=861, Pubmed Id: 11801474, UMLKSK CUI: C0029445
img GENERIF, Score=1000, Pubmed Id: 16549163, UMLKSK CUI: C0029445
HumanIL17A3605interleukin 17A
img GENERIF, Score=1000, Pubmed Id: 18585926, UMLKSK CUI: C0029445
HumanHIF1A3091hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
img GENERIF, Score=1000, Pubmed Id: 17292638, UMLKSK CUI: C0029445
HumanGBA2629glucosidase, beta, acid
img OMIM, Score=1000, UMLKSK CUI: C0029445
HumanFGB2244fibrinogen beta chain
INFERRED, Score=800, UMLKSK CUI: C0029445
HumanF52153coagulation factor V (proaccelerin, labile factor)
img GENERIF, Score=1000, Pubmed Id: 16549163, UMLKSK CUI: C0029445
img GENERIF, Score=1000, Pubmed Id: 15723247, UMLKSK CUI: C0029445
HumanEXT12131exostosin glycosyltransferase 1
INFERRED, Score=800, UMLKSK CUI: C0029445
HumanCYP2C81558cytochrome P450, family 2, subfamily C, polypeptide 8
img GENERIF, Score=861, Pubmed Id: 18594024, UMLKSK CUI: C0029445
HumanCTNNB11499catenin (cadherin-associated protein), beta 1, 88kDa
img GENERIF, Score=827, Pubmed Id: 18288545, UMLKSK CUI: C0029445
HumanCREBBP1387CREB binding protein
img GENERIF, Score=827, Pubmed Id: 17704997, UMLKSK CUI: C0029445
img GENERIF, Score=827, Pubmed Id: 18696186, UMLKSK CUI: C0029445
HumanCOL2A11280collagen, type II, alpha 1
INFERRED, Score=800, UMLKSK CUI: C0029445
HumanBMP6654bone morphogenetic protein 6
img GENERIF, Score=827, Pubmed Id: 15784727, UMLKSK CUI: C0029445
HumanANXA2302annexin A2
img GAD, Score=1000, Pubmed Id: 15784727, UMLKSK CUI: C0029445
img GENERIF, Score=827, Pubmed Id: 15784727, UMLKSK CUI: C0029445
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0029445Osteonecrosis0self