Human | TNF | 7124 | tumor necrosis factor | Title:Association between genetic polymorphism of tumor necrosis factor-alpha and risk of oral submucous fibrosis, a pre-cancerous condition of oral cancer.|Association:Not Found|Conclusion:The finding may imply a multifunctional etiological factor of TNF-alpha in OSF pathogenesis. |
Human | TGFB1 | 7040 | transforming growth factor, beta 1 | Title:Interaction of collagen-related genes and susceptibility to betel quid-induced oral submucous fibrosis.|Association:Not Found|Conclusion:These results imply that susceptibility to OSF could involve multigenic mechanisms modified by the betel quid-exposure dose |
Human | MMP8 | 4317 | matrix metallopeptidase 8 (neutrophil collagenase) | Title:Interaction of collagen-related genes and susceptibility to betel quid-induced oral submucous fibrosis.|Association:Not Found|Conclusion:These results imply that susceptibility to OSF could involve multigenic mechanisms modified by the betel quid-exposure dose |
Human | LTA | 4049 | lymphotoxin alpha | Title:Association between genetic polymorphism of tumor necrosis factor-alpha and risk of oral submucous fibrosis, a pre-cancerous condition of oral cancer.|Association:Y|Conclusion:The finding may imply a multifunctional etiological factor of TNF-alpha in OSF pathogenesis. |
Human | LOX | 4015 | lysyl oxidase | Title:Interaction of collagen-related genes and susceptibility to betel quid-induced oral submucous fibrosis.|Association:Not Found|Conclusion:These results imply that susceptibility to OSF could involve multigenic mechanisms modified by the betel quid-exposure dose |
Human | HLA-DRB1 | 3123 | | Title:HLA typing in Taiwanese patients with oral submucous fibrosis.|Association:Not Found|Conclusion:We conclude that some Taiwanese areca quid (AQ) chewers with particular HLA phenotypes and haplotypes are prone to have OSF. In addition, some particular HLA haplotypes may play more important roles than the individual HLA phenotypes for the genetic susceptibility to OSF. However, the significantly increased HLA phenotype B76 and three of the common HLA haplotypes detected are present in only about 20% of incident cases of OSF. |
Human | HLA-DQB1 | 3119 | | Title:HLA typing in Taiwanese patients with oral submucous fibrosis.|Association:Not Found|Conclusion:We conclude that some Taiwanese areca quid (AQ) chewers with particular HLA phenotypes and haplotypes are prone to have OSF. In addition, some particular HLA haplotypes may play more important roles than the individual HLA phenotypes for the genetic susceptibility to OSF. However, the significantly increased HLA phenotype B76 and three of the common HLA haplotypes detected are present in only about 20% of incident cases of OSF. |
Human | HLA-C | 3107 | | Title:HLA typing in Taiwanese patients with oral submucous fibrosis.|Association:Not Found|Conclusion:We conclude that some Taiwanese areca quid (AQ) chewers with particular HLA phenotypes and haplotypes are prone to have OSF. In addition, some particular HLA haplotypes may play more important roles than the individual HLA phenotypes for the genetic susceptibility to OSF. However, the significantly increased HLA phenotype B76 and three of the common HLA haplotypes detected are present in only about 20% of incident cases of OSF. |
Human | HLA-B | 3106 | | Title:HLA typing in Taiwanese patients with oral submucous fibrosis.|Association:Not Found|Conclusion:We conclude that some Taiwanese areca quid (AQ) chewers with particular HLA phenotypes and haplotypes are prone to have OSF. In addition, some particular HLA haplotypes may play more important roles than the individual HLA phenotypes for the genetic susceptibility to OSF. However, the significantly increased HLA phenotype B76 and three of the common HLA haplotypes detected are present in only about 20% of incident cases of OSF. |
Human | HLA-A | 3105 | | Title:HLA typing in Taiwanese patients with oral submucous fibrosis.|Association:Not Found|Conclusion:We conclude that some Taiwanese areca quid (AQ) chewers with particular HLA phenotypes and haplotypes are prone to have OSF. In addition, some particular HLA haplotypes may play more important roles than the individual HLA phenotypes for the genetic susceptibility to OSF. However, the significantly increased HLA phenotype B76 and three of the common HLA haplotypes detected are present in only about 20% of incident cases of OSF. |
Human | HIF1A | 3091 | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | may play a role in malignant transformation of oral submucous fibrosis |
Human | GSTT1 | 2952 | glutathione S-transferase theta 1 | there is no significant difference in the allelic variants in GSTM1 between oral submucous fibrosis and normal, while GSTT1 null gene showed significantly higher frequencies in this precancerous condition |
Human | GSTM1 | 2944 | glutathione S-transferase mu 1 | there is no significant difference in the allelic variants in GSTM1 between oral submucous fibrosis and normal, while GSTT1 null gene showed significantly higher frequencies in this precancerous condition |
Human | FGF2 | 2247 | fibroblast growth factor 2 (basic) | bFGF immunoreactivity was found to be increased in fibroblasts and in endothelial cells in early oral submucous fibrosis cases, while the expression of bFGF in stroma increased notably in advanced fibrosis |
Human | CTLA4 | 1493 | cytotoxic T-lymphocyte-associated protein 4 | Title:Association of CTLA-4 gene polymorphism with oral submucous fibrosis in Taiwan.|Association:Y|Conclusion:This is the first report that the CTLA-4 +49 G allele confers an increased risk of OSF in Taiwan. |
Human | CST3 | 1471 | cystatin C | Title:Interaction of collagen-related genes and susceptibility to betel quid-induced oral submucous fibrosis.|Association:Not Found|Conclusion:These results imply that susceptibility to OSF could involve multigenic mechanisms modified by the betel quid-exposure dose |
Human | COL1A2 | 1278 | collagen, type I, alpha 2 | Title:Interaction of collagen-related genes and susceptibility to betel quid-induced oral submucous fibrosis.|Association:Not Found|Conclusion:These results imply that susceptibility to OSF could involve multigenic mechanisms modified by the betel quid-exposure dose |
Human | COL1A1 | 1277 | collagen, type I, alpha 1 | Title:Interaction of collagen-related genes and susceptibility to betel quid-induced oral submucous fibrosis.|Association:Not Found|Conclusion:These results imply that susceptibility to OSF could involve multigenic mechanisms modified by the betel quid-exposure dose |
Human | BIRC5 | 332 | baculoviral IAP repeat containing 5 | the phosphorylation of survivin on Thr34 critically regulate survivin and plays an important role during the malignant transformation of oral submucous fibrosis |