Human | FTO | 79068 | fat mass and obesity associated | This study suggests that FTO may have an important role for gender specific development of severe obesity and insulin resistance in children Increased BMI in morbid obesity is associated with a combination of FTO and INSIG2 SNPs |
Human | INSIG2 | 51141 | insulin induced gene 2 | rs7566605 in the upstream region of the INSIG2 gene was found to be associated with obesity, i.e., severe obesity, in Japanese |
Human | MFN2 | 9927 | mitofusin 2 | the significant increase in mitofusin 2 mRNA levels may explain the increase in glucose oxidation observed in morbid obesity |
Human | ADIPOQ | 9370 | adiponectin, C1Q and collagen domain containing | adiponectin DNA sequence variations might play a role in the complications of morbid obesity |
Human | IRS2 | 8660 | insulin receptor substrate 2 | Mutations in IRS2 gene are associated with severe obesity |
Human | TNF | 7124 | tumor necrosis factor | obese women, even those with morbid obesity, over-express TNFalpha in subcutaneous adipose tissue in proportion to the magnitude of the fat depot |
Human | TGFB1 | 7040 | transforming growth factor, beta 1 | The release of TGF-beta1 in morbid obesity was primarily by the nonfat cells of human adipose tissue because release by adipocytes was less than 10% of that by the nonfat cells of adipose tissue |
Human | SIM1 | 6492 | single-minded homolog 1 (Drosophila) | Haploinsufficiency of the SIM1 gene might be responsible for the severe obesity observed in a child with a Prader-Willi-like phenotype |
Human | PPARG | 5468 | peroxisome proliferator-activated receptor gamma | The Pro115Gln polymorphism has no epidemiological impact on morbid obesity |
Human | POMC | 5443 | proopiomelanocortin | We and others have identified several single gene defects that disrupt the molecules in the leptin-melanocortin pathway causing severe obesity in humans |
Human | SERPINE1 | 5054 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | A decrease in body mass index in severe and morbid obesity shows a favourable effect on the fibrinolytic system due to a decrease in plasminogen activator inhibitor type 1 levels, but no influence of 4G/5G polymorphism has been observed |
Human | NTRK2 | 4915 | neurotrophic tyrosine kinase, receptor, type 2 | An 8-year-old male with a complex developmental syndrome and severe obesity was heterozygous for a de novo missense mutation resulting in a Y722C substitution in the neurotrophin receptor TrkB |
Human | MC4R | 4160 | melanocortin 4 receptor | Genetic variation in the transcriptionally essential region of the MC4R promoter is not a significant cause of severe obesity in humans |
Human | MC3R | 4159 | melanocortin 3 receptor | A novel melanocortin 3 receptor gene (MC3R) mutation associated with severe obesity |
Human | LEP | 3952 | leptin | in morbid obesity, there appears to be an association between serum concentrations of leptin and a more favorable lipid profile, whereas there is no direct interrelation between serum concentrations of cholesterol and dehydroepiandrosterone sulfate |
Human | GCG | 2641 | glucagon | In morbid obesity, accelerated inactivation of circulating GLP-1 could at least partially account for plasma peptide levels lower than normal, defective availability of such a satiety factor possibly contributing to eating behaviour abnormalities |
Human | ESR2 | 2100 | estrogen receptor 2 (ER beta) | A minor importance of ESR2 on severe obesity cannot be excluded |
Human | ACE | 1636 | angiotensin I converting enzyme | Not associated with severe obesity |
Human | BDNF | 627 | brain-derived neurotrophic factor | A de novo chromosomal inversion, 46,XX,inv(11)(p13p15.3) caused hyperphagia and severe obesity, impaired cognitive function, and hyperactivity in a young girl |
Human | AQP7 | 364 | aquaporin 7 | increased gene expression in visceral adipose tissue and liver in morbid obesity |
Human | ADRB1 | 153 | adrenoceptor beta 1 | Genetic variations of ADRB1 in relationship to morbid obesity and suggests mutations in the BAR-1 coding sequence is not likely a major cause of morbid obesity at least in Japanese |