Genes (81)
Species: human : 79 mouse : 2 | |
Mouse | PRKAR1A | 5573 | protein kinase, cAMP-dependent, regulatory, type I, alpha | Similarly, tissue-specific ablation of Prkar1a from a subset of facial neural crest cells caused the formation of schwannomas with divergent differentiation. | Mouse | NF2 | 4771 | neurofibromin 2 (merlin) | Mouse embryonic fibroblast (MEF/3T3) and rat schwannoma (RT4) cell lines were generated to provide regulatable schwannomin expression. | Human | PTPRVP | 148713 | protein tyrosine phosphatase, receptor type, V, pseudogene | INFERRED, Score=800, UMLKSK CUI: C0027809 | Human | MAGED4B | 81557 | melanoma antigen family D, 4B | The five markers tested were negative in all but two schwannomas, one with focal melanocyte-specific transcription factor and the other with tyrosinase and weak MAGE-1 reactivity. | Human | CXCL16 | 58191 | chemokine (C-X-C motif) ligand 16 | CXCL16 appears to be a novel growth factor for schwannomas of different localization | Human | AKR1B10 | 57016 | aldo-keto reductase family 1, member B10 (aldose reductase) | METHODS: Rat Schwannoma cells were cultured in 5.5 or 20 mM glucose in the presence or absence of an aldose reductase inhibitor, epalrestat (1 microM) for 14 days. | Human | SOX6 | 55553 | SRY (sex determining region Y)-box 6 | In contrast, ependymal tumors (ependymoma and subependymoma), meningioma, and schwannoma, which are all well differentiated tumors, showed either no staining or only faint staining for SOX6. | Human | SPA17 | 53340 | sperm autoantigenic protein 17 | METHODS : The expression of Sp17 was assessed by means of a standardised immunohistochemical procedure [(mAb/antigen) MF1/Sp17] in formalin-fixed and paraffin embedded surgical specimens of NS malignancies, including 28 neuroectodermal primary tumours (6 astrocytomas, 16 glioblastoma multiforme, 5 oligodendrogliomas, and 1 ependymoma), 25 meningeal tumours, and five peripheral nerve sheath tumours (4 schwannomas, and 1 neurofibroma),. | Human | IL23A | 51561 | interleukin 23, alpha subunit p19 | INFERRED, Score=800, UMLKSK CUI: C0027809 | Human | ANGPT4 | 51378 | angiopoietin 4 | Results describe the expression of angiopoietin-1, 2 and 4 and Tie-1 and 2 in gastrointestinal stromal tumors, leiomyomas and schwannomas | Human | EPB41L3 | 23136 | erythrocyte membrane protein band 4.1-like 3 | In this report, we demonstrate that DAL-1 suppresses cell proliferation in meningioma, but not schwannoma cells. | Human | RASSF1 | 11186 | Ras association (RalGDS/AF-6) domain family member 1 | INFERRED, Score=800, UMLKSK CUI: C0027809 | Human | PSIP1 | 11168 | PC4 and SFRS1 interacting protein 1 | We investigated the function of p75-mediated NF-kappaB stimulation in regulating cell survival in the rat schwannoma cell line RN22, which expresses p75, but not TrkA. | Human | NES | 10763 | nestin | In this study we immunohistochemically examined the expression of nestin and other intermediate filament proteins, including desmin, keratins (Ks), glial fibrillary acidic protein (GFAP), neurofilament, and vimentin in GISTs of different sites, esophageal leiomyomas and GI schwannomas. Nestin is confirmed to be consistently expressed in GISTs but it is also present in most GI schwannomas; GFAP is helpful when separating GISTs and schwannomas, since only the latter are positive. In contrast, three leiomyomas and a schwannoma that developed in the gastrointestinal tract showed no apparent immunoreactivity for nestin. Patterns of nestin and other intermediate filament expression distinguish between gastrointestinal stromal tumors, leiomyomas and schwannomas. | Human | CXCR6 | 10663 | chemokine (C-X-C motif) receptor 6 | Expression of the CXCL16-CXCR6-system in human schwannomas of different localization and in malignant peripheral nerve sheath tumors | Human | MVP | 9961 | major vault protein | Expression of MVP/LRP was observed in 81.2% (56/69) of primary nervous system tumors, including astrocytomas (11/13), oligodendrogliomas (1/2), oligoastrocytomas (5/5), ependymoma (1/1), meningiomas (35/45), schwannomas (2/2), and neurofibroma (1/1). | Human | NRG2 | 9542 | neuregulin 2 | These observations suggest that autocrine, paracrine, and/or juxtacrine NRG-1/NRG-2 signaling promotes schwannoma pathogenesis and that this signaling pathway may be an important therapeutic target in schwannomas. | Human | HGS | 9146 | hepatocyte growth factor-regulated tyrosine kinase substrate | HRS inhibits Stat3 activation in schwannoma cells | Human | SART1 | 9092 | squamous cell carcinoma antigen recognized by T cells | The SART1(259) antigen was detected in the cytosol fraction of 13 of 18 (72%) glioma cell lines and in 12 of 34 (35%) brain-tumor tissues, with a higher rate of expression among malignant gliomas (5/10, 50%) and schwannomas (3/4). | Human | TNFRSF6B | 8771 | tumor necrosis factor receptor superfamily, member 6b, decoy | This study surveys the connexin(s) expressed by rat sciatic nerve, cultured Schwann cells, and a mouse Schwannoma (TR6 Bc1) cell line. | Human | SCG2 | 7857 | secretogranin II | INFERRED, Score=800, UMLKSK CUI: C0027809 | Human | WT2 | 7491 | Wilms tumor 2 | INFERRED, Score=800, UMLKSK CUI: C0027809 | Human | EZR | 7430 | ezrin | These data indicate that the specific loss of merlin is universal to schwannomas and is not linked to loss of ezrin, radixin, or moesin expression. We therefore studied expression of NF2-encoded merlin as well as ezrin, radixin, and moesin in 22 vestibular and peripheral schwannomas that had been evaluated for NF2 mutations and chromosome 22q loss. Western blotting with antibodies directed against ezrin, radixin, and moesin, however, showed expression of these proteins in all schwannomas. The gene for NF2, a syndrome typically associated with vestibular schwannomas and meningiomas, is homologous with a family of genes whose members appear to play an important role in bridging the cell membrane with the intracellular cytoskeleton, including moesin, ezrin, radixin, and protein 4.1. The neurofibromatosis 2 protein product merlin, named for its relatedness to the ezrin, radixin and moesin (ERM) family of proteins, is a tumour suppressor whose absence results in the occurrence of multiple tumours of the nervous system, particularly schwannomas and meningiomas. Levels of ezrin and moesin, proteins related to the NF2 gene product, merlin, were unchanged in schwannoma cells compared to NHSC. | Human | VEGFA | 7422 | vascular endothelial growth factor A | High VEGF expression is associated with intracranial schwannomas | Human | TP53 | 7157 | tumor protein p53 | INFERRED, Score=800, UMLKSK CUI: C0027809 |
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