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Details
Link-It Detail - Disease - Nerve Degeneration
Debug Stats
  • ### Total Build Time: 55 ms 54.413 KB
  • CONCEPT_NAME gt=0 Completed: 0 ms rowSize= 383 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 576 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 198 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 556 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 1.416 KB
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 1.530 KB
  • CONCEPT_RELATIONSHIPS gt=1 ms Completed: 1 ms rowSize= 13.404 KB
  • CONCEPT_GENES gt=53 ms Completed: 53 ms rowSize= 35.210 KB
  • CONCEPT_XREFS gt=1 ms Completed: 1 ms rowSize= 1.152 KB
  • CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
  • Reload Stats
Disease (2)
Nerve Degeneration C0027746
Degeneration, Nerve
Definition (1)
Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
Semantic Types (1)
Cell or Molecular Dysfunction (T049)
Parents (1)
img Pathologic Processes C0030660
Children (3)
img Subacute Combined Degeneration C0221065
img Retrograde Degeneration C0035354
img Wallerian Degeneration C0043020
Ancestral Roots
RootRoot Plus OneDepthParent
img Pathological Conditions, Signs and Symptoms C0039058img Pathologic Processes C00306603img Pathologic Processes C0030660
Relationships (209)

Relation Types:
diso_​to_​anat : 50
diso_​to_​chem : 61
diso_​to_​diso : 74
diso_​to_​phen : 2
diso_​to_​phys : 22


Relationships:
none : 205
mapped_​to : 1
permuted_​term_​of : 1
use : 2
Page Size
Current 25
  Page 1 of 9
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_ANAT397img Neurons C0027882
DISO_to_PHEN388img genetic aspects C0017399
DISO_to_DISO350img chemically induced C0007994
DISO_to_ANAT332img Neurons C0027882
DISO_to_DISO315img chemically induced C0007994
DISO_to_PHEN276img genetic aspects C0017399
DISO_to_ANAT223img Brain C0006104
DISO_to_CHEM183img Agents, Neuroprotective C0242912
DISO_to_ANAT170img Brain C0006104
DISO_to_DISO165img Alzheimer Disease C0002395
DISO_to_ANAT150img Hippocampus C0019564
DISO_to_CHEM135img Agents, Neuroprotective C0242912
DISO_to_PHYS135img Apoptosis C0162638
DISO_to_ANAT132img Hippocampus C0019564
DISO_to_PHYS132img Apoptosis C0162638
DISO_to_DISO119img Alzheimer Disease C0002395
DISO_to_ANAT115img Axon C0004461
DISO_to_DISO114img Parkinson Disease C0030567
DISO_to_DISO113img Oxidative Stress C0242606
DISO_to_ANAT96img Motor Neurons C0026609
DISO_to_CHEM93img Dopamine C0013030
DISO_to_ANAT88img Substantia Nigra C0038590
DISO_to_PHYS88img Aging C0001811
DISO_to_DISO87img Amyotrophic Lateral Sclerosis C0002736
DISO_to_DISO85img Brain Ischemia C0007786
Genes (89)

Species:
human : 89
Page Size
Current 25
  Page 1 of 4
Prior Page
Current 1
SpeciesGeneGeneIdGene NameEvidence
HumanLOC643387643387TAR DNA binding protein pseudogene
img GENERIF, Score=901, Pubmed Id: 17469116, UMLKSK CUI: C0027746
HumanPPARGC1B133522peroxisome proliferator-activated receptor gamma, coactivator 1 beta
img GENERIF, Score=1000, Pubmed Id: 17018837, UMLKSK CUI: C0027746
HumanLRRK2120892leucine-rich repeat kinase 2
img GENERIF, Score=1000, Pubmed Id: 17440812, UMLKSK CUI: C0027746
img GENERIF, Score=964, Pubmed Id: 18539535, UMLKSK CUI: C0027746
img GENERIF, Score=1000, Pubmed Id: 15680456, UMLKSK CUI: C0027746
HumanPANK280025pantothenate kinase 2
img GENERIF, Score=1000, Pubmed Id: 17631502, UMLKSK CUI: C0027746
img GENERIF, Score=827, Pubmed Id: 16450344, UMLKSK CUI: C0027746
img GENERIF, Score=1000, Pubmed Id: 15659606, UMLKSK CUI: C0027746
img GENERIF, Score=694, Pubmed Id: 15465096, UMLKSK CUI: C0027746
HumanPANK379646pantothenate kinase 3
img GENERIF, Score=1000, Pubmed Id: 17631502, UMLKSK CUI: C0027746
HumanTDP155775tyrosyl-DNA phosphodiesterase 1
img GENERIF, Score=694, Pubmed Id: 16775218, UMLKSK CUI: C0027746
HumanPANK153354pantothenate kinase 1
img GENERIF, Score=1000, Pubmed Id: 17631502, UMLKSK CUI: C0027746
HumanHTRA227429HtrA serine peptidase 2
img GENERIF, Score=1000, Pubmed Id: 15961413, UMLKSK CUI: C0027746
HumanSLC7A1123657solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
img GENERIF, Score=1000, Pubmed Id: 18469825, UMLKSK CUI: C0027746
HumanBACE123621beta-site APP-cleaving enzyme 1
img GENERIF, Score=1000, Pubmed Id: 16027115, UMLKSK CUI: C0027746
HumanTARDBP23435TAR DNA binding protein
img GENERIF, Score=1000, Pubmed Id: 18288693, UMLKSK CUI: C0027746
HumanPARK711315parkinson protein 7
img GENERIF, Score=694, Pubmed Id: 14712351, UMLKSK CUI: C0027746
HumanSNCAIP9627synuclein, alpha interacting protein
img GENERIF, Score=1000, Pubmed Id: 15322916, UMLKSK CUI: C0027746
img GENERIF, Score=812, Pubmed Id: 12915459, UMLKSK CUI: C0027746
img GENERIF, Score=964, Pubmed Id: 16595633, UMLKSK CUI: C0027746
HumanADAMTS19510ADAM metallopeptidase with thrombospondin type 1 motif, 1
img GENERIF, Score=1000, Pubmed Id: 15661359, UMLKSK CUI: C0027746
HumanCYP7B19420cytochrome P450, family 7, subfamily B, polypeptide 1
img GENERIF, Score=901, Pubmed Id: 18252231, UMLKSK CUI: C0027746
HumanVAPB9217VAMP (vesicle-associated membrane protein)-associated protein B and C
img GENERIF, Score=901, Pubmed Id: 17804640, UMLKSK CUI: C0027746
HumanSLC25A149016solute carrier family 25 (mitochondrial carrier, brain), member 14
img GENERIF, Score=812, Pubmed Id: 16941493, UMLKSK CUI: C0027746
HumanCDK5R18851cyclin-dependent kinase 5, regulatory subunit 1 (p35)
img GENERIF, Score=1000, Pubmed Id: 17121855, UMLKSK CUI: C0027746
HumanBECN18678beclin 1, autophagy related
img GENERIF, Score=1000, Pubmed Id: 18497889, UMLKSK CUI: C0027746
HumanPLA2G68398phospholipase A2, group VI (cytosolic, calcium-independent)
img GENERIF, Score=812, Pubmed Id: 16783378, UMLKSK CUI: C0027746
HumanGAN8139gigaxonin
img GENERIF, Score=1000, Pubmed Id: 17256086, UMLKSK CUI: C0027746
HumanANP32A8125acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
img GENERIF, Score=1000, Pubmed Id: 12807913, UMLKSK CUI: C0027746
HumanPABPN18106poly(A) binding protein, nuclear 1
img GENERIF, Score=1000, Pubmed Id: 15755680, UMLKSK CUI: C0027746
HumanWT17490Wilms tumor 1
img GENERIF, Score=964, Pubmed Id: 12914969, UMLKSK CUI: C0027746
HumanVEGFA7422vascular endothelial growth factor A
img GENERIF, Score=901, Pubmed Id: 16856151, UMLKSK CUI: C0027746
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0027746Nerve Degeneration0self