Genes (114)
Species: human : 111 mouse : 3 | |
Mouse | TFRC | 7037 | transferrin receptor (p90, CD71) | Treatment i.p. with anti-human transferrin receptor immunotoxin or anti-carcinoembryonic antigen immunotoxin and monensin emulsion prolonged the survival of mice with macroscopic i.p. tumor xenografts of H-Meso-1 mesothelioma and LS174T colorectal carcinoma (200-250% increased length of median survival). | Mouse | NF2 | 4771 | neurofibromin 2 (merlin) | Six out of seven mesothelioma cell lines established from neoplastic ascitic fluids of Nf2(KO3/+) mice exhibited loss of the WT Nf2 allele and no neurofibromatosis type 2 protein expression was found in these cells. In order to assess whether NF2 hemizygosity may enhance susceptibility to asbestos fibres, we investigated the Nf2 status in mesothelioma developed in mice presenting a heterozygous mutation of the Nf2 gene (Nf2(KO3/+)), after intraperitoneal inoculation of crocidolite fibres. | Mouse | EPHB4 | 2050 | EPH receptor B4 | In addition, murine tumor xenograft studies using EphB4 oligodeoxynucleotides showed a marked reduction in tumor growth accompanied by a specific decline in EphB4 protein levels, reduced cell division, apoptosis in tumor tissue, and decreased microvascular density.CONCLUSIONS: EphB4 is expressed in mesothelioma, provides a survival advantage to tumor cells, and is therefore a potential novel therapeutic target. | Human | GGT2 | 728441 | gamma-glutamyltransferase 2 | The results of this first quantitative study of a spectrum of biochemical constituents of mesotheliomas identify GGT as an enzyme whose measurement guards against mistaking mesotheliomas and adenocarcinomas for one another and show that the TK concentrations of these mesothelioma samples bear a highly significant, inverse correlation to the postdiagnosis survival time of the individual subjects. | Human | SFTPA1 | 653509 | surfactant protein A1 | SP-A values did not exceed 100 ng.ml-1 in any of 10 mesotheliomas, whilst in 37 of 78 lung adenocarcinomas they did. We studied the value of combined determinations of CEA and SP-A in pleural fluid to distinguish between lung adenocarcinoma and mesothelioma. It is concluded that a combination of CEA and SP-A assays in pleural effusions will be helpful for discriminating lung adenocarcinoma from mesothelioma. SP-A concentrations in pleural effusions due to lung adenocarcinoma and mesothelioma were 516 +/- 140 and 16.9 +/- 3.6 ng.ml-1 (mean +/- SEM), respectively. | Human | CHRFAM7A | 89832 | CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion | Human mesothelioma cells and human biopsies of mesothelioma as well as of normal pleural mesothelial cells functionally express CHRNA7 | Human | ITLN1 | 55600 | intelectin 1 (galactofuranose binding) | Intelectin is consistently and highly overexpressed in a proportion of mesothelioma and gastrointestinal malignancies at the protein level Intelectin mRNA expression was found by RT-PCR in 4 of 5 resected MPM tumors, and Intelectin protein expression was confirmed by immunohistochemistry in 28 of 53 MPM tumors, and in 4 of 4 mesothelioma cell lines studied by Western blot. Intelectin overexpression in mesothelioma could have potential screening, and therapeutic implications. | Human | WIF1 | 11197 | WNT inhibitory factor 1 | Taken together, our studies suggest that WIF-1 silencing due to its promoter hypermethylation is an important mechanism underlying the constitutively activated Wnt signaling in mesothelioma | Human | METAP2 | 10988 | methionyl aminopeptidase 2 | Click here to display 6 evidence detail records. | Human | MSLN | 10232 | mesothelin | Click here to display 46 evidence detail records. | Human | GJC1 | 10052 | gap junction protein, gamma 1, 45kDa | In this study the mRNA expression of Cx43 and three different connexins--Cx37, Cx40 and Cx45, which are highly expressed in lung tissue--was investigated in eight human mesothelioma cell lines, and in human primary mesothelial cells from several donors. No mRNA expression of Cx37, Cx40 or Cx45 in either mesothelioma tumour cells or the primary mesothelial cells was detected. | Human | SEP15 | 9403 | 15 kDa selenoprotein | Growth inhibition and induction of apoptosis in mesothelioma cells by selenium and dependence on selenoprotein SEP15 genotype. | Human | CD163 | 9332 | CD163 molecule | The clone that contained a high sequence homology to the M130 antigen mRNA was expressed in the mesothelioma cell lines M1 and M1A and not in any further investigated cancer cell line. | Human | SOCS3 | 9021 | suppressor of cytokine signaling 3 | Here, we report identification of frequent hypermethylation in CpG islands of the functional SOCS-3 promoter that correlates with its transcription silencing in cell lines (lung cancer, breast cancer, and mesothelioma) and primary lung cancer tissue samples. | Human | CFLAR | 8837 | CASP8 and FADD-like apoptosis regulator | Malignant mesothelioma cells develop an intrinsic resistance to apoptosis induced by death receptors upregulating the expression of the antiapoptotic protein c-FLIP | Human | TNFRSF10A | 8797 | tumor necrosis factor receptor superfamily, member 10a | Malignant mesothelioma cells develop anintrinsic resistance to apoptosis induced by death receptor-4 upregulating the expression of the antiapoptotic protein c-FLIP | Human | TNFRSF10B | 8795 | tumor necrosis factor receptor superfamily, member 10b | We conclude that TRAIL and chemotherapy act cooperatively to kill mesothelioma cell lines, not by increases in DR5 receptor but in association with mitochondrial amplification of apoptotic signals. Mesothelioma cells treated with chemotherapy showed no change in DR5 protein by Western analysis or by immunocytochemistry. | Human | ABCC3 | 8714 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | Canicular multispecific organic anion transporter/MRP genes, primarily 1, 3, 4, 5, and 7, were in fact expressed in these human mesothelioma cell lines as determined by real-time reverse transcription-PCR. | Human | FOSL1 | 8061 | FOS-like antigen 1 | Click here to display 5 evidence detail records. | Human | WNT7A | 7476 | wingless-type MMTV integration site family, member 7A | Furthermore, we identified a homozygous deletion of beta-catenin in the mesothelioma, NCI-H28, associated with reduced WNT7a and the lowest overall cell line expression of HOXA1, HOXA7, HOXA9, and HOXA10, whereas HOXB9 levels were unaffected. | Human | WNT2 | 7472 | wingless-type MMTV integration site family member 2 | Inhibition of Wnt2 by monoclonal antibodies is of therapeutic interest in the development of more effective treatments for malignnt pleueral mesothelioma | Human | WNT1 | 7471 | wingless-type MMTV integration site family, member 1 | Inhibition of Wnt-1 signaling induces apoptosis in beta-catenin-deficient mesothelioma cells. To test whether a Wnt-1 signal is a survival factor in human cancer cells and thus may serve as a potential cancer therapeutic target, we investigated the effect of inhibition of Wnt-1 signaling in a variety of human cancer cell lines, including non small cell lung cancer, breast cancer, mesothelioma, and sarcoma. Here, we show that blocking Wnt-1 signaling in beta-catenin-deficient mesothelioma cell lines H28 and MS-1 induces apoptotic cell death. | Human | VCAM1 | 7412 | vascular cell adhesion molecule 1 | VCAM-1 was detected in 10-50 per cent of the cells in three non-stimulated mesothelioma cell lines (mero-95, mero-96, and mero-134), and was absent or poorly expressed in the remaining 11. The regulation of VCAM-1 expression by neoplastic mesothelial cells was investigated in vitro using 14 mesothelioma cell lines. | Human | TXN | 7295 | thioredoxin | Click here to display 7 evidence detail records. | Human | NKX2-1 | 7080 | | In cytologic preparations, TTF-1 is a highly selective marker for pulmonary adenocarcinoma and also can have a role in the distinction between pulmonary adenocarcinoma and mesothelioma. |
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