Debug Stats | ### Total Build Time: 150 ms 39.213 KB CONCEPT_NAME gt=3 ms Completed: 3 ms rowSize= 320 bytesCONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytesCONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 190 bytes- Skipping details on:
CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes - Skipping details on:
CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 232 bytes- Skipping details on:
CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes CONCEPT_PARENTS gt=2 ms Completed: 2 ms rowSize= 997 bytesCONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytesCONCEPT_ANCESTRAL_ROOTS gt=5 ms Completed: 5 ms rowSize= 4.141 KBCONCEPT_RELATIONSHIPS gt=130 ms Completed: 130 ms rowSize= 14.019 KBCONCEPT_GENES gt=8 ms Completed: 8 ms rowSize= 18.175 KBCONCEPT_XREFS gt=1 ms Completed: 1 ms rowSize= 1.146 KBCONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes- Reload Stats
|
Genes (14)
Species: human : 14 | |
Human | VEGFA | 7422 | vascular endothelial growth factor A | Endometrial blood vessels possess a discrete morphology that is characterized by endothelial gaps, and these gaps are more pronounced in women with menorrhagia and overexpression of VEGFA the concentration of VEGF-A was significantly reduced in the women with menorrhagia, as was the VEGF-A mRNA level Up-regulation of VEGF-A in capillaries in menorrhagia could be involved in abnormal endometrial vascular structure and permeability | Human | MYH9 | 4627 | myosin, heavy chain 9, non-muscle | Mild-significant bleeding episodes (epistaxis, easy bruisability, postoperative hemorrhage, menorrhagia) Mild bleeding episodes (epistaxis, GI bleeding, menorrhagia) Variable bleeding episodes (menorrhagia, easy bruisability, postoperative hemorrhage) | Human | MMP9 | 4318 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | potential role of VEGF-A, MMP-2 and MMP-9, and TNF-alpha in the mechanism of idiopathic excessive uterine bleeding; active form of MMP-9 was reduced in women with menorrhagia | Human | MMP2 | 4313 | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | potential role of VEGF-A, MMP-2 and MMP-9, and TNF-alpha in the mechanism of idiopathic excessive uterine bleeding; active form of MMP-2 was reduced in women with menorrhagia | Human | KDR | 3791 | kinase insert domain receptor (a type III receptor tyrosine kinase) | Endometrial blood vessels possess a discrete morphology that is characterized by endothelial gaps, and these gaps are more pronounced in women with menorrhagia and overexpression of VEGFR2 Up-regulation of VEGF-A receptor VEGFR-2 in capillaries in menorrhagia could be involved in abnormal endometrial vascular structure and permeability | Human | ITGA2B | 3674 | integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) | | Human | GP9 | 2815 | glycoprotein IX (platelet) | | Human | GP1BB | 2812 | glycoprotein Ib (platelet), beta polypeptide | | Human | GP1BA | 2811 | glycoprotein Ib (platelet), alpha polypeptide | | Human | FLT4 | 2324 | fms-related tyrosine kinase 4 | VEGFR-3 may play a role in the abnormal endometrial angiogenesis of idiopathic menorrhagia | Human | FLT1 | 2321 | fms-related tyrosine kinase 1 | Up-regulation of VEGF-A receptor VEGFR-1 in capillaries in menorrhagia could be involved in abnormal endometrial vascular structure and permeability Endometrial blood vessels possess a discrete morphology that is characterized by endothelial gaps, and these gaps are more pronounced in women with menorrhagia and overexpression of VEGFR1 | Human | F5 | 2153 | coagulation factor V (proaccelerin, labile factor) | Bleeding episodes (epistaxis, menorrhagia, ecchymosis) | Human | AQP1 | 358 | aquaporin 1 | The deregulation of aquaporin-1 in menorrhagia may be involved in abnormal endometrial vascular growth and permeability | Human | ANGPT1 | 284 | angiopoietin 1 | loss of normal Ang-1 expression may contribute to the excessive blood loss observed in menorrhagia |
|