Mouse | LAMA1 | 284217 | laminin, alpha 1 | We have screened 208 overlapping synthetic peptides covering the short and long arms of mouse laminin alpha1 chain for their adhesion activity with B16-F10 mouse melanoma cells. |
Mouse | DCD | 117159 | dermcidin | This result suggests that depletion of lean body mass in mice bearing G361 melanoma arises from the production of PIF. |
Mouse | JAM3 | 83700 | junctional adhesion molecule 3 | Especially in murine K-1735 melanoma cell lines, the highly metastatic sublines (M2 and X21) strongly expressed JAM-C when compared with the poorly metastatic ones (C-10 and C23). |
Mouse | AKR1B10 | 57016 | aldo-keto reductase family 1, member B10 (aldose reductase) | Ponalrestat, an aldose reductase inhibitor, inhibits cachexia syndrome in nude mice bearing human melanomas G361 and SEKI. |
Mouse | ENAH | 55740 | enabled homolog (Drosophila) | Profilin II-GFP co-localised with vinculin and Mena to the focal adhesions in REF-52 fibroblasts and was distributed as a thin line at the front of protruding lamellipodia in B16-F1 mouse melanoma cells. |
Mouse | BANP | 54971 | BTG3 associated nuclear protein | Overexpression of SMAR1(S) in mouse melanoma cells (B16F1) and their subsequent injection in C57BL/6 mice delays tumor growth. |
Mouse | CASZ1 | 54897 | castor zinc finger 1 | In addition, mice bearing SRG-transfected melanoma had more tumor formation and larger tumor growth. Melanoma transfected with antisense SRG showed significantly less tumor formation and smaller tumor growth. |
Mouse | EPB41L4B | 54566 | erythrocyte membrane protein band 4.1 like 4B | We have cloned a novel gene, Ehm2, that is expressed in high-metastatic but not in low-metastatic K-1735 murine melanoma cells. Molecular cloning of a novel NF2/ERM/4.1 superfamily gene, ehm2, that is expressed in high-metastatic K1735 murine melanoma cells. |
Mouse | CD244 | 51744 | CD244 molecule, natural killer cell receptor 2B4 | CONCLUSION: Activation of 2B4 and CD48 reduces metastasis of B16F10 melanoma cells and this anti-tumor effect involves both cytolytic function and cytokine production. Wild-type mice rejected CD48(+) melanoma poorly compared with CD48(-) tumor cells, suggesting that ligation of 2B4 by CD48 on melanoma cells is inhibitory. |
Mouse | CCRL1 | 51554 | | We propose that CCR10 engagement by locally produced CCL27 allows melanoma cells to escape host immune antitumor killing mechanisms (possibly through activation of PI3K/Akt), thereby providing a means for tumor progression. Compared with B16 murine melanoma, cells rendered more immunogenic via overexpression of luciferase, B16 cells that overexpressed both luciferase and CCR10 resisted host immune responses and readily formed tumors. |
Mouse | HSPH1 | 10808 | heat shock 105kDa/110kDa protein 1 | DNA vaccination of HSP105 leads to tumor rejection of colorectal cancer and melanoma in mice through activation of both CD4 T cells and CD8 T cells. |
Mouse | POSTN | 10631 | periostin, osteoblast specific factor | Periostin also suppressed in vivo lung metastasis of the mouse melanoma cell line, B16-F10. |
Mouse | TXNIP | 10628 | thioredoxin interacting protein | Click here to display 3 evidence detail records. |
Mouse | HTATIP2 | 10553 | HIV-1 Tat interactive protein 2, 30kDa | Human gene CC3 is a metastasis suppressor for variant small cell lung carcinoma and a mouse melanoma in vivo. |
Mouse | S1PR2 | 9294 | sphingosine-1-phosphate receptor 2 | Overexpression of S1P2 in the melanoma cells resulted in potentiation of S1P inhibition of both Rac and cell migration. In B16F10 mouse melanoma cells, in which S1P2, but not the other S1P receptor subtypes, is endogenously expressed, S1P inhibited cell migration with concomitant inhibition of Rac and stimulation of RhoA in dose-dependent manners. |
Mouse | TMSB10 | 9168 | thymosin beta 10 | We found that expression of thymosin beta-10 mRNA was associated with metastatic behavior of various human melanoma cell lines in nude mice. |
Mouse | HGS | 9146 | hepatocyte growth factor-regulated tyrosine kinase substrate | To clarify the structure and possible function of the 115-kDa protein (designated Hrs for hepatocyte growth factor-regulated tyrosine kinase substrate), we purified this protein from B16-F1 mouse melanoma cells by anti-phosphotyrosine immunoaffinity chromatography and determined its partial amino acid sequences. |
Mouse | WASF1 | 8936 | WAS protein family, member 1 | Malignant B16F10 mouse melanoma cells expressed more WAVE1 and WAVE2 proteins and showed higher Rac activity than B16 parental cells, which are neither invasive nor metastatic. |
Mouse | WISP1 | 8840 | WNT1 inducible signaling pathway protein 1 | Overexpression of a set of genes, including WISP-1, common to pulmonary metastases of both mouse D122 Lewis lung carcinoma and B16-F10.9 melanoma cell lines. |
Mouse | TNFRSF11A | 8792 | tumor necrosis factor receptor superfamily, member 11a, NFKB activator | Jones et al. show that OPG inhibits bone metastasis after intracardiac injection of B16F10 murine melanoma cells, but claim that bone metastases are entirely independent of osteoclast formation and bone resorption: rather, they are caused by an effect on cell migration through RANK. |
Mouse | MAD1L1 | 8379 | MAD1 mitotic arrest deficient-like 1 (yeast) | Our results indicating that Mad1 gene transfer inhibits the proliferation of human melanoma cells suggest that Mad1 could be a potentially useful candidate for the modification of genes against malignancies. |
Mouse | PLA2G7 | 7941 | phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) | RESULTS: When transfected with PAF-AH, KS-Imm human Kaposi;s sarcoma cells implanted in SCID mice and B16F10 mouse melanoma cells implanted in syngenic C57Bl/6J mice showed significantly reduced vascularization and growth allowing longer survival compared with control tumors. |
Mouse | CXCR4 | 7852 | chemokine (C-X-C motif) receptor 4 | Click here to display 5 evidence detail records. |
Mouse | VTNR | 7449 | | Binding of proMMP-2 and proMMP-2/TIMP-2 to melanoma cells was not inhibited by RGDS, and melanoma cell adhesion to vitronectin was unaffected by pro- or active MMP-2, indicating that MMP-2 did not interact with the murine vitronectin receptor. |
Mouse | VCL | 7414 | vinculin | Profilin II-GFP co-localised with vinculin and Mena to the focal adhesions in REF-52 fibroblasts and was distributed as a thin line at the front of protruding lamellipodia in B16-F1 mouse melanoma cells. |