Human | NCF1 | 653361 | neutrophil cytosolic factor 1 | INFERRED, Score=800, UMLKSK CUI: C0024530 |
Human | NCR3 | 259197 | natural cytotoxicity triggering receptor 3 | evidence reported of an association between mild malaria and NCR3 -412G>C polymorphism located within the promoter |
Human | SPPL3 | 121665 | signal peptide peptidase like 3 | SPPL3 cleaves a SPP substrate, but a more distantly related homologue SPPL2b does not, providing strong evidence that the malaria SPP and human SPPL3 have conserved active sites, while the active sites SPPL2b is distinct |
Human | COL18A1 | 80781 | collagen, type XVIII, alpha 1 | INFERRED, Score=800, UMLKSK CUI: C0024530 |
Human | IL21 | 59067 | interleukin 21 | INFERRED, Score=800, UMLKSK CUI: C0024530 |
Human | HAMP | 57817 | hepcidin antimicrobial peptide | Elevated basal hepcidin levels in the liver may inhibit the development of malaria infection |
Human | TLR9 | 54106 | toll-like receptor 9 | Patients with severe and mild malaria showed increased surface expression of TLR2 and TLR4 on CD14(+)monocytes and myeloid dendritic cells and decreased intracellular expression of TLR9 on plasmacytoid dendritic cells compared to healthy controls |
Human | IL23A | 51561 | interleukin 23, alpha subunit p19 | results here show that IL-23 is elevated in children with malarial anemia, and that IL-10 and IL-12 appear to have important regulatory effects on IL-23 production during childhood malaria |
Human | HAVCR1 | 26762 | hepatitis A virus cellular receptor 1 | INFERRED, Score=800, UMLKSK CUI: C0024530 |
Human | VNN1 | 8876 | vanin 1 | Pantetheinase (Vnn1) is critical for the host susceptibility to malaria |
Human | BAT2 | 7916 | | An analysis of 2,162 case-controls demonstrated the first evidence of association between a BAT2 polymorphism (rs1046089) and severe malaria |
Human | VEGFA | 7422 | vascular endothelial growth factor A | INFERRED, Score=800, UMLKSK CUI: C0024530 |
Human | TNFAIP1 | 7126 | tumor necrosis factor, alpha-induced protein 1 (endothelial) | Title:Strong association of a tumor necrosis factor-alpha promoter allele with cerebral malaria in Myanmar.|Association:Y|Conclusion:TNFP-D showed no significant linkage disequilibrium with any alleles of HLA-B or HLA-DRB1, suggesting that TNFP-D was primarily associated with cerebral malaria in Myanmar. |
Human | TNF | 7124 | tumor necrosis factor | Click here to display 10 evidence detail records. |
Human | TLR4 | 7099 | toll-like receptor 4 | TLR4-mediated responses to malaria in vivo and TLR-4 polymorphisms to be associated with disease manifestation Genetic polymorphisms in TLR4, genes are not associated with malaria resistance in patients from Baixo Amazonas region, Brazil Title:|Association:Not Found|Conclusion:Not Found TLR4-mediated responses to malaria in vivo and TLR-4 polymorphisms are associated with disease manifestation |
Human | TLR2 | 7097 | toll-like receptor 2 | Title:|Association:Not Found|Conclusion:Not Found |
Human | TCN2 | 6948 | transcobalamin II | Given the dramatic heterogeneity of the 776G of TCN2 allele frequency worldwide, this polymorphism may be prone to a selective pressure or confers an evolutionary advantage in confronting environmental factors, one of which is malaria |
Human | SPTA1 | 6708 | spectrin, alpha, erythrocytic 1 (elliptocytosis 2) | REVIEW: Culture studies of Plasmodium falciparum in elliptocytes bearing such elliptocytogenic alleles of spectrin showed that these alleles are supplementary genetic factors of malaria resistance |
Human | SLC4A1 | 6521 | solute carrier family 4 (anion exchanger), member 1 | AE1 promoter allele might influence the infection phenotype and the risk of fatal outcome in children with severe malaria conformational change (in a region of the protein involved in the enhanced adhesiveness of Plasmodium falciparum-infected erythrocytes) induced by malaria infection host membrane proteins such as AE1 contribute to the adhesion of malaria-infected erythrocytes to CD36 |
Human | SELE | 6401 | selectin E | Title:|Association:Not Found|Conclusion:Not Found |
Human | CX3CL1 | 6376 | chemokine (C-X3-C motif) ligand 1 | INFERRED, Score=800, UMLKSK CUI: C0024530 |
Human | CCL18 | 6362 | chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) | An in vivo role for DC-CK1 is shown in the establishment of primary T cell responses in mice indicating the potential of DC-CK1 as an adjuvant for vaccines against malaria as well as other diseases in which cellular immune responses are important |
Human | PKLR | 5313 | pyruvate kinase, liver and RBC | Pyruvate kinase deficiency protects against malaria in humans pyruvate kinase deficiency provides protection against infection and replication of P. falciparum in human erythrocytes, raising the possibility that mutant pyruvate kinase alleles may confer a protective advantage against malaria in human populations |
Human | PECAM1 | 5175 | platelet/endothelial cell adhesion molecule 1 | Title:|Association:Not Found|Conclusion:Not Found Title:Association of adhesion molecule PECAM-1/CD31 polymorphism with susceptibility to cerebral malaria in Thais|Association:Y|Conclusion:We found that the frequency of the 125 V/V 563 N/N genotype was significantly high in CM patients as compared with severe cases without CM (P<0.01, OR=2.92), suggesting that this genotype is one of the risk factors for CM. |
Human | NOS2 | 4843 | nitric oxide synthase 2, inducible | Click here to display 9 evidence detail records. |