| Human | NCF1 | 653361 | neutrophil cytosolic factor 1 | INFERRED, Score=800, UMLKSK CUI: C0024530 |
| Human | NCR3 | 259197 | natural cytotoxicity triggering receptor 3 | evidence reported of an association between mild malaria and NCR3 -412G>C polymorphism located within the promoter |
| Human | SPPL3 | 121665 | signal peptide peptidase like 3 | SPPL3 cleaves a SPP substrate, but a more distantly related homologue SPPL2b does not, providing strong evidence that the malaria SPP and human SPPL3 have conserved active sites, while the active sites SPPL2b is distinct |
| Human | COL18A1 | 80781 | collagen, type XVIII, alpha 1 | INFERRED, Score=800, UMLKSK CUI: C0024530 |
| Human | IL21 | 59067 | interleukin 21 | INFERRED, Score=800, UMLKSK CUI: C0024530 |
| Human | HAMP | 57817 | hepcidin antimicrobial peptide | Elevated basal hepcidin levels in the liver may inhibit the development of malaria infection |
| Human | TLR9 | 54106 | toll-like receptor 9 | Patients with severe and mild malaria showed increased surface expression of TLR2 and TLR4 on CD14(+)monocytes and myeloid dendritic cells and decreased intracellular expression of TLR9 on plasmacytoid dendritic cells compared to healthy controls |
| Human | IL23A | 51561 | interleukin 23, alpha subunit p19 | results here show that IL-23 is elevated in children with malarial anemia, and that IL-10 and IL-12 appear to have important regulatory effects on IL-23 production during childhood malaria |
| Human | HAVCR1 | 26762 | hepatitis A virus cellular receptor 1 | INFERRED, Score=800, UMLKSK CUI: C0024530 |
| Human | VNN1 | 8876 | vanin 1 | Pantetheinase (Vnn1) is critical for the host susceptibility to malaria |
| Human | BAT2 | 7916 | | An analysis of 2,162 case-controls demonstrated the first evidence of association between a BAT2 polymorphism (rs1046089) and severe malaria |
| Human | VEGFA | 7422 | vascular endothelial growth factor A | INFERRED, Score=800, UMLKSK CUI: C0024530 |
| Human | TNFAIP1 | 7126 | tumor necrosis factor, alpha-induced protein 1 (endothelial) | Title:Strong association of a tumor necrosis factor-alpha promoter allele with cerebral malaria in Myanmar.|Association:Y|Conclusion:TNFP-D showed no significant linkage disequilibrium with any alleles of HLA-B or HLA-DRB1, suggesting that TNFP-D was primarily associated with cerebral malaria in Myanmar. |
| Human | TNF | 7124 | tumor necrosis factor | Click here to display 10 evidence detail records. |
| Human | TLR4 | 7099 | toll-like receptor 4 | TLR4-mediated responses to malaria in vivo and TLR-4 polymorphisms to be associated with disease manifestation Title:|Association:Not Found|Conclusion:Not Found Genetic polymorphisms in TLR4, genes are not associated with malaria resistance in patients from Baixo Amazonas region, Brazil TLR4-mediated responses to malaria in vivo and TLR-4 polymorphisms are associated with disease manifestation |
| Human | TLR2 | 7097 | toll-like receptor 2 | Title:|Association:Not Found|Conclusion:Not Found |
| Human | TCN2 | 6948 | transcobalamin II | Given the dramatic heterogeneity of the 776G of TCN2 allele frequency worldwide, this polymorphism may be prone to a selective pressure or confers an evolutionary advantage in confronting environmental factors, one of which is malaria |
| Human | SPTA1 | 6708 | spectrin, alpha, erythrocytic 1 (elliptocytosis 2) | REVIEW: Culture studies of Plasmodium falciparum in elliptocytes bearing such elliptocytogenic alleles of spectrin showed that these alleles are supplementary genetic factors of malaria resistance |
| Human | SLC4A1 | 6521 | solute carrier family 4 (anion exchanger), member 1 | conformational change (in a region of the protein involved in the enhanced adhesiveness of Plasmodium falciparum-infected erythrocytes) induced by malaria infection host membrane proteins such as AE1 contribute to the adhesion of malaria-infected erythrocytes to CD36 AE1 promoter allele might influence the infection phenotype and the risk of fatal outcome in children with severe malaria |
| Human | SELE | 6401 | selectin E | Title:|Association:Not Found|Conclusion:Not Found |
| Human | CX3CL1 | 6376 | chemokine (C-X3-C motif) ligand 1 | INFERRED, Score=800, UMLKSK CUI: C0024530 |
| Human | CCL18 | 6362 | chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) | An in vivo role for DC-CK1 is shown in the establishment of primary T cell responses in mice indicating the potential of DC-CK1 as an adjuvant for vaccines against malaria as well as other diseases in which cellular immune responses are important |
| Human | PKLR | 5313 | pyruvate kinase, liver and RBC | pyruvate kinase deficiency provides protection against infection and replication of P. falciparum in human erythrocytes, raising the possibility that mutant pyruvate kinase alleles may confer a protective advantage against malaria in human populations Pyruvate kinase deficiency protects against malaria in humans |
| Human | PECAM1 | 5175 | platelet/endothelial cell adhesion molecule 1 | Title:|Association:Not Found|Conclusion:Not Found Title:Association of adhesion molecule PECAM-1/CD31 polymorphism with susceptibility to cerebral malaria in Thais|Association:Y|Conclusion:We found that the frequency of the 125 V/V 563 N/N genotype was significantly high in CM patients as compared with severe cases without CM (P<0.01, OR=2.92), suggesting that this genotype is one of the risk factors for CM. |
| Human | NOS2 | 4843 | nitric oxide synthase 2, inducible | Click here to display 9 evidence detail records. |