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Details
Link-It Detail - Disease - Lymphoma, Follicular
Debug Stats
  • ### Total Build Time: 105 ms 66.707 KB
  • CONCEPT_NAME gt=14 ms Completed: 14 ms rowSize= 338 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 775 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 187 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=4 ms Completed: 4 ms rowSize= 557 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=9 ms Completed: 9 ms rowSize= 4.072 KB
  • CONCEPT_RELATIONSHIPS gt=51 ms Completed: 51 ms rowSize= 15.914 KB
  • CONCEPT_GENES gt=26 ms Completed: 26 ms rowSize= 43.718 KB
  • CONCEPT_XREFS gt=1 ms Completed: 1 ms rowSize= 1.154 KB
  • CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Lymphoma, Follicular C0024301
Definition (1)
A neoplasm of follicle centre B cells which has at least a partial follicular pattern. Follicular lymphomas comprise about 35% of adult non-Hodgkin lymphomas in the U.S. and 22% worldwide. Most patients have widespread disease at diagnosis. Morphologically, follicular lymphomas are classified as Grade 1, Grade 2, and Grade 3, depending on the percentage of the large lymphocytes present. The vast majority of cases (70-95%) express the BCL-2 rearrangement [t(14;18)]. Histological grade correlates with prognosis. Grades 1 and 2 follicular lymphomas are indolent and grade 3 is more aggressive (adapted from WHO, 2001).
Semantic Types (1)
Neoplastic Process (T191)
Parents (1)
img Lymphoma, Non-Hodgkin C0024305
Ancestral Roots
RootRoot Plus OneDepthParent
img Immune System Diseases C0021053img Immunoproliferative Disorders C00210706img Lymphoma, Non-Hodgkin C0024305
img Hemic and Lymphatic Diseases C0018981img Lymphatic Diseases C00242286img Lymphoma, Non-Hodgkin C0024305
img Neoplasms C0027651img Neoplasms by Histologic Type C00276525img Lymphoma, Non-Hodgkin C0024305
Relationships (135)

Relation Types:
diso_​to_​anat : 31
diso_​to_​chem : 18
diso_​to_​diso : 73
diso_​to_​gene : 9
diso_​to_​phen : 2
diso_​to_​phys : 2


Relationships:
none : 58
associated_​with : 7
gene_​associated_​with_​disease : 6
is_​abnormal_​cell_​of_​disease : 6
is_​associated_​anatomic_​site_​of : 1
is_​normal_​cell_​origin_​of_​disease : 5
is_​normal_​tissue_​origin_​of_​disease : 3
is_​not_​abnormal_​cell_​of_​disease : 2
is_​not_​normal_​cell_​origin_​of_​disease : 3
is_​primary_​anatomic_​site_​of_​disease : 1
isa : 41
may_​treat : 1
permuted_​term_​of : 1
Page Size
Current 25
  Page 1 of 6
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_PHEN272img genetic aspects C0017399
DISO_to_PHEN220img genetic aspects C0017399
DISO_to_CHEM148img Antibodies, Monoclonal C0003250
DISO_to_CHEM119img Antineoplastic Agents C0003392
DISO_to_DISO102img Diffuse Large B-Cell Lymphoma C0079744
DISO_to_CHEM96img Antibodies, Monoclonal C0003250
DISO_to_DISO88img B-Cell Lymphomas C0079731
DISO_to_DISO68img Complication Aspects C1171258
DISO_to_DISO67img B-Cell Lymphomas C0079731
DISO_to_CHEM63img Antineoplastic Agents C0003392
DISO_to_DISO58img Chromosomal translocation C0040715
DISO_to_CHEM51img Antibodies, Monoclonal, Murine-Derived C2916903
DISO_to_DISO51img Chromosomal translocation C0040715
DISO_to_DISO46img Diffuse Large B-Cell Lymphoma C0079744
DISO_to_DISO41img Complication Aspects C1171258
DISO_to_CHEM40img BCL PROTO ONCOGENE PROTEINS 002 C0107696
DISO_to_ANAT39img 14 chromosome C0008656
DISO_to_ANAT38img 18 chromosome C0008660
DISO_to_DISO34img Lymphoma, Non-Hodgkin C0024305
DISO_to_ANAT33img Lymph Nodes C0024204
DISO_to_ANAT32img B-Lymphocytes C0004561
DISO_to_DISO32img Lymphoma, Mantle-Cell C0334634
DISO_to_DISO31img Cutaneous tumor C0037286
DISO_to_DISO29img LOCAL NEOPL RECURRENCE C0027643
DISO_to_DISO28img CELL TRANSFORM NEOPL C0007621
Genes (113)

Species:
human : 113
Page Size
Current 25
  Page 1 of 5
Prior Page
Current 1
SpeciesGeneGeneIdGene NameEvidence
HumanSERPINA9327657serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9
img NCI, Score=801, Pubmed Id: 12819018, UMLKSK CUI: C0024301
img GENERIF, Score=1000, Pubmed Id: 12819018, UMLKSK CUI: C0024301
HumanGCET2257144
img NCI, Score=801, Pubmed Id: 12819018, UMLKSK CUI: C0024301
HumanTNFRSF13C115650tumor necrosis factor receptor superfamily, member 13C
img NCI, Score=801, Pubmed Id: 16025281, UMLKSK CUI: C0024301
HumanIL2159067interleukin 21
img GENERIF, Score=734, Pubmed Id: 17624663, UMLKSK CUI: C0024301
HumanAICDA57379activation-induced cytidine deaminase
img NCI, Score=801, Pubmed Id: 14990977, UMLKSK CUI: C0024301
HumanRHOF54509ras homolog family member F (in filopodia)
img NCI, Score=801, Pubmed Id: 15877735, UMLKSK CUI: C0024301
HumanFOXP350943forkhead box P3
img GENERIF, Score=1000, Pubmed Id: 16825494, UMLKSK CUI: C0024301
HumanMCTS128985malignant T cell amplified sequence 1
img NCI, Score=801, Pubmed Id: 12637315, UMLKSK CUI: C0024301
HumanSWAP7023075SWAP switching B-cell complex 70kDa subunit
img NCI, Score=801, Pubmed Id: 15163014, UMLKSK CUI: C0024301
HumanMALT110892mucosa associated lymphoid tissue lymphoma translocation gene 1
img NCI, Score=801, Pubmed Id: 12393483, UMLKSK CUI: C0024301
img NCI, Score=801, Pubmed Id: 14997743, UMLKSK CUI: C0024301
HumanTNFSF13B10673tumor necrosis factor (ligand) superfamily, member 13b
img NCI, Score=801, Pubmed Id: 11823048, UMLKSK CUI: C0024301
img NCI, Score=801, Pubmed Id: 11823048, UMLKSK CUI: C0024301
img GENERIF, Score=1000, Pubmed Id: 11823048, UMLKSK CUI: C0024301
HumanCXCL1310563chemokine (C-X-C motif) ligand 13
img NCI, Score=801, Pubmed Id: 14595752, UMLKSK CUI: C0024301
img NCI, Score=801, Pubmed Id: 12406091, UMLKSK CUI: C0024301
HumanSEMA4D10507sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
img NCI, Score=801, Pubmed Id: 9665486, UMLKSK CUI: C0024301
img NCI, Score=801, Pubmed Id: 9665486, UMLKSK CUI: C0024301
img NCI, Score=801, Pubmed Id: 9665486, UMLKSK CUI: C0024301
HumanMSC9242musculin
img GENERIF, Score=1000, Pubmed Id: 18368067, UMLKSK CUI: C0024301
HumanSOCS39021suppressor of cytokine signaling 3
img NCI, Score=801, Pubmed Id: 15561778, UMLKSK CUI: C0024301
img NCI, Score=801, Pubmed Id: 15561778, UMLKSK CUI: C0024301
img NCI, Score=801, Pubmed Id: 15561778, UMLKSK CUI: C0024301
HumanBCL108915B-cell CLL/lymphoma 10
img NCI, Score=801, Pubmed Id: 16310461, UMLKSK CUI: C0024301
img NCI, Score=801, Pubmed Id: 10665648, UMLKSK CUI: C0024301
img NCI, Score=801, Pubmed Id: 16310461, UMLKSK CUI: C0024301
HumanTP638626tumor protein p63
img NCI, Score=801, Pubmed Id: 15887287, UMLKSK CUI: C0024301
img NCI, Score=801, Pubmed Id: 15887287, UMLKSK CUI: C0024301
HumanTNFSF118600tumor necrosis factor (ligand) superfamily, member 11
img NCI, Score=801, Pubmed Id: 12756027, UMLKSK CUI: C0024301
img NCI, Score=801, Pubmed Id: 12756027, UMLKSK CUI: C0024301
img GENERIF, Score=1000, Pubmed Id: 12756027, UMLKSK CUI: C0024301
HumanEPR18475
img NCI, Score=801, Pubmed Id: 11086180, UMLKSK CUI: C0024301
HumanNR0B28431nuclear receptor subfamily 0, group B, member 2
img NCI, Score=801, Pubmed Id: 14614518, UMLKSK CUI: C0024301
HumanTCL1A8115T-cell leukemia/lymphoma 1A
img NCI, Score=801, Pubmed Id: 10786666, UMLKSK CUI: C0024301
HumanFOSL18061FOS-like antigen 1
img NCI, Score=801, Pubmed Id: 11590908, UMLKSK CUI: C0024301
HumanCXCR47852chemokine (C-X-C motif) receptor 4
img NCI, Score=801, Pubmed Id: 11368435, UMLKSK CUI: C0024301
img GENERIF, Score=694, Pubmed Id: 17198877, UMLKSK CUI: C0024301
HumanYES17525v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
img NCI, Score=801, Pubmed Id: 3034807, UMLKSK CUI: C0024301
HumanXRCC37517X-ray repair complementing defective repair in Chinese hamster cells 3
img GENERIF, Score=1000, Pubmed Id: 16492913, UMLKSK CUI: C0024301
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0024301Lymphoma, Follicular0self