Debug Stats | ### Total Build Time: 228 ms 70.070 KB CONCEPT_NAME gt=13 ms Completed: 13 ms rowSize= 314 bytesCONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytesCONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 228 bytes- Skipping details on:
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Genes (1107)
Species: human : 1017 mouse : 90 | |
Mouse | JDP2 | 122953 | Jun dimerization protein 2 | Northern blot analysis showed Jdp2 to be alternatively spliced in various normal tissues as well as MLV-induced lymphomas. | Mouse | MUS81 | 80198 | MUS81 structure-specific endonuclease subunit | Remarkably, both homozygous Mus81-/- and heterozygous Mus81+/- mice exhibited a similar susceptibility to spontaneous chromosomal damage and a profound and equivalent predisposition to lymphomas and other cancers. | Mouse | BCL11B | 64919 | B-cell CLL/lymphoma 11B (zinc finger protein) | Bi-allelic changes were found in 17 of the 66 p53-proficient lymphomas with Rit1 LOH but in only 2 of the 54 p53-deficient lymphomas. This suggests an association between the presence of functional p53 and inactivation of the Rit1 gene in the lymphoma development. | Mouse | FBXW7 | 55294 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | Click here to display 3 evidence detail records. | Mouse | AHI1 | 54806 | Abelson helper integration site 1 | Click here to display 5 evidence detail records. | Mouse | UGT1A1 | 54658 | UDP glucuronosyltransferase 1 family, polypeptide A1 | The potentiating effect of vanadium was supported by biochemical analysis of autopsies relating to markers like microsomal cytochrome P-450, UDP glucuronyl transferase (UDPGT) and cytosolic glutathione-S-transferase (GSHT) in the hepatic tissue of the hosts, which showed substantial alterations in the extent of tumor regression as compared to their lymphoma and normal counterparts, prolonging the survival of the hosts. In an attempt to confirm the efficacy of D3 as an antineoplastic agent, the present investigation aims at characterizing the importance of D3 in modulating hepatic drug metabolizing enzymes, namely, cytosolic glutathione S-transferase (GSHT), microsomal UDP glucuronyl transferase (UDPGT), and cytochrome P-450, which have been reported by us in recent literature as significant neoplastic markers in mice bearing Dalton;s lymphoma (DL). | Mouse | DLL4 | 54567 | delta-like 4 (Drosophila) | The Dll4-overexpressing mice eventually developed a lethal phenotype that was characterized by the progression of a T-cell lymphoproliferative disease (restricted to BM and lymphoid tissues) to transplantable monoclonal T-cell leukemia/lymphoma scattered to multiple organs. A novel Notch ligand, Dll4, induces T-cell leukemia/lymphoma when overexpressed in mice by retroviral-mediated gene transfer. | Mouse | BLNK | 29760 | B-cell linker | Our recent findings of defective SLP-65 expression in approximately 50% of childhood pre-B acute lymphoblastic leukemias and spontaneous pre-B cell lymphoma development in SLP-65-/- mice demonstrate that SLP-65 acts as a tumor suppressor. | Mouse | ZNF423 | 23090 | zinc finger protein 423 | Lymphomas with integrations at Ebfaz or Evi3 express the pre-B-cell-specific marker immunoglobulin lambda chain 5, and contain immunoglobulin heavy-chain rearrangements, suggesting that they are blocked at an early B-cell stage. | Mouse | IKZF2 | 22807 | IKAROS family zinc finger 2 (Helios) | Further evidence that ectopic Helios expression contributes to B cell abnormalities was provided by the observation that Helios transgenic mice developed metastatic lymphoma as they aged. | Mouse | PIM2 | 11040 | pim-2 oncogene | Evidence for the involvement of pim-2, a new common proviral insertion site, in progression of lymphomas. The Pim1 gene was targeted by retroviral insertions in 48% of accelerated lymphomas whereas less than 5% contained activated c-Myc and none contained activated Pim2. | Mouse | KLRAP1 | 10748 | killer cell lectin-like receptor subfamily A pseudogene 1 | No Ly-49 antigen was expressed on hybrids when BW5147, a T lymphoma derived from AKR mouse, replaced C58 as parental cell. Induction of Ly-49 on an interspecies hybridoma between differentiation stage specific murine T cells and a rat T lymphoma. | Mouse | DEAF1 | 10522 | DEAF1 transcription factor | In vivo, SPN increases the time of survival of C57BL/6 mice injected with EL-4 lymphoma cells. | Mouse | FRAT1 | 10023 | frequently rearranged in advanced T-cell lymphomas | Click here to display 5 evidence detail records. | Mouse | DMTF1 | 9988 | cyclin D binding myb-like transcription factor 1 | Karyotypic analyses of MEFs and lymphomas from DMP1-null animals revealed pseudodiploid chromosome numbers, consistent with the retention of wild-type p53. Although p53 mutations or Arf deletion normally occur in approximately 50% of E(mu)-Myc-induced lymphomas, Dmp1 loss obviates selection for such mutations, indicating that Dmp1 is a potent genetic modifier of the Arf-p53 pathway in vivo. | Mouse | TP63 | 8626 | tumor protein p63 | p63 and p73 do not contribute to p53-mediated lymphoma suppressor activity in vivo. | Mouse | TCL1A | 8115 | T-cell leukemia/lymphoma 1A | Allele losses at Tcl1, Yy1 genes and D12Mit233 were observed in 94(45%), 143(68%) and 147(70%) of 210 lymphomas, respectively. | Mouse | YWHAB | 7529 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide | Restoration of surface IgM-mediated apoptosis in an anti-IgM-resistant variant of WEHI-231 lymphoma cells by HS1, a protein-tyrosine kinase substrate. Two members of this family (cortactin and HS1) were differentially expressed in murine B lymphoid tumor cell lines; both were detected in plasmacytoma cell lines, however HS1 was additionally detected in pre-B lymphoma and B lymphoma cell lines. | Mouse | YES1 | 7525 | v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 | Thirteen other proto-oncogenes (c-mos, c-sis, c-rel, c-yes, c-fes3, c-fes4, c-fos, c-fms, c-src, c-erbA, c-erbB, int-1, Pim-1) were not expressed in any of the T lymphoma cells tested. | Mouse | XRCC5 | 7520 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | Loss of p53 synergizes with Ku80 to promote tumorigenesis such that all Ku80-/- p53-/- mice succumb to disseminated pro-B-cell lymphoma before three months of age. Loss of p53 synergizes with Ku80 to promote tumorigenesis such that all Ku80-/- p53-/- mice succumb to disseminated pro-B-cell lymphoma before three months of age. | Mouse | XRCC4 | 7518 | X-ray repair complementing defective repair in Chinese hamster cells 4 | Although p53-deficiency allowed postnatal survival of XRCC4-deficient mice, they routinely succumbed to pro-B-cell lymphomas which had chromosomal translocations linking amplified c-myc oncogene and IgH locus sequences. Mice doubly deficient for either XRCC4 or DNA ligase IV and p53 invariably develop lymphomas bearing characteristic chromosome translocations with gene amplification. | Mouse | VCAM1 | 7412 | vascular cell adhesion molecule 1 | VCAM-1 is not involved in LPAM-1 (alpha 4 beta p/alpha 4 beta 7) mediated binding of lymphoma cells to high endothelial venules of mucosa-associated lymph nodes. In vitro adhesion of the lymphoma tumor cells to a mouse endothelioma cell line was strongly inhibited by monoclonal antibodies interfering with the interaction of VCAM-1 with VLA-4. | Mouse | TYK2 | 7297 | tyrosine kinase 2 | RAG2/TYK2 double-knockout mice succumbed to A-MuLV-induced leukemia/lymphoma faster than RAG2(-/-)TYK2(+/-) mice. Mice deficient in TYK2 developed Abelson-induced B lymphoid leukemia/lymphoma as well as TEL-JAK2-induced T lymphoid leukemia with a higher incidence and shortened latency compared with WT controls. | Mouse | TNFSF4 | 7292 | tumor necrosis factor (ligand) superfamily, member 4 | Introduction of OX40 ligand into lymphoma cells elicits anti-lymphoma immunity in vivo. Introduction of OX40 ligand into lymphoma cells elicits anti-lymphoma immunity in vivo. | Mouse | TRB@ | 6957 | | The absolute number of trans-rearrangements between the TCRG and TCRB loci is predictive of lymphoma risk: a severe combined immune deficiency (SCID) murine model. The first constant region of the Tcrb gene was completely deleted from the DNA of 8/10 mouse cell lines established from 3-methylcholanthrene-induced RF/J thymic lymphomas, but 6/7 primary lymphomas contained the first constant region sequences. |
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