Human | NEWENTRY | 192343 | Record to support submission of GeneRIFs for a gene not in Gene (human; man). | Immunodetection of glomerular C4d deposition in renal biopsy samples could be a convenient method of identifying patients at risk of thrombotic microangiopathy in lupus nephritis [complement C4d] electron dense C4d (complement 4d) deposition in peritubular capillaries was observed in most Lupus Nephritis patients [complement 4d] |
Human | TLR9 | 54106 | toll-like receptor 9 | These findings suggest that tubular TLR-9 activation has a pathogenetic role in tubulointerstitial inflammation and damage in experimental and human lupus nephritis |
Human | IL20 | 50604 | interleukin 20 | novel effects of IL-20 on mesangial cells and its association with lupus nephritis |
Human | ANKRD1 | 27063 | ankyrin repeat domain 1 (cardiac muscle) | CARP was expressed in renal podocytes at a high level in 10 of 13 cases of crescentic glomerulonephritis, 7 of 19 cases of diabetic nephropathy, and 12 of 20 cases of lupus nephritis |
Human | ICOSLG | 23308 | inducible T-cell co-stimulator ligand | A critical role of the B7-like protein-ICOS costimulatory pathway is demonstrated in the pathogenesis of lupus nephritis |
Human | SELE | 6401 | selectin E | The severity and diversity of the histopathology of lupus nephritis are partially associated with the expression of E-selectin, P-selectin, and VCAM-1 in glomeruli |
Human | CCL5 | 6352 | chemokine (C-C motif) ligand 5 | in lupus nephritis RANTES may participate in interstitial lesions via CCR5+ cells |
Human | CCL2 | 6347 | chemokine (C-C motif) ligand 2 | an A/G or G/G genotype may predispose to the development of systemic lupus erythematosus and further indicate that the patients with these genotypes may be at higher risk of developing lupus nephritis |
Human | RARRES3 | 5920 | retinoic acid receptor responder (tazarotene induced) 3 | retinoic acid-inducible gene-I is expressed in lupus nephritis [letter] |
Human | PTGS2 | 5743 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | in lupus nephritis COX-2 and monocytes/ macrophages but not COX-1 isoform are involved in the inflammatory process |
Human | PDCD1 | 5133 | programmed cell death 1 | regulatory single nucleotide polymorphism PD1.3G/A was shown to be involved in susceptibility to childhood-onset systemic lupus erythematosus but not lupus nephritis the association between lupus nephritis and PDCD1 was weaker in European American than in Swedish families |
Human | SERPINE1 | 5054 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | Title:Plasminogen activator inhibitor-1 gene polymorphism 4G/4G genotype and lupus nephritis in Chinese patients|Association:Y|Conclusion:These findings suggest that the 4G/5G polymorphism of the PAI-1 gene is associated with the activity but not the chronicity of lupus nephritis. The presence of the 4G4G genotype does not increase the risk of developing SLE or lupus nephritis, but predicts the development of higher nephritis activity and more extensive necrotizing lesions. Our findings suggest that risk of glomerular microthrombosis in lupus nephritis is attributable, at least in part, to an epistatic effect of PAI-1 and FGB genes |
Human | NOS3 | 4846 | nitric oxide synthase 3 (endothelial cell) | no significant increased risk of systemic lupus erythematosis and/or lupus nephritis associated with eNOS or ACE polymorphisms in either the African American or Caucasian groups |
Human | NOS1 | 4842 | nitric oxide synthase 1 (neuronal) | Intron4 polymorphism of the nitric oxide synthase gene is associated with the development of lupus nephritis |
Human | MPO | 4353 | myeloperoxidase | the low expressing A allele is a significant risk factor for developing lupus nephritis that is gene dosage-dependent in African Americans |
Human | IL18 | 3606 | interleukin 18 (interferon-gamma-inducing factor) | Patients with severe lupus nephritis showed a high accumulation of IL-18 within glomeruli in association with the presence of plasmacytoid dendritic cells interleukin-18 production is increased in patients with lupus nephritis |
Human | IL10 | 3586 | interleukin 10 | Patients carrying the -592 C allele had a higher risk of diffuse proliferative glomerulonephritis, indicating the genetic influence of the IL-10 gene polymorphism in the renal lesions of lupus nephritis |
Human | ICAM1 | 3383 | intercellular adhesion molecule 1 | ICAM-1 may have a role in inflammation in systemic lupus erythematosus patients with lupus nephritis |
Human | FCGR3A | 2214 | Fc fragment of IgG, low affinity IIIa, receptor (CD16a) | Title:The Fcgamma receptor IIIA-158F allele is a major risk factor for the development of lupus nephritis among Caucasians but not non-Caucasians|Association:Not Found|Conclusion:The FcgammaRIIIA-158F allele is a major risk factor for the development of lupus nephritis among Caucasians, but not among non-Caucasians. These results suggest that ethnic variation is critical in defining the specific genetic factors underlying the pathogenesis of SLE, and they have important prognostic and therapeutic implications as well. |
Human | FCGR2A | 2212 | Fc fragment of IgG, low affinity IIa, receptor (CD32) | Role of the Fcgamma receptor IIa polymorphism in susceptibility to systemic lupus erythematosus and lupus nephritis Title:The Fcgamma receptor IIIA-158F allele is a major risk factor for the development of lupus nephritis among Caucasians but not non-Caucasians|Association:Not Found|Conclusion:The FcgammaRIIIA-158F allele is a major risk factor for the development of lupus nephritis among Caucasians, but not among non-Caucasians. These results suggest that ethnic variation is critical in defining the specific genetic factors underlying the pathogenesis of SLE, and they have important prognostic and therapeutic implications as well. |
Human | DUSP1 | 1843 | dual specificity phosphatase 1 | our data suggest that deletion of the hv3005 and the 3-30.3 genes may predispose individual SLE patients to the development of lupus nephritis |
Human | ACE | 1636 | angiotensin I converting enzyme | insertion/deletion polymorphisms of ACE gene did not affect susceptibility to systemic lupus erythematosus, lupus nephritis and the vascular manifestations, including Raynaud's phenomenon, in Korean SLE patients no significant increased risk of systemic lupus erythematosis and/or lupus nephritis associated with eNOS or ACE polymorphisms in either the African American or Caucasian groups |
Human | CCR5 | 1234 | chemokine (C-C motif) receptor 5 (gene/pseudogene) | Polymorphisms of CCR2 and CCR5 do not seem to be involved in susceptibility to systemic lupus erythematosis, although a slight contribution of the CCR5 polymorphism in the production of anti-dsDNA autoantibodies, in the development of lupus nephritis in lupus nephritis RANTES may participate in interstitial lesions via CCR5+ cells |
Human | CD40LG | 959 | CD40 ligand | Results indicate that patients with active lupus nephritis exhibit B cell abnormalities that are consistent with intensive germinal center activity, are driven via CD154-CD40 interactions, and may be involved in the production of autoantibodies |
Human | CASP3 | 836 | caspase 3, apoptosis-related cysteine peptidase | Activated caspase-3-positive cells were present in glomeruli of 88.2% of lupus nephritis cases, observed in the glomerular tuft and cellular and fibrocellular crescents |