| Mouse | CASC1 | 55259 | cancer susceptibility candidate 1 | Click here to display 3 evidence detail records. |
| Mouse | SH3GLB1 | 51100 | SH3-domain GRB2-like endophilin B1 | Nevertheless, when compared with the combined human ACs, 39 genes with similar expression changes in murine lung tumors and human ACs/LCCs were identified, such as the oncogene-related BCL7B, the cell cycle regulator CDK4, and the proapoptotic Endophilin B1. |
| Mouse | POLM | 27434 | polymerase (DNA directed), mu | Primer extension assays with purified BALB/cJ and A/J proteins in vitro demonstrate that both forms of Pol iota are active but that they may differ in substrate discrimination, which may affect the formation of Kras2 mutations in mouse lung tumors. |
| Mouse | RCHY1 | 25898 | ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase | Pirh2 protein expression was higher in 27 (84%) of 32 human lung neoplasms than in matched normal lung tissue and in 14 of 15 mouse lung tumors evaluated. |
| Mouse | CADM1 | 23705 | cell adhesion molecule 1 | These findings, together with frequent loss of their expression in lung cancers, suggest that TSLC1 and DAL-1 play a critical role in the same pathway involved in the suppression of lung tumor formation and metastasis. |
| Mouse | BCL7B | 9275 | B-cell CLL/lymphoma 7B | Nevertheless, when compared with the combined human ACs, 39 genes with similar expression changes in murine lung tumors and human ACs/LCCs were identified, such as the oncogene-related BCL7B, the cell cycle regulator CDK4, and the proapoptotic Endophilin B1. |
| Mouse | CCNB2 | 9133 | cyclin B2 | Two suggested biomarkers found in mouse lung tumors are DNA hypomethylation and alterations in mRNA expression of genes, such as 18S RNA, caspase 3, cyclin B2, cyclin E1, iNOS and survivin. |
| Mouse | XPC | 7508 | xeroderma pigmentosum, complementation group C | Deletion of Gadd45a alone does not lead to increased lung tumors in mice, but coupled with an XPC deletion, it results in lung tumor progression. Deletion of XPC leads to lung tumors in mice and is associated with early events in human lung carcinogenesis. |
| Mouse | SDC1 | 6382 | syndecan 1 | Western blot analyses confirmed that several of these proteins were elevated in the lung tumors and immunohistochemical analyses identified 3 proteins, microsomal glutathione-S-transferase 1 (Mgst1), cathepsin H and syndecan 1 as being consistently elevated in the murine lung tumors compared to non-tumor bearing transgenic lung tissue and normal lung tissue surrounding the tumor. |
| Mouse | S100A9 | 6280 | S100 calcium binding protein A9 | Several lines of evidence indicate that in situ activation of macrophages was responsible for the therapeutic effects of MLV-CGP 31362: (a) macrophages harvested from the lungs of treated mice had significant tumoricidal activity against cultured renal carcinoma cells, (b) activated macrophages, as defined by the MRP-14 marker, were present in lung tumor nodules of treated mice but not untreated mice, and (c) the in situ activation of alveolar macrophages was consistent with the in vivo deposition of 60% of radiolabeled MLV-CGP 31362 liposomes in the lungs following i.v. injection. |
| Mouse | RRM1 | 6240 | ribonucleotide reductase M1 | We generated strains of RRM1 transgenic mice and found that carcinogen-induced lung tumor formation was significantly suppressed. |
| Mouse | PMP22 | 5376 | peripheral myelin protein 22 | Our data suggest that the pathogenesis of urethan-induced lung tumors in mice involves specific and recurrent molecular alterations (Ki-ras mutations, decrease of Rb and gas-3 expression, and increase of c-myc expression) that could represent different steps in lung carcinogenesis. |
| Mouse | NUDT1 | 4521 | nudix (nucleoside diphosphate linked moiety X)-type motif 1 | The increased occurrence of lung tumor in OGG1-deficient mice was completely abolished by the concomitant disruption of the Mth1 gene. The increased occurrence of lung tumors in OGG1-null mice was abolished by the concomitant disruption of the Mth1 gene, indicating that an increased accumulation of 8-oxoG and/or 2-OH-A might cause cell death. |
| Mouse | MST1R | 4486 | macrophage stimulating 1 receptor (c-met-related tyrosine kinase) | This model provides opportunities to study the role of RON in the pathogenesis of lung tumors and to elucidate the mechanisms underlying this distinct lung tumor. These results indicate that overexpression of human wild-type RON causes the formation of lung tumors with unique biological characteristics in vivo. |
| Mouse | MMP12 | 4321 | matrix metallopeptidase 12 (macrophage elastase) | Click here to display 4 evidence detail records. |
| Mouse | MGST1 | 4257 | microsomal glutathione S-transferase 1 | Western blot analyses confirmed that several of these proteins were elevated in the lung tumors and immunohistochemical analyses identified 3 proteins, microsomal glutathione-S-transferase 1 (Mgst1), cathepsin H and syndecan 1 as being consistently elevated in the murine lung tumors compared to non-tumor bearing transgenic lung tissue and normal lung tissue surrounding the tumor. Therefore, our findings indicate that Mgst1, cathepsin H and syndecan 1 should be further evaluated as markers capable of identifying patients with early stage lung tumors. |
| Mouse | IL15 | 3600 | interleukin 15 | Combination chemotherapy and IL-15 administration induce permanent tumor regression in a mouse lung tumor model: NK and T cell-mediated effects antagonized by B cells. |
| Mouse | ERAS | 3266 | ES cell expressed Ras | Click here to display 4 evidence detail records. |
| Mouse | GJA4 | 2701 | gap junction protein, alpha 4, 37kDa | Whilst mutations of the cx 32 gene appear to be rare in tumors, cx 37 gene mutations have been reported in a mouse lung tumor cell line. |
| Mouse | GADD45A | 1647 | growth arrest and DNA-damage-inducible, alpha | Deletion of Gadd45a alone does not lead to increased lung tumors in mice, but coupled with an XPC deletion, it results in lung tumor progression. |
| Mouse | CTSH | 1512 | cathepsin H | Western blot analyses confirmed that several of these proteins were elevated in the lung tumors and immunohistochemical analyses identified 3 proteins, microsomal glutathione-S-transferase 1 (Mgst1), cathepsin H and syndecan 1 as being consistently elevated in the murine lung tumors compared to non-tumor bearing transgenic lung tissue and normal lung tissue surrounding the tumor. |
| Mouse | CDK6 | 1021 | cyclin-dependent kinase 6 | Cdkn2a became a primary candidate for Papg-1 for two reasons: (1) two haplotypes of mouse Cdkn2a were found to segregate with differential genetic susceptibility to lung tumor progression in mice; and (2) in vitro studies showed that the p16(INK4a) allele from the BALB/cJ mouse had a significantly decreased ability to bind and inhibit CDK6 and to suppress cell growth when compared with the p16(INK4a) allele from the A/J mouse. |
| Mouse | BNIP2 | 663 | BCL2/adenovirus E1B 19kDa interacting protein 2 | When we compared lung adenomas, lung ACs, and normal lung parenchyma, 24 developmentally regulated genes were found aberrantly expressed in lung tumors; these included the cell cycle control factor CDC5, the cellular differentiation factor TEA domain 4, and the proapoptotic factor BNIP 2. |
| Mouse | BCAT1 | 586 | branched chain amino-acid transaminase 1, cytosolic | Of the other four genes (Eca39, RIKEN Ak015530, mHoj-1, and Krag), no functional polymorphisms or differential gene expression were found in Eca39, mHoj-1, and Krag between lung tumor-susceptible and -resistant strains. |
| Mouse | ASCL1 | 429 | achaete-scute complex homolog 1 (Drosophila) | Mice carrying conditional alleles for both Rb-1 and p53 in lung epithelial cells develop aggressive lung tumors with similarities to human small cell lung cancers, including high level expression of ASH-1, NE markers, and extra-pulmonary metastases. |
