Mouse | TXNIP | 10628 | thioredoxin interacting protein | Approximately 40% of the Txnip-deficient mice developed hepatic tumors with an increased prevalence in male mice. |
Mouse | TIMP1 | 7076 | TIMP metallopeptidase inhibitor 1 | Using a double transgenic murine hepatic tumor model, we demonstrate that tissue inhibitor of metalloproteinase 1 (TIMP-1) blocks liver hyperplasia during tumor development, despite TAg-mediated reactivation of IGF-II. |
Mouse | TNFRSF9 | 3604 | tumor necrosis factor receptor superfamily, member 9 | More importantly, intratumoral delivery of GM-CSF and IL-12 genes in combination with 4-1BB costimulation greatly improved the long-term survival rate of mice bearing large tumors and eradicated the untreated existing hepatic tumor. |
Mouse | IL1RN | 3557 | interleukin 1 receptor antagonist | The observed altered gene expression may be related to biological phenotypes of hepatic tumors, and IL-1ra in particular may positively influence tumor cell growth through its antagonism of IL-1. RT-PCR analysis demonstrated that mouse hepatic tumors contain both secreted and intracellular forms of IL-1ra. |
Mouse | HDGF | 3068 | hepatoma-derived growth factor | It is suggested that HDGF was secreted or released from these foci and stimulated hepatocyte proliferation in a paracrine manner in FLS mice, and stimulated the proliferation of hepatic tumor cells in an autocrine manner. |
Human | LOC100507436 | 100507436 | | INFERRED, Score=800, UMLKSK CUI: C0023895 |
Human | ZGLP1 | 100125288 | zinc finger, GATA-like protein 1 | INFERRED, Score=800, UMLKSK CUI: C0023895 |
Human | OCTN3 | 100049579 | organic cation transporter 3 | INFERRED, Score=800, UMLKSK CUI: C0023895 |
Human | CCR2 | 729230 | chemokine (C-C motif) receptor 2 | INFERRED, Score=800, UMLKSK CUI: C0023895 |
Human | HULC | 728655 | hepatocellular carcinoma up-regulated long non-coding RNA | INFERRED, Score=800, UMLKSK CUI: C0023895 |
Human | GGT2 | 728441 | gamma-glutamyltransferase 2 | Sera from 95 hepatobiliary patients showed typical isoenzyme features: (a) a beta-migrating GGT form that was less than 10% of the total GGT in chronic hepatitis and cirrhosis, and less than or equal to 30% of the total GGT in cirrhosis with intrahepatic cholestasis and in cases of extra- and intrahepatic obstructive jaundice, including liver neoplasias; (b) a gamma-migrating GGT band and (or) a ;dep-GGT; (nonmigrating) band in cases of extrahepatic jaundice; and (c) an albumin-migrating GGT band that had a diagnostic sensitivity of 75% for hepatic tumors. We have found significantly elevated values of salivary GGT in cirrhosis of the liver (8.3 +/- 0.9 [mean +/- SEM] units/L), hepatic tumors (10.4 +/- 1.3 units/L), acute cholecystitis (18.3 +/- 2 units/L), acute pancreatitis (15.1 +/- 2.4 units/L), diabetic ketoacidosis (11.6 +/- 1 units/L), and Sjogrens syndrome (19.6 +/- 4.8 units/L). |
Human | ZG16 | 653808 | zymogen granule protein 16 | INFERRED, Score=800, UMLKSK CUI: C0023895 |
Human | NCF1 | 653361 | neutrophil cytosolic factor 1 | INFERRED, Score=800, UMLKSK CUI: C0023895 |
Human | LOC652799 | 652799 | | INFERRED, Score=800, UMLKSK CUI: C0023895 |
Human | HEPN1 | 641654 | hepatocellular carcinoma, down-regulated 1 | INFERRED, Score=800, UMLKSK CUI: C0023895 |
Human | PIM3 | 415116 | pim-3 oncogene | INFERRED, Score=800, UMLKSK CUI: C0023895 |
Human | MIR223 | 407008 | microRNA 223 | INFERRED, Score=800, UMLKSK CUI: C0023895 |
Human | MIR21 | 406991 | microRNA 21 | INFERRED, Score=800, UMLKSK CUI: C0023895 |
Human | MIR146A | 406938 | microRNA 146a | INFERRED, Score=800, UMLKSK CUI: C0023895 |
Human | MIR122 | 406906 | microRNA 122 | INFERRED, Score=800, UMLKSK CUI: C0023895 |
Human | NHLRC1 | 378884 | NHL repeat containing 1 | INFERRED, Score=800, UMLKSK CUI: C0023895 |
Human | MIA3 | 375056 | melanoma inhibitory activity family, member 3 | INFERRED, Score=800, UMLKSK CUI: C0023895 |
Human | GLDN | 342035 | gliomedin | INFERRED, Score=800, UMLKSK CUI: C0023895 |
Human | HIST2H3A | 333932 | histone cluster 2, H3a | INFERRED, Score=800, UMLKSK CUI: C0023895 |
Human | SNAI3 | 333929 | snail family zinc finger 3 | INFERRED, Score=800, UMLKSK CUI: C0023895 |