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Details
Link-It Detail - Disease - Lichen Planus
Debug Stats
  • ### Total Build Time: 186 ms 35.591 KB
  • CONCEPT_NAME gt=10 ms Completed: 10 ms rowSize= 324 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 693 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 188 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=10 ms Completed: 10 ms rowSize= 555 bytes
  • CONCEPT_CHILDREN gt=5 ms Completed: 5 ms rowSize= 557 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=7 ms Completed: 7 ms rowSize= 1.515 KB
  • CONCEPT_RELATIONSHIPS gt=107 ms Completed: 107 ms rowSize= 13.467 KB
  • CONCEPT_GENES gt=42 ms Completed: 42 ms rowSize= 17.172 KB
  • CONCEPT_XREFS gt=3 ms Completed: 3 ms rowSize= 1.147 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Lichen Planus C0023646
Definition (1)
An inflammatory, pruritic disease of the skin and mucous membranes, which can be either generalized or localized. It is characterized by distinctive purplish, flat-topped papules having a predilection for the trunk and flexor surfaces. The lesions may be discrete or coalesce to form plaques. Histologically, there is a "saw-tooth" pattern of epidermal hyperplasia and vacuolar alteration of the basal layer of the epidermis along with an intense upper dermal inflammatory infiltrate composed predominantly of T-cells. Etiology is unknown.
Semantic Types (1)
Disease or Syndrome (T047)
Parents (1)
img Lichenoid Eruptions C0162848
Children (1)
img Lichen Planus, Oral C0206139
Ancestral Roots
RootRoot Plus OneDepthParent
img Skin and Connective Tissue Diseases C0175166img Skin Diseases C00372745img Lichenoid Eruptions C0162848
Relationships (74)

Relation Types:
diso_​to_​anat : 5
diso_​to_​chem : 6
diso_​to_​diso : 62
diso_​to_​phen : 1


Relationships:
none : 38
classifies : 1
is_​associated_​anatomic_​site_​of : 1
is_​finding_​of_​disease : 1
is_​primary_​anatomic_​site_​of_​disease : 1
isa : 10
mapped_​to : 21
used_​for : 1
Page Size
Current 25
  Page 1 of 3
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_DISO80img Complication Aspects C1171258
DISO_to_DISO72img Complication Aspects C1171258
DISO_to_ANAT28img Skin C1123023
DISO_to_DISO24img Alopecia C0002170
DISO_to_DISO24img DISORDER VULVA C0042994
DISO_to_DISO22img chemically induced C0007994
DISO_to_DISO21img chemically induced C0007994
DISO_to_CHEM18img Immunosuppressive Agents C0021081
DISO_to_DISO17img Cutaneous tumor C0037286
DISO_to_DISO16img Hepatitis C C0019196
DISO_to_CHEM15img Tacrolimus C0085149
DISO_to_DISO15img DISORDER VULVA C0042994
DISO_to_CHEM14img Tacrolimus C0085149
DISO_to_DISO14img Carcinoma, Squamous Cell C0007137
DISO_to_DISO13img Carcinoma, Squamous Cell C0007137
DISO_to_DISO13img Cutaneous tumor C0037286
DISO_to_DISO13img Dermatoses, Hand C0018567
DISO_to_DISO13img Esophageal Diseases C0014852
DISO_to_CHEM12img Immunosuppressive Agents C0021081
DISO_to_DISO12img Alopecia C0002170
DISO_to_DISO12img Nail Diseases C0027339
DISO_to_DISO11img Dermatoses, Scalp C0036271
DISO_to_PHEN11img genetic aspects C0017399
DISO_to_DISO10img Dermatoses, Foot C0016509
DISO_to_DISO10img PSORIASIS C0033860
Genes (23)

Species:
human : 23
SpeciesGeneGeneIdGene NameEvidence
HumanDEFB103B55894defensin, beta 103B
img GENERIF, Score=1000, Pubmed Id: 12825122, UMLKSK CUI: C0023646
HumanTOP2A7153topoisomerase (DNA) II alpha 170kDa
INFERRED, Score=800, UMLKSK CUI: C0023646
HumanTNF7124tumor necrosis factor
img GENERIF, Score=1000, Pubmed Id: 14962095, UMLKSK CUI: C0023646
HumanSPP16696secreted phosphoprotein 1
INFERRED, Score=800, UMLKSK CUI: C0023646
HumanCCL56352chemokine (C-C motif) ligand 5
INFERRED, Score=800, UMLKSK CUI: C0023646
HumanNTRK14914neurotrophic tyrosine kinase, receptor, type 1
INFERRED, Score=800, UMLKSK CUI: C0023646
HumanNGFR4804nerve growth factor receptor
INFERRED, Score=800, UMLKSK CUI: C0023646
HumanNGF4803nerve growth factor (beta polypeptide)
INFERRED, Score=800, UMLKSK CUI: C0023646
HumanMMP94318matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
img GENERIF, Score=1000, Pubmed Id: 16919028, UMLKSK CUI: C0023646
HumanCXCL103627chemokine (C-X-C motif) ligand 10
INFERRED, Score=800, UMLKSK CUI: C0023646
HumanIDO13620indoleamine 2,3-dioxygenase 1
img GENERIF, Score=1000, Pubmed Id: 18055547, UMLKSK CUI: C0023646
HumanIL183606interleukin 18 (interferon-gamma-inducing factor)
INFERRED, Score=800, UMLKSK CUI: C0023646
HumanIL103586interleukin 10
INFERRED, Score=800, UMLKSK CUI: C0023646
HumanIL63569interleukin 6 (interferon, beta 2)
INFERRED, Score=800, UMLKSK CUI: C0023646
HumanIL1B3553interleukin 1, beta
INFERRED, Score=800, UMLKSK CUI: C0023646
HumanIFNG3458interferon, gamma
img GENERIF, Score=1000, Pubmed Id: 14962095, UMLKSK CUI: C0023646
HumanHLA-DRB13123
img GENERIF, Score=1000, Pubmed Id: 17665209, UMLKSK CUI: C0023646
HumanHLA-DRA3122
INFERRED, Score=800, UMLKSK CUI: C0023646
HumanCXCR32833chemokine (C-X-C motif) receptor 3
INFERRED, Score=800, UMLKSK CUI: C0023646
HumanCCR51234chemokine (C-C motif) receptor 5 (gene/pseudogene)
INFERRED, Score=800, UMLKSK CUI: C0023646
HumanCD44960CD44 molecule (Indian blood group)
INFERRED, Score=800, UMLKSK CUI: C0023646
HumanCASP3836caspase 3, apoptosis-related cysteine peptidase
INFERRED, Score=800, UMLKSK CUI: C0023646
HumanBCL2596B-cell CLL/lymphoma 2
img GENERIF, Score=1000, Pubmed Id: 18410632, UMLKSK CUI: C0023646
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0023646Lichen Planus0self