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Details
Link-It Detail - Disease - Leukoencephalopathy, Progressive Multifocal
Debug Stats
  • ### Total Build Time: 103 ms 35.014 KB
  • CONCEPT_NAME gt=5 ms Completed: 5 ms rowSize= 384 bytes
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  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Leukoencephalopathy, Progressive Multifocal C0023524
Definition (1)
An opportunistic viral infection of the central nervous system associated with conditions that impair cell-mediated immunity (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME and other IMMUNOLOGIC DEFICIENCY SYNDROMES; HEMATOLOGIC NEOPLASMS; IMMUNOSUPPRESSION; and COLLAGEN DISEASES). The causative organism is JC Polyomavirus (JC VIRUS) which primarily affects oligodendrocytes, resulting in multiple areas of demyelination. Clinical manifestations include DEMENTIA; ATAXIA; visual disturbances; and other focal neurologic deficits, generally progressing to a vegetative state within 6 months. (From Joynt, Clinical Neurology, 1996, Ch26, pp36-7)
Semantic Types (1)
Disease or Syndrome (T047)
Parents (5)
img Leukoencephalopathies C0270612
img Polyomavirus Infections C0949804
img Demyelinating Diseases C0011303
img Slow Virus Diseases C0037341
img Encephalitis, Viral C0243010
Ancestral Roots
RootRoot Plus OneDepthParent
img Nervous System Diseases C0027765img Central Nervous System Diseases C00076824img Leukoencephalopathies C0270612
img Nervous System Diseases C0027765img Central Nervous System Diseases C00076825img Leukoencephalopathies C0270612
img Virus Diseases C0042769img DNA Virus Infections C00129224img Polyomavirus Infections C0949804
img Nervous System Diseases C0027765img Demyelinating Diseases C00113033img Demyelinating Diseases C0011303
img Virus Diseases C0042769img Slow Virus Diseases C00373413img Slow Virus Diseases C0037341
img Virus Diseases C0042769img Encephalitis, Viral C02430103img Encephalitis, Viral C0243010
img Nervous System Diseases C0027765img Central Nervous System Diseases C00076826img Encephalitis, Viral C0243010
img Virus Diseases C0042769img Central Nervous System Viral Diseases C03481655img Encephalitis, Viral C0243010
img Nervous System Diseases C0027765img Central Nervous System Diseases C00076827img Encephalitis, Viral C0243010
img Bacterial Infections and Mycoses C0004615img Central Nervous System Infections C00076846img Encephalitis, Viral C0243010
img Bacterial Infections and Mycoses C0004615img Central Nervous System Infections C00076845img Encephalitis, Viral C0243010
Relationships (34)

Relation Types:
diso_​to_​anat : 5
diso_​to_​chem : 8
diso_​to_​diso : 20
diso_​to_​phen : 1


Relationships:
none : 27
associated_​with : 1
classifies : 1
is_​associated_​anatomic_​site_​of : 2
is_​finding_​of_​disease : 1
location_​of : 1
mapped_​to : 1
Page Size
Current 25
  Page 1 of 2
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_CHEM91img Antibodies, Monoclonal C0003250
DISO_to_DISO87img chemically induced C0007994
DISO_to_DISO70img Complication Aspects C1171258
DISO_to_DISO53img chemically induced C0007994
DISO_to_DISO43img Complication Aspects C1171258
DISO_to_DISO41img HIV Infections C0019693
DISO_to_CHEM39img Antibodies, Monoclonal C0003250
DISO_to_CHEM39img Immunosuppressive Agents C0021081
DISO_to_DISO36img Acquired Immunodeficiency Syndrome C0001175
DISO_to_ANAT32img Brain C0006104
DISO_to_ANAT30img Brain C0006104
DISO_to_DISO30img Multiple Sclerosis C0026769
DISO_to_DISO27img AIDS Associated Opportunistic Infection C0162526
DISO_to_DISO25img HIV Infections C0019693
DISO_to_DISO24img AIDS Associated Opportunistic Infection C0162526
DISO_to_CHEM23img Antibodies, Humanized C2985546
DISO_to_CHEM23img Immunologic Factors C0021054
DISO_to_DISO20img Immune Reconstitution Inflammatory Syndrome C1619738
DISO_to_DISO20img MS RELAPSING REMITTING C0751967
DISO_to_PHEN19img genetic aspects C0017399
DISO_to_CHEM16img 2(1H)-Pyrimidinone, 4-amino- C0010843
DISO_to_DISO14img Disease due to Polyomaviridae C0949804
DISO_to_DISO14img Lupus Erythematosus, Systemic C0024141
DISO_to_CHEM13img Antiviral Agents C0003451
DISO_to_CHEM12img Antiviral Agents C0003451
Genes (2)

Species:
human : 2
SpeciesGeneGeneIdGene NameEvidence
HumanCCR2729230chemokine (C-C motif) receptor 2
img GENERIF, Score=1000, Pubmed Id: 17560067, UMLKSK CUI: C0023524
HumanCCR51234chemokine (C-C motif) receptor 5 (gene/pseudogene)
img GENERIF, Score=1000, Pubmed Id: 17560067, UMLKSK CUI: C0023524
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0023524Leukoencephalopathy, Progressive Multifocal0self