human : 78
mouse : 1
Truncated forms of the NOTCH1 transmembrane receptor engineered to resemble mutant forms of NOTCH1 found in certain cases of human T cell leukemia/lymphoma (T-ALL) efficiently induce T-ALL when expressed in the bone marrow of mice.
|Human||PRDM16||63976||PR domain containing 16|
Aberrant gene expression associated with DNA hypomethylation is implicated in leukemogenesis of adult T-cell leukemia
ASY/Nogo gene may act as a suppressor against adult T-cell leukemia/lymphoma progression, independent of Tax expression
|Human||FOXP3||50943||forkhead box P3|
We analysed the expression of forkhead/winged helix transcription factor (FoxP3), a specific marker that is important for the function of Treg, on ATLL cells from 17 patients (peripheral blood, n = 8; lymph node, n = 9).
In primary ATLL cells, the expression levels of the Treg cell marker molecules Foxp3 and glucocorticoid-induced tumor necrosis factor receptor family related protein (GITR) were significantly higher than in those from healthy adults.
Expression of FoxP3, a key molecule in CD4CD25 regulatory T cells, in adult T-cell leukaemia/lymphoma cells.
Real-time polymerase chain reaction and immunostaining detected FoxP3 expression in 10 ATLL cases, but was relatively down-regulated compared with Treg from normal subjects.
FOXP3 expression in adult T-cell leukemia/lymphoma and reflects morphological features and is clinically and pathologically associated with an immunosuppressive state
In addition, we also found a high expression of FoxP3 mRNA and protein, a hallmark of regulatory T cells, in ATLL cells, indicating the possibility that ATLL cells originated from regulatory T cells.
|Human||TLX3||30012||T-cell leukemia homeobox 3|
The Significance of HOX11L2/TLX3 expression in children with T-cell acute lymphoblastic leukemia treated on Children's Cancer Group protocols
In T-cell acute lymphoblastic leukemia, alternative t(5;14)(q35;q32.2) forms effect dysregulation of either TLX3 or NKX2-5 homeobox genes at 5q35 by juxtaposition with 14q32.2 breakpoints dispersed across the BCL11B downstream genomic desert
Translocations in Hox11L2 locus is associated with T-cell acute lymphoblastic leukemia
|Human||IKZF2||22807||IKAROS family zinc finger 2 (Helios)|
By Southern blotting, we detected a small deletion in the Helios gene locus of adult T-cell leukaemia/lymphoma patients.
In the present study, we found over-expression of short isoforms of Helios in human T lymphotropic virus-I (HTLV1)-infected patients who had developed chronic and acute forms of adult T-cell leukaemia/lymphoma.
Over-expression of short isoforms of Helios in patients with adult T-cell leukaemia/lymphoma.
|Human||MALT1||10892||mucosa associated lymphoid tissue lymphoma translocation gene 1|
The disease entities are primarily exemplified by mantle cell lymphoma (the relative incidence, 3%, related with an aberrant expression of cyclin D1 activated by t(11;14) chromosomal translocation), follicular lymphoma (7%, with BCL2 by t(14;18) translocation), marginal zone B-cell lymphoma of MALT type (8%, with MALT1 by t(11;18) or t(14;18) translocation), adult T-cell leukemia/lymphoma (7%, but 20% in Kyushu, with human T-cell leukemia virus type 1 [HTLV1]), extranodal NK/T-cell lymphoma of nasal type (2%, with Epstein-Barr virus [EBV]), and anaplastic large cell lymphoma (2%, with ALK by t(2;5) translocation).
|Human||PIAS3||10401||protein inhibitor of activated STAT, 3|
Up-regulation of protein inhibitor of activated STAT3 protein is associated with adult T-cell leukemia
Upregulation of genes due to viral integration was found in two out of nine ATLL cases; about 4.4- and 102-fold elevated ankyrin-1 ( ANK-1) and gephyrin ( GPHN) gene expressions were observed, respectively.
|Human||EBI3||10148||Epstein-Barr virus induced 3|
We show here that EBI3 expression is up-regulated in human T-cell leukemia virus type 1 (HTLV-1)-infected cell lines and IL-2-dependent leukemic cells from adult T-cell leukemia/lymphoma (ATL) patients, compared to normal activated T cells.
|Human||MVP||9961||major vault protein|
LRP was highly expressed and is associated with adult T-cell leukemia/lymphoma
Data suggest that the constitutive expression of IL-32 mRNA as well as the predominant production of a smaller sized IL-32 isoform in Jurkat cells may implicate a role for IL-32 in human T cell leukemia
|Human||IL1RL1||9173||interleukin 1 receptor-like 1|
ST2 was expressed on large transformed lymphoma cells with ATLL, but not in any MF cases.
These findings suggest that CLA and ST2 could be potentially useful immunohistochemical markers for discrimination of mycosis fungoides and cutaneous lesions of ATLL.
|Human||EBAG9||9166||estrogen receptor binding site associated, antigen, 9|
In the present study, an immunohistochemical analysis of RCAS1 expression was performed with lymph node specimens obtained from patients with adult T-cell leukemia/lymphoma (ATLL).
Determination of RCAS1 expression may be useful for predicting the prognosis of patients with ATLL.
Expression of human tumor-associated antigen RCAS1 in adult T-cell leukemia/lymphoma.
|Human||TNFRSF6B||8771||tumor necrosis factor receptor superfamily, member 6b, decoy|
ATLL also showed DcR3 expression and amplification.
To examine the involvement of DcR3 in the immune evasions of virus-associated lymphoma, we analyzed the amplification and expression of DcR3, using dot blot and in situ hybridization (ISH), in 45 cases, which included 17 cases with Epstein-Barr virus (EBV)-associated lymphoma (seven pyothorax-associated B-cell lymphomas (PAL); ten natural killer lymphoma (NKL)), seven cases with adult T-cell leukemia lymphoma (ATLL), 13 Hodgkin;s disease (eight EBV-associated cases; five non-EBV-associated cases), and eight control cases (three reactive lymphadenopathy; five non-EBV-associated-B-cell lymphoma).
|Human||TNFSF10||8743||tumor necrosis factor (ligand) superfamily, member 10|
Cutaneous T-cell lymphoma (CTCL) cell lines revealed pronounced resistance to death ligands (TRAIL and TNF-alpha) as compared to cell lines of T-cell acute lymphoblastic leukemia (T-ALL)
|Human||SOCS1||8651||suppressor of cytokine signaling 1|
Up-regulation of suppressor of cytokine signaling 1 is associated with adult T-cell leukemia
|Human||KDM5D||8284||lysine (K)-specific demethylase 5D|
|Human||TP53||7157||tumor protein p53|
Title:Nonhereditary p53 mutations in T-cell acute lymphoblastic leukemia are associated with the relapse phase.|Association:Not Found|Conclusion:Not Found
|Human||TNFRSF1B||7133||tumor necrosis factor receptor superfamily, member 1B|
We studied tumor necrosis factor (TNF), lymphotoxin-alpha (LT-alpha), and TNF receptors type 1 (TNFR-1) and type 2 (TNFR-2) gene polymorphisms as well as HLA class II DRB1 alleles in Japanese patients with human T-cell lymphotropic virus type I (HTLV-I) associated myelopathy (HAM) (n = 51), patients with adult T-cell leukemia/lymphoma (ATL) (n = 48), asymptomatic HTLV-I carriers (n = 50), and HTLV-I seronegative, normal controls (n = 112).
|Human||TNF||7124||tumor necrosis factor|
Title:Tumor necrosis factor alpha polymorphism associated with increased susceptibility to development of adult T-cell leukemia/lymphoma in human T-lymphotropic virus type 1 carriers.|Association:Y|Conclusion:Genetic polymorphism leading to increased TNF-alpha production may enhance susceptibility to ATL among HTLV-1 carriers. Alternatively, but less likely, the HLA loci might be an important factor because the TNF-alpha gene lies within the class III region of the MHC; however, the 857T allele is not in linkage disequilibrium with HLA alleles associated with ATL development.
|Human||TGFB1||7040||transforming growth factor, beta 1|
Down-regulation of TCF8 expression in ATLL cells was associated with resistance to TGF-beta1, a well-known characteristic of ATLL cells, suggesting that escape from TGF-beta1-mediated growth inhibition is important in the pathogenesis of ATLL
|Human||TFRC||7037||transferrin receptor (p90, CD71)|
Differential expressions of CD25 or CD71 on CD4+ and/or CD8+ tumor cells from a patient with adult T-cell leukemia/lymphoma: three color flowcytometric analysis of peripheral blood and lymph node.
|Human||TERF2||7014||telomeric repeat binding factor 2|
Expression of TIN2, a gene regulator is increased in TIN2 expression in adult T-cell leukemia
|Human||TERF1||7013||telomeric repeat binding factor (NIMA-interacting) 1|
An increase in TIN2 expression in adult T-cell leukemia which may be a markerse for disease progression